Back to School Savings: Save up to 30% on print books and eBooks. No promo code needed.
Back to School Savings: Save up to 30%
Cannabis and the Developing Brain
1st Edition - August 18, 2022
Editors: Miriam Melis, Olivier J Manzoni
Paperback ISBN:9780128234907
9 7 8 - 0 - 1 2 - 8 2 3 4 9 0 - 7
eBook ISBN:9780128236413
9 7 8 - 0 - 1 2 - 8 2 3 6 4 1 - 3
Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and… Read more
Purchase Options
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior.
Cannabis and the Developing Brain
aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors.
Reviews exposure effects on different areas and circuits of the brain
Identifies effects of exposure at prenatal, perinatal, infant, and adolescent ages
Includes cannabis interaction with known genetic and environmental risk factors
Contains neurodevelopment and neuropsychiatric disorders associated with cannabis exposure
Cover
Title page
Table of Contents
Copyright
In memoriam
Contributors
Preface
Chapter 1: Pre-clinical models of neurodevelopmental cannabinoid exposure
Abstract
Introduction
Model considerations
Timing of drug administration
Route of drug administration
Nature of drug administered
Dose of drug administered
Summary
References
Chapter 2: Epigenetic imprint: An underlying link to developmental effects of prenatal cannabis exposure
Abstract
Introduction
Molecular reprogramming after prenatal cannabinoid exposure
Prenatal cannabis exposure and epigenetic mechanisms
Conclusion
References
Chapter 3: Impact of adolescent THC exposure on later adulthood: Focus on mesocorticolimbic function and behaviors
Abstract
Introduction
Cannabis-based products and devices
Cannabinoids, endocannabinoid signaling, and brain development
Evidence from human studies
Evidence from rodent studies
CBD interactions with THC during adolescence
Conclusion
References
Chapter 4: Endocannabinoids and sex differences in the developing social behavior network
Abstracts
Introduction
The social behavior network orchestrates expression of innate social behaviors
Sexual differentiation of the developing brain
Endocannabinoids in developing brain
Adolescent playfulness is a foundational behavior for adult sociality
The extended amygdala is a key node of the social behavior network
Endocannabinoids developmentally program playfulness
Endocannabinoids regulate microglia phagocytic activity in the developing amygdala
The medial preoptic area is also a key node in the social behavior network
Conclusions and open questions
References
Chapter 5: Behavioral consequences of pre/peri-natal Cannabis exposure
Abstract
Acknowledgment
Introduction
Clinical studies on the behavioral consequences of maternal Cannabis exposure
Rodent studies on the behavioral consequences of maternal cannabinoid exposure
Future perspectives
Conclusions
References
Chapter 6: Correlates and consequences of cannabinoid exposure on adolescent brain remodeling: Focus on glial cells and epigenetics
Abstract
Introduction
Glial cells
Epigenetics
References
Chapter 7: Effects of prenatal THC exposure on the mesolimbic dopamine system: Unveiling an endophenotype of sensory information processing deficits
Abstract
Introduction
Pre-natal cannabis exposure as an environmental risk factor for neuropsychiatric disorders
Pre-natal cannabis exposure impacts on the offspring mesolimbic dopamine system
Sex differences in the effects of pre-natal cannabis exposure on mesolimbic dopamine system function
Measuring vulnerability to mental illness induced by pre-natal cannabis exposure: A path toward an early clinical staging
Concluding remarks
References
Chapter 8: Perinatal cannabis exposure and long-term consequences on synaptic programming
Abstract
Acknowledgments
Parental germline cannabis exposure could affect progeny through transgenerational epigenetic alterations
Cannabinoids exposure and peri-embryo implantation influences
Perinatal cannabis exposure and long-term consequences on synaptic programming
Conclusions
References
Chapter 9: Molecular and cellular principles of endocannabinoid signaling and their sensitivity to cannabis in the developing brain
Abstract
Introduction
Cannabis use during pregnancy
The endocannabinoid system
Pre-natal endocannabinoid signaling and the adverse developmental outcomes of its disruption
Post-natal endocannabinoid signaling and adolescent circuit disruption
Conclusion
References
Chapter 10: How adolescent cannabinoid exposure sets the stage for long-term emotional and cognitive dysregulation: Impacts on molecular and neuronal risk pathways
Abstract
Introduction
How cannabinoids control emotional processing: Convergent impacts on mesocorticolimbic dopamine states
Cannabinoid transmission in pre-frontal cortex regulates emotional processing through control of sub-cortical dopamine
Translational rodent models of adolescent cannabinoid exposure
Effects of neurodevelopmental cannabinoid exposure on emotional processing circuits: Addiction implications
Adolescent cannabinoid exposure alters dopaminergic, glutamatergic and GABAergic signaling and associated molecular pathways: Implication for schizophrenia vulnerability
Effects of adolescent cannabinoid exposure on long-term mesolimbic dopamine activity states
Effects of adolescent cannabinoid exposure on pre-frontal cortical regulation of sub-cortical dopamine activity: Impacts on molecular biomarkers for schizophrenia and other neuropsychiatric disorders
Effects of adolescent cannabinoid exposure on pre-frontal cortical GABAergic and glutamatergic functional balance: Implications for the pathophysiology of schizophrenia
Conclusions and future directions
References
Chapter 11: Molecular mechanisms underlying cannabis-induced risk of psychosis
Abstract
Introduction
Schizophrenia
Conclusions
References
Chapter 12: Synthetic cannabinoids: State-of-the-art with a focus on fertility and development
Abstract
The emergence of synthetic cannabinoids
Chemical structure and nomenclature
Epidemiology, patterns of use, and legal status
Pharmacology
Clinical aspects
Synthetic cannabinoids and fertility
References
Chapter 13: Prenatal THC exposure interferes with the neurodevelopmental role of endocannabinoid signaling
Abstract
Introduction
The ECB system in neurogenic niches
Role of ECB signaling in pyramidal neuron development
Role of the ECB system in GABAergic interneuron development
Long-lasting consequences of prenatal THC exposure
Contribution of prenatal ECB signaling alterations to neurodevelopmental disorders
Prenatal cannabinoid exposure in human-based models
Conclusions
References
Chapter 14: Cannabis effects on the adolescent brain
Abstract
Introduction
Adolescence is a critical period of brain development
Endogenous cannabinoid (eCB) system in the adolescent brain
Cannabis and the adolescent brain
Genetic vulnerability to cannabis
Conclusion and future directions
References
Index
No. of pages: 360
Language: English
Published: August 18, 2022
Imprint: Academic Press
Paperback ISBN: 9780128234907
eBook ISBN: 9780128236413
MM
Miriam Melis
Miriam Melis is an Associate Professor at the University of Cagliari, Italy. She holds a PharmD (University of Palermo, 1993) as well as a PhD in Neuroscience (University of Cagliari, 2011). During her career she worked as a Research Fellow for two years at the Ernest Gallo Clinic and Research Center at UCSF and as a Visiting Scientist at Lund Universitet Wallenberg Neuroscience Center in 2011. Her research is focused on understanding neurobiological mechanisms (i.e., adaptations of both mesocorticolimbic dopamine and endocannabinoid signaling) of resilience and susceptibility to adverse neurodevelopmental outcomes leading to neuropsychiatric disorders (e.g., psychotic- spectrum, substance use disorder, antisocial behavior, anxiety, depression). She has published 46 research papers, 5 book chapters and edited two books specifically on the effects of (endo)cannabinoids in the CNS.
Affiliations and expertise
Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy
OM
Olivier J Manzoni
Olivier Manzoni is a Research Director at INSERM in Marseille and director of the International Associated Laboratory CannaLab (University of Indiana, Bloomington USA / Aix-Marseille University, France). His research is centered on understanding the molecular basis of synaptic plasticity in normal and pathological conditions, with a focus on the function of the endocannabinoid system and the effects of cannabis during lifetime.
Affiliations and expertise
Research Director at INSERM in Marseille, Director of the International Associated Laboratory CannaLab (University of Indiana, Bloomington USA / Aix-Marseille University), France