Cannabis and its Derivatives
Guide to Medical Application and Regulatory Challenges
- 1st Edition - May 24, 2024
- Imprint: Academic Press
- Editors: Rahul Shukla, Mayank Handa, Dhirendra Pratap Singh, Ashish Dhir
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 4 8 9 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 4 9 0 - 4
Cannabis and its Derivatives: Guide to Medical Application and Regulatory Challenges summarizes the current state of research and clinical pharmacology of cannabis-based therap… Read more
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Request a sales quoteCannabis and its Derivatives: Guide to Medical Application and Regulatory Challenges summarizes the current state of research and clinical pharmacology of cannabis-based therapeutics, along with associated regulatory frameworks. Sections cover historical, botanical, and taxonomical platforms of cannabis, chemical derivatives of the cannabis plant, a literature review of therapeutic applications, the biological fate of cannabis and its metabolic products, pain management, neurological disorders, cancer management, interactions with other drugs, veterinary applications, and the adverse effects of Cannabis overuse in humans.
The book's final section is devoted to discussions around regulatory challenges and future considerations. This is the ideal reference pharmaceutical scientists, clinicians, and academic researchers who want access to updated information on the therapeutic applications of cannabis and its derivates. Corporate researchers will also benefit from this book’s presentation of the associated regulatory environment.
The book's final section is devoted to discussions around regulatory challenges and future considerations. This is the ideal reference pharmaceutical scientists, clinicians, and academic researchers who want access to updated information on the therapeutic applications of cannabis and its derivates. Corporate researchers will also benefit from this book’s presentation of the associated regulatory environment.
- Explores the potential of Cannabis derivatives and medicinal properties in several medical fields
- Highlights the regulatory challenges around the clinical use and research of Cannabis
- Covers applications to conditions like cancer, neurological disorders, pain management, and interactions with other drugs
Researchers and scientists in Pharmacology, and clinical researchers, Drug development corporate researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Section 1. Introduction
- Chapter 1. Exploring the historical, botanical, and taxonomical foundations of cannabis: A review
- 1. Introduction
- 2. Traditional application of Cannabis sativa L.
- 3. History of cannabis
- 4. Taxonomy
- 5. Botany
- 6. Variation in the genetics of the cannabis genus
- 7. Results and discussion
- 8. Conclusion
- 9. Future perspectives
- Chapter 2. Cannabis and its derivatives: Guide to medical application and regulatory challenges
- 1. Introduction
- 2. Chemistry and constituents of cannabis
- 3. Medicinal use of cannabis: History and current status
- 4. Cannabis legalization, regulation, and control
- Chapter 3. Therapeutic application of cannabis and its derivatives: A detailed literature review about mechanisms of action
- 1. Introduction
- 2. Endocannabinoid system
- 3. Recent status in clinical application
- 4. Cannabis in the treatment of diseases and the mechanistic pathway in treatment
- 5. Conclusion
- Chapter 4. Biological fate of cannabis and its metabolic products
- 1. Introduction
- 2. Metabolites and their biochemistry
- 3. Prevalence of cannabis
- 4. Pharmacokinetics and pharmacodynamics
- 5. Effect of cannabis on neurophysiology
- 6. Effect of cannabis on the cardiovascular system
- 7. Effect of cannabis on the renal system
- 8. Effect of cannabis on respiratory system
- 9. Effect of cannabis on the hepatic system
- 10. Cannabis in the treatment of brain cancer
- 11. Addiction to cannabis
- 12. Conclusion
- List of abbreviations
- Section 2. Therapeutic potential
- Chapter 5. Emerging therapeutic role of cannabis in neurological disorders
- 1. Introduction
- 2. Cannabis and cannabinoids
- 3. Role of cannabinoids in neurological disorders
- 4. Conclusion and future perspectives
- List of abbreviations
- Chapter 6. The potential of cannabis in pain management
- 1. Introduction
- 2. Current approaches for pain management
- 3. Pain and its receptors
- 4. Cannabis and its derivatives as therapeutic in pain
- 5. Preclinical and clinical evidence for cannabis-based therapeutics in pain management
- 6. Current trends of cannabis-based pain management
- 7. Conclusion and future perspectives
- Chapter 7. Cannabis as abused and banned drug
- 1. Introduction
- 2. Cannabis use: patterns (acute and chronic)
- 3. Endocannabinoid systems (ECS)
- 4. Effects of cannabis
- 5. Cannabis and its legislation
- 6. Cannabis and its medicinal applications
- 7. Conclusion
- Chapter 8. Application of cannabis in cancer management therapy
- 1. Introduction
- 2. Plant- and synthetic-based cannabis moieties for cancer mitigation
- 3. Molecular mechanism for cannabis in cancer therapy
- 4. Preclinical and clinical relevance of cannabis-based moieties in cancer management
- 5. Preclinical aspects of cannabis using an in vitro model
- 6. Regulatory consideration for cannabis for cancer therapy (with special emphasis on FDA and EMA)
- 7. Conclusion
- Chapter 9. Interaction of cannabis with other drugs
- 1. Introduction
- 2. Generalized therapeutics for cannabis with other drugs
- 3. Pharmacokinetic interaction of cannabis with other drugs
- 4. Pharmacodynamic interaction of cannabis
- 5. Conclusion
- Section 3. Regulatory aspects
- Chapter 10. Exploring the untapped potential of cannabis in veterinary pharmacology, medicine, and beyond
- 1. Introduction
- 2. Classification of cannabis
- 3. Phytoconstituents of cannabis
- 4. Biosynthesis of phytoconstituents
- 5. Endocannabinoid system
- 6. Pharmacological and medicinal perspective of cannabinoids in the veterinary sector
- 7. Toxicity of cannabis in the veterinary field
- 8. Conclusion
- Chapter 11. Regulatory challenges on cannabis: Concern, advantages, and disadvantages
- 1. Introduction
- 2. Source of cannabis
- 3. Cannabis and its derived products
- 4. Regulatory authorities for cannabis in different countries
- 5. Hemp-federal law and legal status of marijuana or cannabidiol in the USA
- 6. Cannabis and FDA
- 7. Regulations of cannabis in India, Canada, and Japan
- 8. Regulatory laws of EMA for cannabis
- 9. Legal framework for cannabis production for food and medical uses
- 10. Current challenges for cannabis prescription
- 11. Stringent guidelines
- 12. Educating utility and awareness
- 13. Supply chain and cost
- 14. Dependence issues and psychosis
- 15. Ethical challenges
- 16. Pharmacological benefits, adverse effects, and monitoring of patient's prescription
- 17. Risk/benefit ratio balance
- 18. Future perspectives and conclusion
- List of abbreviations
- Chapter 12. Clinical application and future consideration and potential of cannabis
- 1. Introduction
- 2. Therapeutic effects of herbal cannabis: Risks and efficacy
- 3. Cannabis and public health issues
- 4. Evaluation of cannabis benefits
- 5. Regulations, laws, and professional issues
- 6. Future considerations: Lowering the roadblocks to cannabis research
- 7. Large-scale clinical trials
- 8. Cannabis in pain research
- 9. Conclusion and future perspectives
- Index
- Edition: 1
- Published: May 24, 2024
- Imprint: Academic Press
- No. of pages: 400
- Language: English
- Paperback ISBN: 9780443154898
- eBook ISBN: 9780443154904
RS
Rahul Shukla
Dr. Rahul Shukla is currently working as an Assistant Professor (Contract) at Department of Pharmaceutics, NIPER Raebareli, India, He has a PhD in Pharmaceutical Sciences from CSIR CDRI and J.N.U New Delhi, India, an M.Pharm from IIT BHU,Varanasi, India and B.Pharm from Jamia Hamdard, New Delhi. He has more than ten years of research and academic experience with more than 30 publications and 10 book chapters to his credit. He has filed 7 Indian Patent and 1 Copyright. Recently he has edited a book on the Role of Novel Drug Delivery Vehicles in Nanobiomedicine. His current research interests include targeted drug delivery systems, particle engineering, controlled delivery for neurodegenerative diseases, dendrimer mediated drug delivery, solubilization and bioavailability enhancements.
Affiliations and expertise
Assistant Professor, Department of Pharmeceutics, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, IndiaMH
Mayank Handa
Mr. Mayank Handa, has completed his B. Pharm and M. Pharm from U.I.P.S, Panjab University, Chandigarh India. Currently, pursuing as Ph.D. at National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow UP. His past industrial experience includes working at Eisai India Limited, India and Themis Medicare Limited, India. He has more than 20 peer reviewed publications in journals international repute and 10 book chapter. He has filed 5 Indian patent and 1 Copyright. His research interests in polymeric nanoparticles and emulsion based drug delivery, targeted drug delivery systems, Intranasal and transdermal drug delivery.
Affiliations and expertise
National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, IndiaDS
Dhirendra Pratap Singh
Dhirendra Pratap Singh is a trained pharmacologist, having special interest in behavioral neuropharmacology and gut microbial ecology for advanced understanding on gut-microbial-brain axis. He received his Ph.D. in Pharmaceutical Sciences from Panjab University, Chandigarh. He is currently working as Scientist ‘C’ in Neurotoxicology and Immunotoxicology laboratory at ICMR-National Institute of Occupational Health, Ahmedabad. Utilizing his expertise and skill in the interdisciplinary domains of chemical and life sciences he is leading a small independent research group. Two major domains of his research are, translational research for rapid and affordable diagnostics development for environmental toxicants exposure identifications, and basic research on studies exploring the gut microbial modulation strategies for improved brain functions. He has 25 research publication and 3 book chapters in the area of nutrition & metabolism, applied microbiology, neuropharmacology and currently in biomedical microdevices developments.
Affiliations and expertise
Neurotoxicology and Immunotoxicology Laboratory, ICMR-National Institute of Occupational Health, Ahmedabad, IndiaAD
Ashish Dhir
Dr. Ashish Dhir is an Associate Principal Scientist in Drug Discovery for Merck in New Jersey. He was previously a Senior Scientist in the Department of Neurology, School of Medicine, University of California, Davis in Sacramento. He received his doctorate in Pharmacology from Panjab University, Chandigarh, India. He has over 15 years of experience in preclinical research in the field of neurological and neuropsychiatric disorders. Dr. Dhir's research entails establishing and validating animal models of various disease conditions, as well as investigating novel drugs and targets for disease treatment. Dr. Dhir has over 90 peer-reviewed journal papers and serves as an ad hoc reviewer and on the Editorial Board of several prestigious journals. He was recently named to the list of the world's top 2% pharmacology scientists (ranking 1053 out of 94611). Dr. Dhir has received numerous honors, including the Rafaelsen Young Investigator Award from the Collegium International Neuropsychopharmacologicum (CINP).
Affiliations and expertise
Associate Principal Scientist- Drug Discovery, USARead Cannabis and its Derivatives on ScienceDirect