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Cancer Therapy
Potential Applications of Nanotechnology
- 1st Edition - May 24, 2024
- Authors: Surendra Nimesh, Nidhi Gupta, Guilherme Carneiro
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 4 0 1 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 4 0 2 - 7
Cancer Therapy: Potential Applications of Nanotechnology provides readers with a compendium of all the latest research work in cancer therapeutics, including an emphasis on work i… Read more
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Request a sales quoteCancer Therapy: Potential Applications of Nanotechnology provides readers with a compendium of all the latest research work in cancer therapeutics, including an emphasis on work in nanotechnology and polymeric nanoparticles. While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology, especially those with an emphasis on polymeric nanoparticles in cancer therapy. This title enlightens researchers and students and provides exhaustive knowledge on the topics covered.
- Provides a complete overview of the application of different polymeric nanoparticles in cancer therapeutics: from characterization of nanoparticles to in vitro and in vivo studies.
- Contains a detailed description of the delivery of therapeutic molecules with different polymers realized with nanomedicine in cancer therapeutics.
- Discusses newly developed promising polymers in cancer.
- Describes polymeric nanoparticle and their role in theranostics pertaining to cancer.
- Reviews clinical relevance of different polymeric formulations in the field of cancer
Researchers working in the field of nano-cancer therapeutics, Students and researchers working in nucleic acids delivery for gene therapy
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- About the authors
- Foreword
- Preface
- 1. Introduction and barriers in cancer therapeutics
- Abstract
- 1.1 Introduction
- 1.2 Types of cancer
- 1.3 Mechanism of cancer occurrence
- 1.4 Treatment options available for cancer
- 1.5 Limitations of present cancer treatment options
- 1.6 Barriers encountered in cancer therapeutics
- 1.7 Nanotechnology as an option for cancer therapeutics
- References
- 2. Nanoencapsulation approaches for enhancing cancer therapy
- Abstract
- 2.1 Introduction
- 2.2 Potentiality for the nanoencapsulation of anticancer agents
- 2.3 Nanostructured drug delivery systems
- 2.4 Nanotechnology application in cancer therapy
- 2.5 Current challenges of nanostructured drug delivery systems designing
- 2.6 Novel applications of nanotechnology in cancer
- 2.7 Conclusion
- References
- 3. Polymeric nanomaterial: expanding horizons in cancer therapeutics
- Abstract
- 3.1 Introduction
- 3.2 Synthesis of polymeric nanoparticles
- 3.3 Classification of polymeric nanoparticles
- 3.4 Biomedical application of polymeric nanoparticles in cancer therapy
- References
- 4. Chitosan nanoparticles for gene delivery in cancer therapy and disease diagnosis
- Abstract
- 4.1 Introduction
- 4.2 Chitosan nanoparticles
- 4.3 Therapeutic oligonucleotides delivered via chitosan nanoparticles in cancer therapy
- 4.4 Chitosan nanoparticles in cancer diagnosis
- 4.5 Patents in cancer gene delivery via chitosan nanoparticles
- 4.6 Conclusion
- References
- 5. Polyethylenimine: an efficient carrier in cancer therapeutics
- Abstract
- 5.1 Introduction
- 5.2 Basics of PEI
- 5.3 Modification of PEI
- 5.4 PEI-based chemotherapy
- 5.5 PEI as drug delivery system in cancer
- 5.6 PEI-based gene therapy
- 5.7 Other PEI-based cancer therapies
- 5.8 Conclusion
- References
- 6. Poly(L-glutamic) acid: a potential polymer in cancer therapy
- Abstract
- 6.1 Introduction
- 6.2 Synthesis of γ-PGA
- 6.3 Biomedical applications of γ-polyglutamic acid
- 6.4 Application of PGA in cancer therapy
- References
- 7. Poly lactic-co-glycolic acid nanoparticles for anticancer therapy
- Abstract
- 7.1 Introduction
- 7.2 Chemical nature, synthesis, and characterization of poly lactic-co-glycolic acid
- 7.3 Advantages of poly lactic-co-glycolic acid as a nanoparticle for drug delivery
- 7.4 Anticancer properties of poly lactic-co-glycolic acid nanoparticles
- 7.5 Anticancer drugs delivered using poly lactic-co-glycolic acid nanoparticles
- 7.6 Mechanism(s) of the release of drugs from poly lactic-co-glycolic acid nanoparticles
- 7.7 Poly lactic-co-glycolic acid along with other nanoparticles as anticancer agent
- 7.8 Toxicity associated with poly lactic-co-glycolic acid
- 7.9 Conclusion
- Future directions
- References
- 8. Dendrimers as anticancer delivery vectors
- Abstract
- 8.1 Introduction
- 8.2 Synthesis of dendrimers
- 8.3 Classification of dendrimers
- 8.4 Biomedical applications of dendrimers
- 8.5 Antimicrobial agent
- 8.6 Tissue engineering
- 8.7 Transfection
- 8.8 Drug delivery
- 8.9 Dendrimers for cancer therapy
- References
- 9. Poly(lactic acid) (PLA) as drug and gene delivery system for tumor
- Abstract
- 9.1 Introduction
- 9.2 The importance of regulated drugs and gene delivery methods
- 9.3 Overview of PLA as a biodegradable and biocompatible polymer
- 9.4 Synthesis of poly(lactic acid)
- 9.5 Influence of monomer ratio on poly(lactic acid) properties
- 9.6 Techniques for modifying poly(lactic acid) characteristics
- 9.7 Applications of poly(lactic acid) for drug delivery
- 9.8 Targeted delivery of chemotherapeutic agents using poly(lactic acid) nanoparticles
- 9.9 Combination drug delivery for cancer with poly(lactic acid)-based systems
- 9.10 Poly(lactic acid) based nanoparticles for drug delivery
- 9.11 Poly(lactic acid) nanocomposites
- 9.12 Poly(lactic acid) microparticles
- 9.13 Poly(lactic acid) microparticles for drug delivery in cancer
- 9.14 Poly(lactic acid)-mediated gene delivery platforms
- 9.15 Plasmid DNA/RNA delivery using poly(lactic acid)-based nanoparticles
- 9.16 microRNA delivery in cancer therapy
- 9.17 siRNA delivery in cancer therapy
- 9.18 shRNA delivery in cancer therapy
- 9.19 Significance of poly(lactic acid) platforms for drug and gene delivery
- 9.20 Challenges and future prospects
- 9.21 Future prospectives
- 9.22 Conclusion
- References
- 10. Poly-L-lysine futuristic amino acid nanoformulations: synthesis and applications
- Abstract
- 10.1 Introduction
- 10.2 Context about poly-L-lysine
- 10.3 Basic processes for synthesizing polymer
- 10.4 Poly-L-arginine
- 10.5 Poly-L-histidine
- 10.6 Applications
- 10.7 Conclusion
- References
- 11. Poly(ε-caprolactone) in anticancer drug delivery: current updates
- Abstract
- 11.1 Introduction
- 11.2 Poly(ε-caprolactone)
- 11.3 Poly(lactide-co-glycolide) vis-à-vis poly(ε-caprolactone)
- 11.4 Synthesis of poly(ε-caprolactone)
- 11.5 Modifications of poly(ε-caprolactone)
- 11.6 Consequences of poly(ε-caprolactone) modifications
- 11.7 The unique crystalline structure of poly(ε-caprolactone): a key attribute
- 11.8 Utilization of poly(ε-caprolactone) for anticancer drug delivery
- 11.9 Future prospects
- Acknowledgment
- References
- 12. Poly(alkyl cyanoacrylate): advancement as nano delivery systems
- Abstract
- 12.1 Introduction
- 12.2 Poly(alkyl cyanoacrylate) as a polymer for nanoformulations
- 12.3 Applications
- 12.4 Conclusion and future prospects
- References
- 13. Polymeric micelles: multifunctional properties and applications in cancer
- Abstract
- 13.1 Introduction
- 13.2 Basic considerations of polymeric micelles
- 13.3 Stability of polymeric micelles
- 13.4 Multifunctional properties of polymeric micelles
- 13.5 Applications of polymeric micelles
- 13.6 Marketed polymeric micelles
- 13.7 Conclusion
- Acknowledgment
- References
- 14. Polymeric nanomaterials in theranostics
- Abstract
- 14.1 Introduction
- 14.2 Polymeric nanomaterials in theranostics
- 14.3 Applications of polymeric nanotheranostics
- 14.4 Conclusion
- Acknowledgment
- References
- 15. Development of promising polymers as vectors in cancer therapy
- Abstract
- 15.1 Introduction
- 15.2 Targeting approaches
- 15.3 Polymer-based nanoparticles as vectors for drug delivery
- 15.4 Development of polymer-based vectors
- 15.5 Polymer-based nanosystems
- 15.6 Polymer hybrid–based systems
- 15.7 Conclusion
- Acknowledgment
- References
- 16. Liposomes and their historical use for cancer applications
- Abstract
- 16.1 Introduction
- 16.2 Liposomes as drug nanocarriers
- 16.3 Liposomes in anticancer therapy
- 16.4 Liposomes containing anticancer drugs: the state-of-art
- 16.5 Conclusions and future perspectives
- References
- 17. Lipid nanoparticles loaded with anticancer bioactives: state of the art
- Abstract
- 17.1 Introduction
- 17.2 Liposomes
- 17.3 Lipid nanoparticles for gene therapy
- 17.4 Solid lipid nanoparticles and nanostructured lipid carriers
- 17.5 Other lipid nanoparticles
- 17.6 Stimuli-responsive lipid nanoparticles
- 17.7 Application in anticancer drug delivery
- 17.8 Landscape of research
- Acknowledgments
- Conflict of interest
- References
- 18. Clinical updates, approaches, and future perspectives
- Abstract
- 18.1 Introduction
- 18.2 Regulation of the clinical trials process
- 18.3 Barriers in the processing of the clinical trials
- 18.4 Overcoming the barriers in the clinical trials
- 18.5 Clinical applications and evaluation of nanotherapeutics against cancer
- 18.6 Conclusion
- References
- Index
- No. of pages: 550
- Language: English
- Edition: 1
- Published: May 24, 2024
- Imprint: Elsevier
- Paperback ISBN: 9780443154010
- eBook ISBN: 9780443154027
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Surendra Nimesh
Dr. Surendra Nimesh did PhD in nanotechnology from Dr. B.R. Ambedkar Center for Biomedical Science Research, University of Delhi and CSIR-Institute of Genomics and Integrative Biology, Delhi, India. He did postdoctorate at Ecole Polytechnique of Montreal, Montreal; Clinical Research Institute of Montreal, Montreal and Health Canada, Ottawa, Canada. He has published several research and review articles and authored/coauthored seven books that includes two Elsevier books: The Design and Development of Novel Drugs and Vaccines (2021) and Gene Therapy: Potential Applications of Nanotechnology (2013). He is an internationally recognized expert of nanotechnology for biological applications with specialization in drug and gene delivery.
Affiliations and expertise
Professor, Department of Biotechnology, Central University of Rajasthan, Ajmer, India; Professor (Adjunct), Department of Biomedical Science, Maharaja Surajmal Brij University, Bharatpur, India.NG
Nidhi Gupta
Dr. Nidhi Gupta received PhD degree in virology from the National Institute of Immunology and Jawaharlal Nehru University, New Delhi, India. She did doctoral research at Clinical Research Institute of Montreal, Montreal, and McGill University, Montreal, Canada. She has several research and review articles to her credit along with three authored/coauthored books. Her field of interest includes catalytic nucleic acids, siRNA, antisense, and nanomedicine.
Affiliations and expertise
Professor, Department of Biotechnology, IIS (Deemed to be University), Jaipur, IndiaGC
Guilherme Carneiro
Dr. Guilherme Carneiro did PhD in pharmaceutical sciences from Dr. L.A.M Ferreira in the Federal University of Minas Gerais, Belo Horizonte, Brazil. After completing the doctoral research, he joined the Federal University of the Jequitinhonha and Mucuri Valleys, Brazil, as an assistant professor. His field of research includes lipid nanocarriers, hydrophobic ion pairing, cancer chemotherapy, skin permeation, neglected diseases (e.g., leishmaniasis, Chagas’ disease), cosmetics, and food and packaging application.
Affiliations and expertise
Professor, Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, BrazilRead Cancer Therapy on ScienceDirect