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Camptothecin and Camptothecin Producing Plants
Botany, Chemistry, Anticancer Activity and Biotechnology
- 1st Edition - June 18, 2020
- Authors: T. Pullaiah, P.B. Raghavendra, S. Karuppusamy, V. Raveendran, M. Anuradha
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 4 9 9 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 9 2 7 - 1
Camptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity and Biotechnology provides updated information on camptothecin yielding plants, chemic… Read more
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Request a sales quoteCamptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity and Biotechnology provides updated information on camptothecin yielding plants, chemical diversity of camptothecin, extraction and exploitation methods, biosynthesis, biotechnological production and enhancement for drug delivery, and the pharmacological properties of the drugs. The book focuses on camptothecin anticancer properties based on recent developments of biotechnology. Topics emphasize anticancer activities, biosynthesis, potent derivatives currently undergoing experimental phases, and biotechnological methods to enhance the production. This book is a valuable source for cancer researchers, oncologists, biotechnologists, pharmacologists and members of the biomedical field who are interested in camptothecin and its applicability in cancer treatment.
- Provides information on camptothecin producing plants and their anticancer properties for the development of new treatments
- Discusses new applications of camptothecin based on recent biotechnology advancements
- Presents comprehensive information on the pharmacology of camptothecin for leveraging new anticancer drugs developments
Cancer researchers, bioinformaticians, molecular biologists, medicinal chemists, pharmacists
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Abbreviations
- Chapter 1. Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives
- Abstract
- 1.1 Introduction
- 1.2 The principles underlying transformation of normal cells into tumor
- 1.3 Nuclear transcription factor kappa B
- 1.4 Programmed cell death-apoptosis
- 1.5 Targeted cancer therapy
- 1.6 Molecular mechanisms of drug resistance in cancer
- 1.7 Strategy to overcome chemoresistance
- 1.8 Camptothecin
- 1.9 Conclusions
- References
- Chapter 2. Camptothecin: chemistry, biosynthesis, analogs, and chemical synthesis
- Abstract
- 2.1 Introduction
- 2.2 Chemistry of camptothecin
- 2.3 A historical account on the discovery of camptothecin
- 2.4 Plant sources of camptothecin
- 2.5 Factors affecting camptothecin production in plants
- 2.6 Camptothecin from endophytes
- 2.7 Biosynthetic pathway
- 2.8 Extraction of camptothecin
- 2.9 Clinically useful derivatives of camptothecin
- 2.10 Analogs of camptothecin under clinical investigation
- 2.11 Synthetic studies
- References
- Chapter 3. Camptothecin and analogs: role in anticancer activities
- Abstract
- 3.1 Introduction
- 3.2 Antitumor effects of camptothecin and analogs in breast cancer
- 3.3 Antitumor effects of camptothecin and analogs in leukemia disorders
- 3.4 Antitumor effects of camptothecin and analogs in hepatocellular carcinoma and colorectal cancer
- 3.5 Antitumor effects of camptothecin and analogs in lung cancer
- 3.6 Antitumor effects of camptothecin and analogs in glioblastoma multiforme
- 3.7 Antitumor effects of camptothecin in nasopharyngeal carcinoma
- 3.8 Antitumor effects of camptothecin nanoparticles
- 3.9 Enhancement of antitumor effects of camptothecin by combinational therapies
- 3.10 Conclusions
- References
- Chapter 4. Botany of camptothecin-yielding plants
- Abstract
- 4.1 Introduction
- 4.2 Camptothecin-yielding plants
- References
- Chapter 5. Propagation of camptothecin biosynthesizing plants
- Abstract
- Abbreviations
- 5.1 Introduction
- 5.2 Camptotheca acuminata
- 5.3 Nothapodytes nimmoniana
- 5.4 Chonemorpha fragrans
- 5.5 Ophiorrhiza species
- 5.6 Apodytes dimidiata
- Acknowledgment
- References
- Patents
- Chapter 6. In vitro camptothecin production from plants: prospects and challenges
- Abstract
- 6.1 Introduction
- 6.2 In vitro camptothecin production
- References
- Chapter 7. Biomining of camptothecin producing plants through molecular techniques
- Abstract
- 7.1 Introduction
- 7.2 Enzymes regulating camptothecin biosynthetic pathway and their BLAST search
- 7.3 Comparative sequence data analysis
- 7.4 Identification of candidate gene involved in camptothecin synthesis
- 7.5 Prospecting phylogenetically related species of Nothapodytes nimmoniana for camptothecin production
- 7.6 Phylogenetic relationship of genus Ophiorrhiza and their camptothecin producing ability
- 7.7 Molecular dynamics simulations from camptothecin producing plants on DNA topoisomerses I
- 7.8 Camptothecin production of C. acuminata and their relatives through phylogenetic analysis
- 7.9 Molecular mechanism of camptothecin synthesis in Camptotheca acuminata
- 7.10 Molecular relationship of Dysoxylum gotadhora with alkaloid producing Rubiaceae members
- 7.11 Phylogenetic relationship of CPT-producing Icacinaceae
- References
- Chapter 8. Endophytes and camptothecin production
- Abstract
- 8.1 Introduction
- 8.2 Fungal endophytes
- 8.3 Fungal strains and attenuation of camptothecin production
- 8.4 Bacterial endophytes
- References
- Index
- No. of pages: 376
- Language: English
- Edition: 1
- Published: June 18, 2020
- Imprint: Academic Press
- Paperback ISBN: 9780128204993
- eBook ISBN: 9780128209271
TP
T. Pullaiah
Professor T. Pullaiah is a former Professor at the Department of Botany at Sri Krishnadevaraya University in Andhra Pradesh, India, where he has taught for more than 35 years. He was President of Indian Botanical Society (2014), President of the Indian Association for Angiosperm Taxonomy (2013). He was awarded the Panchanan Maheshwari Gold Medal, the Prof. P.C.Trivedi Medal, the Dr. G. Panigrahi Memorial Lecture award of the Indian Botanical Society and Prof. Y.D. Tyagi Gold Medal of the Indian Association for Angiosperm Taxonomy. Under his guidance 54 students obtained their doctoral degrees. He has authored 52 books, edited 23 books and published over 330 research papers, including reviews and book chapters. He was also a member of Species Survival Commission of the International Union for Conservation of Nature (IUCN). Professor Pullaiah received his PhD from Andhra University, India, attended Moscow State University, Russia, and worked as Post-Doctoral Fellow
Affiliations and expertise
Department of Botany, Sri Krishnadevaraya University, Anantapur, IndiaPR
P.B. Raghavendra
Dr. P.B. Raghavendra is currently affiliated with School of Regenerative Medicine, Manipal University, Bangalore, India, and has served as Director of School of Chemical and Biological Sciences, REVA University. He is the author of Book Advances in Cell and Molecular Diagnostics and a number of articles and book chapters on various aspects of medical sciences and life sciences published in International journals. He is a visiting professor and technology consultant for many universities and biotechnology companies.
Affiliations and expertise
School of Regenerative Medicine, Manipal University, Bangalore, IndiaSK
S. Karuppusamy
Dr. S. Karuppusamy is currently affiliated with the Department of Botany, The Madura college, Madurai, India. He was Post Doctoral Fellow at Sri Krishnadevaraya University. He has published 10 books and 120 research papers. He was awarded Prof. Y.S.Murthy Gold Medal from Indian Botanical Society.
Affiliations and expertise
Department of Botany, The Madura College, Madurai, IndiaVR
V. Raveendran
Dr. V. Raveendran is working as Associate Scientist, Cardiovascular Research Program, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia. He was a Post-Doctoral fellow at Department of Internal Medicine, University of Kansas Medical Center, Kansas, USA.
Affiliations and expertise
Associate Scientist, Department of Cell Biology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi ArabiaMA
M. Anuradha
Dr. M. Anuradha is currently affiliated to Padmashree Institute of Management and Sciences, Bangalore, India. She was scientist at Dr. Reddy’s research foundation, Hyderabad, India and Sami Labs Pvt. Ltd. Bangalore, India. She published one book and more than 30 papers in national and international journals and co- author for book chapters. She also filed 6 Indian patents and has one US patent granted. She successfully completed four research projects on camptothecin yielding plants supported by Department of Science and Technology, New Delhi and National Medicinal Plants Board, New Delhi and consultant to private herbal companies dealing with camptothecin.
Affiliations and expertise
Institute of Management and Sciences, Bangalore, IndiaRead Camptothecin and Camptothecin Producing Plants on ScienceDirect