
Calcium and Cell Function
Volume 3
- 1st Edition - January 28, 1983
- Editor: Wai Yiu Cheung
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 4 0 5 - 5
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 7 4 8 - 2
Calcium and Cell Function, Volume III covers the many aspects of research on calcium, dealing with its biochemistry, biology, and pharmacology in animals as well as in plants. The… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteCalcium and Cell Function, Volume III covers the many aspects of research on calcium, dealing with its biochemistry, biology, and pharmacology in animals as well as in plants. The book discusses a novel cellular signaling system based on the integration of phospholipid and calcium metabolism; the transport of calcium by sarcoplasmic reticulum; and the energetics and chemistry for interactions between calmodulin and calmodulin-binding proteins. The text also describes the specificity of trifluoperazine and related phenothiazines for calcium-binding proteins; the structure, function, and regulation of phosphorylase kinase; and the regulation of glycogen synthase by multiple protein kinases. The role of calmodulin in synaptic function and neurosecretion; the stimulation of the synthesis of neurotransmitters by calmodulin-dependent phosphorylation; as well as the role of calcium in axoplasmic transport in nerve are also considered. The book further tackles calcium control of the intestinal microvillus cytoskeleton; the possible role of calmodulin in the regulation of insulin release and protein phosphorylation by calcium and cyclic AMP; and the role of calcium in mediating cellular functions important for growth and development in higher plants. The text also looks into the localization of calmodulin in tissue culture cells; and the characterization and regulation of calcium-dependent neutral protease. Zoologists, cell biologists, biochemists, and pharmacologists will find the book invaluable.
Contributors
Preface
Contents of Previous Volumes
Chapter 1 A Novel Cellular Signaling System Based on the Integration of Phospholipid and Calcium Metabolism
I. Introduction
II. Agonist-Dependent Phospholipid Metabolism
III. Role of Calcium in Regulating Phospholipid Metabolism
IV. The Role of Agonist-Dependent Phospholipid Metabolism
V. Conclusion
References
Chapter 2 The Transport of Calcium by Sarcoplasmic Reticulum
I. Introduction
II. Structure of Membranes Participating in Excitation-Contraction Coupling
III. Protein Composition of Sarcoplasmic Reticulum
IV. Lipids of Sarcoplasmic Reticulum
V. Mechanism of ATP Hydrolysis and Ca2+ Transport
VI. Protein-Protein Interactions in Sarcoplasmic Reticulum
VII. Permeability of Sarcoplasmic Reticulum
VIII. Relationship between Membrane Potential and Calcium Transport by the Sarcoplasmic Reticulum
IX. Transport of Calcium by Cardiac Sarcoplasmic Reticulum
X. Sarcoplasmic Reticulum in Fast-Twitch and Slow-Twitch Skeletal Muscles
XI. Biosynthesis of Sarcoplasmic Reticulum
XII. Sarcoplasmic Reticulum in Diseased Muscle
References
Chapter 3 The Energetics and Chemistry for Interactions between Calmodulin and Calmodulin-Binding Proteins
I. Chemistry of Calmodulin Interactions with Calmodulin-Binding Proteins
II. Energetics of Calmodulin Binding to Calmodulin-Binding Proteins
References
Chapter 4 Specificity of Trifluoperazine and Related Phenothiazines for Calcium-Binding Proteins
I. Introduction
II. Mode of Binding of Phenothiazines to Calmodulin
III. Selectivity of Calmodulin for Phenothiazines and Related Antipsychotic Agents
IV. Site of Action of Phenothiazines as Calmodulin Antagonists
V. Selectivity of Phenothiazines for Calmodulin
VI. Other Effects of Phenothiazines
VII. Conclusions
References
Chapter 5 Structure, Function, and Regulation of Phosphorylase Kinase
I. Historical Background
II. Purification
III. General Structure
IV. Structure and Function of the Subunits
V. Phosphorylase Kinase from Other Sources
References
Chapter 6 Regulation of Glycogen Synthase by Multiple Protein Kinases
I. Introduction
II. Glycogen Synthase Structure
III. Phosphorylation by Specific Kinases in Vitro
IV. Relationship of Synthase Activity to Phosphorylation State
V. Glycogen Synthase Phosphatase
VI. Hormonal Regulation of Synthase
References
Chapter 7 Actomyosin of Smooth Muscle
I. Introduction
II. Contractile Apparatus
III. Regulation of Contractile Activity
IV. Evidence for and against the Phosphorylation Theory
V. Summary of the Regulatory Process in Smooth Muscle
References
Chapter 8 Calmodulin in Synaptic Function and Neurosecretion
I. Introduction
II. Synaptic Calmodulin
III. Calmodulin and Ca2+-Dependent Neurotransmitter Release
IV. Ca2+-Calmodulin-Stimulated Synaptic Protein Phosphorylation
V. Evidence Suggesting That Synaptic Ca2+ and Calmodulin-Stimulated Protein Phosphorylation Mediates Ca2+-Dependent Neurotransmitter Release
VI. Ca2+-Calmodulin Synaptic Vesicle and Synaptic Membrane Interactions
VII. Ca2+-Calmodulin Tubulin Kinase System in Synaptic Modulation
VIII. A Molecular Approach to Neurotransmission
References
Chapter 9 Stimulation of Synthesis of Neurotransmitters by Calmodulin-Dependent Phosphorylation
I. Introduction
II. Activation of Tryptophan Hydroxylase by a Calmodulin-Dependent Phosphorylation Reaction
III. Possible Role for Calmodulin in the Activation of Tyrosine Hydroxylase by Phosphorylating Conditions
IV. Existence of Ca2+-Calmodulin-Dependent Tryptophan or Tyrosine Hydroxylase Kinase in Brain
V. Summary
References
Chapter 10 The Role of Calcium in Axoplasmic Transport in Nerve
I. Properties of Axoplasmic Transport
II. Dependence of Transport on Ca2+
III. Partial Sustaining Effect of Mg2+ on Transport
IV. Transport of Ca2+
V. Properties of Calcium-Binding Protein
VI. Isolation of Calmodulin from Mammalian Nerve
VII. Calcium and the Mechanism of Fast Axoplasmic Transport
VIII. Regulation of Ca2+ in Nerve
References
Chapter 11 Calcium Control of the Intestinal Microvillus Cytoskeleton
I. Introduction
II. Microvillus Calmodulin
III. Calcium Sensitivity of Microvillus Core Filaments
IV. Villin
V. Other Major Structural Proteins of the Core Filament Bundle
VI. Relationship of the Brush Border Cytoskeleton to the Vitamin D-Regulated Calcium Uptake System
VII. Do Microvilli Move ?
References
Chapter 12 Regulation of Insulin Release and Protein Phosphorylation by Calcium and Cyclic AMP: Possible Role for Calmodulin
I. Introduction
II. Role of Calcium and Cyclic AMP in Insulin Release
III. Protein Phosphorylation in Hamster Insulinoma Cells
IV. Possible Role for Calmodulin in Insulin Release
V. Summary
References
Chapter 13 Role of Calcium in Mediating Cellular Functions Important for Growth and Development in Higher Plants
I. Introduction
II. Calcium Uptake, Transport, and Distribution
III. Cellular Level Functions Mediated by Calcium
IV. Calcium and Plant Tropisms
V. Conclusion
References
Chapter 14 Localization of Calmodulin in Tissue Culture Cells
I. Introduction
II. Calmodulin Antibody: Detection of Occupied Cellular Acceptor Proteins
III. Fluorescent Calmodulin: Detection of Unoccupied Cellular Acceptor Proteins
IV. Calmodulin Acceptor Proteins: Purification and Localization
V. Epilogue
References
Chapter 15 Calcium-Dependent Neutral Protease: Its Characterization and Regulation
I. Introduction
II. Purification and Characterization
III. Role of Calcium Ion
IV. Substrate Specificity
V. Conversion of m-CANP to μ-CANP
VI. Endogenous Inhibitor
VII. Exogenous Inhibitor and Muscle Dystrophy
R eferences
Index
- No. of pages: 526
- Language: English
- Edition: 1
- Published: January 28, 1983
- Imprint: Academic Press
- Paperback ISBN: 9781483204055
- eBook ISBN: 9781483217482
Read Calcium and Cell Function on ScienceDirect