Black Seeds (Nigella sativa)

Pharmacological and Therapeutic Applications

1st Edition - September 23, 2021
Imprint: Elsevier
Editors: Andleeb Khan, Muneeb U Rehman
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 4 6 2 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 2 9 - 5

Black Seeds (Nigella sativa) is a comprehensive resource covering all aspects of this medicinal plant, well-known for its positive effects in many human ailments. It has been used… Read more

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Black Seeds (Nigella sativa) is a comprehensive resource covering all aspects of this medicinal plant, well-known for its positive effects in many human ailments. It has been used to promote health and fight diseases, and has been found to have antioxidant, antihypertensive, anti-diabetic, anti-inflammatory, and analgesic effects. It has also been known to have antimicrobial, anticancer, neuro-protectant, cardio protectant, immunomodulator, hepatic protectant characteristics. Thymoquinone, the active compound of the plant, also exhibits these protective qualities against many disorders. This book summarizes the effect of this plant on all the organ systems of the body. Black Seeds (Nigella sativa) is a comprehensive resource for researchers working in pharmacology, food chemistry and pharmaceutical chemistry, both in industry and academia.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Chapter 1 History and traditional uses of black seeds (Nigella sativa)
Abstract
Introduction
Historical background
Characteristics of Nigella sativa plant
Chemical composition of the black seed
Role of Nigella sativa in traditional Arabic and Islamic Medicine
Role of Nigella sativa in Indian system of medicine
Role of Nigella sativa in traditional Chinese medicine
Role of Nigella sativa in traditional Malay medicine
Pharmacological significance of Nigella sativa in humans
Anti-inflammatory and analgesic properties of Nigella sativa
Antitumorigenic and antimutagenic effects
Hepatoprotective effects
Nephroprotection
Pulmonary protection and immune boosting properties
Antidiabetic and antiobesity properties
Action against gastric ulcers
Cardioprotective effects
Neuropharmacological actions
Reproprotective and contraceptive effects
Antimicrobial and anti-parasitic properties
Conclusion
Future prospective
References
Chapter 2 Nigella sativa: From chemistry to medicine
Abstract
Introduction
Chemistry
High-value bioactive chemicals (phytoconstituents) in Nigella sativa
Essential or volatile oils
Novel lipid constituents and fatty acids
Sterols and saponins
Phenolic compounds
Alkaloids
Other nutritional values
Pharmacological and bioactive potential of Nigella Sativa
Antibacterial activity
Antifungal activity
Antischistosomiasis activity
Antioxidant activity
Metabolic syndrome
Antidiabetic activity
Anticancer activity
Antiinflammatory activity
Wound healing activity
Gastroprotective effect
Immunomodulatory activity
Cardiovascular activity
Contraceptive and antifertility
Antioxytocic activity
Testicular-protective activity
Neuropharmacological activities
Anticonvulsant activity
Hepatoprotective activity
Toxicological updates
Conclusion
References
Chapter 3 Nigella sativa, a cure for every disease: Phytochemistry, biological activities, and clinical trials
Abstract
Introduction
About Nigella sativa L
Pharmacognostical characteristics
Synonyms
Traditional uses of Nigella sativa L
Chemical composition of Nigella sativa L
Bioavailability, safety, and toxicity of Nigella Sativa L
Treatment of male infertility
Memory, attention, cognition, and anxiety treatment
COVID-19 (HNS-COVID-PK)
Effects of black cumin (Nigella sativa) on biological systems
Analgesic effects
Hepatobiliary system
Antitoxicity effects
Nervous system
Reproductive system
Skeletal system
Antioxidant
Antimicrobial
Anticancer
Conclusion
Future perspectives
Reference
Chapter 4 A review of Nigella sativa and its active principles as anticancer agents
Abstract
Introduction
History of Nigella sativa
Bioactive constituents of Nigella sativa
Therapeutic and medicinal utilities of Nigella sativa
Antidiabetic activity
Different approaches of delivery systems for Nigella sativa and bioactive constituents used in anticancer therapy
Anticancer activity of Nigella sativa
Blood cancer
Lung cancer
Breast cancer
Colon cancer
Renal cancer
Hepatic cancer
Prostate cancer
In vivo and in vitro anticancer studies of Nigella sativa
Antimutagenic activities of Nigella sativa
Effects of Nigella sativa on natural killer cytotoxic activity
Conclusions and future perspectives
References
Chapter 5 Dermatological effects of Nigella sativa: A cosmetic and therapeutic approach
Abstract
Introduction
Dermato-cosmeceutical effects of Nigella sativa
Therapeutic applications of Nigella sativa in dermatology
Noninfectious skin disorders
Other uses of Nigella sativa in dermatology
Safety profile of Nigella sativa in dermatology
Nanoformulations of thymoquinone
Conclusions
Acknowledgements
References
Chapter 6 Nigella sativa and its chemical constituents: A promising approach against neurodegenerative disorders
Abstract
Introduction
The detailed structure of Nigella sativa
Chemical composition of Nigella sativa
Miscellaneous role of Nigella sativa
Summary and conclusion
References
Chapter 7 A meta-analysis of Nigella sativa in respiratory disorders
Abstract
Introduction
Composition of Nigella sativa seeds
Antiinflammatory effects of Nigella sativa and its constituents in pulmonary activity
Asthma
Allergic rhinitis
Lung cancer
Nasal dryness
Emphysema
Chronic obstructive pulmonary disease
Evaluation of subjective feeling in patients with allergic diseases
COVID-19
Pneumonia
Future prospective
Conclusion
References
Chapter 8 Nigella sativa and its active principles: Potential food for healthy living
Abstract
Introduction
Active components of Nigella sativa
Role in health benefits
Conclusion
References
Chapter 9 Therapeutic effects of Nigella sativa on hormonal dysfunctions
Abstract
Introduction
Therapeutically active ingredients of Nigella sativa
Nigella sativa therapeutic in thyroid hormone imbalance
Nigella sativa therapeutic potential in diabetes mellitus
Nigella sativa therapeutic potential in sex hormone imbalance
Nigella sativa effect on the adrenal glands
Applications of Nigella sativa on hormone related pharmacology and toxicology
Discussion
Conclusion
References
Chapter 10 The cardioprotective effect of thymoquinone from Nigella sativa
Abstract
Introduction
Role of thymoquinone in cardiovascular diseases
Protective effect of thymoquinone against chemical cardiotoxic agents
Conclusion
References
Chapter 11 Black seeds of Nigella Sativa: A remedy for advanced cancer therapeutics with special reference to nanotechnology
Abstract
Introduction
Source and occurrence
Pharmacognostical characteristics
Chemical composition
Pharmacological properties of Nigella sativa
General therapeutic properties
Toxicological properties and safety evaluation of Nigella sativa
Chemopreventive and anticancer effects
Future perspective and conclusion
Abbreviations
Conflict of interest
Acknowledgement
References
Chapter 12 Nigella sativa as a therapeutic candidate for arthritis and related disorders
Abstract
Introduction
Antioxidant role of Nigella sativa and thymoquinone against arthritis
Nigella sativa as antiinflammatory agent against arthritis
Preclinical studies of Nigella sativa in arthritis
Arthritis animal models and role of Nigella sativa fixed oil or components
Clinical studies on management of arthritis by using Nigella sativa fixed oil
Mechanism of action to attenuate arthritis by Nigella sativa/thymoquinone
Conclusion
Acknowledgements
Conflict of interest statement
Abbreviations
References
Chapter 13 Therapeutic potential of Nigella sativa in the prevention of aggregation and glycation of proteins
Abstract
Introduction
Role of Nigella sativa in the prevention of protein aggregation
Role of Nigella sativa in the prevention of glycation
Advanced glycation end products inhibitors
Relation between protein aggregation and glycation
Conclusion
Acknowledgement
Conflict of interest
Abbreviations
References
Chapter 14 Role of Nigella sativa as immunomodulator
Abstract
Introduction
Chemical composition of black seed
Immunomodulatory effect of Nigella sativa on different immune cells
Effect of Nigella sativa on cellular immunity
Effect of Nigella sativa on humoral immunity
Effect of Nigella sativa on cytotoxic activity
Conclusion
Abbreviations
References
Chapter 15 Gastrointestinal abnormalities and Nigella sativa: A narrative review of preclinical and clinical studies
Abstract
Introduction
Preclinical studies
Landscape of clinical evidences on the use of Nigella sativa in patients with gastrointestinal disorders
Refractory coeliac disease
Ulcerative colitis
Functional dyspepsia
Hepatitis C
Nonalcoholic fatty liver disease
Summary
References
Chapter 16 Antiviral effects of black seeds: Effect on COVID-19
Abstract
Natural products as an important source of drug discovery
Nigella sativa and its medicinal properties
Viruses as important human pathogens
Concluding remarks
Acknowledgment
References
Chapter 17 Black seed (Nigella Sativa): Pharmacological and therapeutic applications in endocrine dysfunction
Abstract
Introduction
Nigella sativa in hypothyroidism
Nigella sativa and diabetes
Nigella sativa and reproduction
Nigella sativa and its influence on hypothalamus-pituitary-testis axis activity
Conclusion
References
Chapter 18 Nigella sativa and prevention of nephrotoxicity: A comprehensive update
Abstract
Introduction
Chemical composition of plant
Therapeutic properties of Nigella sativa
Renoprotective effects of Nigella sativa
Conclusion and future directions
References
Chapter 19 Nigella sativa: A promise for industrial and agricultural economic growth
Abstract
Introduction
Promises and current status of Nigella sativa in market
Pharmacognostical characteristics
Bioactive metabolites of Nigella sativa
Country based import and export of black seeds
Potential uses of Nigella sativa in agricultural economic growth
Potential of black seed market on form type
Nutritional value and applications of Nigella sativa in different Industries
Some commercial products of Nigella sativa already present in the market
Conclusions and future recommendations
References
Index

Andleeb Khan

Andleeb Khan (Ph.D.) is Assistant Professor at Jazan University, Saudi Arabia. She has completed her doctorate from Jamia Hamdard, New Delhi, India in Toxicology with specialization in natural and active constituents from plants for prevention of Alzheimer’s Disease. She has teaching and research experience of more than ten years in neurodegenerative disorders and their prevention with medicinal plants, their active principles and nanoformulations. She has published her research in national and international journals and contributed many book chapters with international publishers including Springer Nature and Elsevier. Currently, Dr. Khan is engaged in studying the molecular mechanism of Azheimer’s disease, Ischemic stroke, Parkinson’s Disease and their prevention by various active principles from natural sources and nanoformulations.

Affiliations and expertise

Assistant Professor, Jazan University, Saudi Arabia

Muneeb U Rehman

Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.

Affiliations and expertise

College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health