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Biothermodynamics, Part D

  • 1st Edition, Volume 492 - February 16, 2011
  • Latest edition
  • Editors: Michael L. Johnson, Jo M. Holt, Gary K. Ackers
  • Language: English

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally… Read more

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Description

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

Key features

  • Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules
  • Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research
  • Offers step-by-step lab instructions, including necessary equipment, from a global research community

Readership

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of contents

1. A Thermodynamic Approach for the Targeting of Nucleic Acid Structures Using Their Complementary Single Strands
Hui-Ting Lee, Caroline Carr, Hollie Siebler, Lela Waters, Irine Khutsishvili, Fany Iseka, Brian Domack, Chris M. Olsen, and Luis Marky

2. Thermodynamics of Biological Processes
Hernan G. Garcia, Jane Kondev, Nigel Orme, Julie Theriot and Rob Phillips

3. Protein stability in the presence of co-solutes
Luis Marcelo F. Holthauzen, Matthew Auton, Mikhail Sineva and Jorg Rosgen

4. Small Angle X-ray Scattering Studies of Peptide-Lipid Interactions using the Mouse Paneth Cell α-Defensin Cryptdin-4
Abhijit Mishra, Kenneth P. Tai, Nathan W. Schmidt, André J. Ouellette and Gerard C. L. Wong

5. Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery
Rebecca Strawn, Thomas Stockner, Milan Melichercik, Lihua Jin, Wei-Feng Xue, Jannette Carey and Rüdiger Ettrich

6. Using tryptophan fluorescence to measure the stability of membrane proteins folded in liposomes
C. Preston Moon1 and Karen G. Fleming

7. Non-B Conformations of CAG Repeats Using 2-aminopurine
Natalya N. Degtyareva and Jeffrey T. Petty

8. Disulfide bond-mediated passenger domain stalling as a structural probe of autotransporter outer membrane secretion in vivo
Jonathan P. Renn & Patricia L. Clark

9. Strategies for the Thermodynamic Characterization of Linked Binding/Local Folding Reactions Within the Native State: Application to the LID Domain of Adenylate Kinase from Escherichia coli
Travis P. Schrank, W. Austin Elam, Jing Li and Vincent J. Hilser

10. Fluorescence detected sedimentation in dilute and highly concentrated solutions
Jonathan S. Kingsbury and Thomas M. Laue

Product details

  • Edition: 1
  • Latest edition
  • Volume: 492
  • Published: February 25, 2011
  • Language: English

About the editors

MJ

Michael L. Johnson

Affiliations and expertise
University of Virginia Health Sciences Center, Charlottesville, USA

JH

Jo M. Holt

Affiliations and expertise
Washington University Medical Center, St. Louis, MO, USA

GA

Gary K. Ackers

Affiliations and expertise
Washington University School of Medicine, St. Louis, Mo, USA

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