Biotechnology in Healthcare, Volume 2

Applications and Initiatives

1st Edition - August 14, 2022
Editor: Debmalya Barh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 0 4 2 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 3 6 4 - 6

Biotechnology in Healthcare presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Biotechnology has revolutionized health… Read more

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Biotechnology in Healthcare presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Biotechnology has revolutionized healthcare in the last two decades by developing and introducing novel diagnostics, therapeutics, and preventive measures; whether it is noncommunicable or communicable disease, primary or secondary care, or public health, it has shown its immense potential to provide a solution to the healthcare providers, physicians, and allied health care professionals.
The second volume, Applications and Initiatives, contains 19 chapters focused on the applications of biotechnology related to public healthcare, hospital management, oncology, neurodegenerative and infectious diseases, regenerative medicine, IVF, clinical trials, precision food, FMGCs, PPCPs, pharmaceuticals, and smart technologies to monitor pandemic. Further, this volume also presents government initiatives and entrepreneurship challenges in healthcare biotechnology sector.
This is a valuable resource for students, biotechnologists, bioinformaticians, clinicians, and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.

Cover image
Title page
Table of Contents
Copyright
Dedication page
Contributors
About editor
Preface
Section I. Applications of biotechnology in healthcare
Chapter 1. Biotechnology in primary healthcare and hospital management
1. Introduction
2. Primary healthcare and its importance: current status in India
3. Biotechnology applications in primary healthcare
4. Biotechnology in hospital management
5. Biotechnology-based biosafety
6. Challenges and future prospects
Chapter 2. Biotechnology in public and rural health
1. Introduction
2. Biotechnology approaches to improve public and rural health
3. Advanced biotechnological achievements applied in rural areas
4. Environmental biotechnology applied to public and rural health
5. Future prospects
Chapter 3. Invertebrate models in translational research: lessons from Caenorhabditis elegans and Drosophila melanogaster
1. Introduction
2. Caenorhabditis elegans models for translational research
3. Drosophila models for translational research
4. Translational impact of invertebrate research
Glossary
Chapter 4. Biotechnology for diagnosis, prognosis, and monitoring cancer
1. Introduction
2. Types of liquid biopsy specimens
3. Chemical modifications to increase sensitivity in mutant detection
4. Technological approaches for circulating cell analysis
5. Technological approaches for extracellular vesicle analysis
6. Technological approaches for nucleic acid analysis
7. Clinical utility of liquid biopsy analysis
8. Concluding remarks and future perspectives
Chapter 5. Proteolysis-targeting chimeras (PROTACs) as novel biotechnology for cancer therapy
1. Introduction
2. Advantages and limitations of PROTACs in comparison with small molecule inhibitors
3. Small-molecule PROTAC degraders of the bromodomain and extraterminal domain (BET) proteins
4. PROTAC degrader of oncoprotein BCR-ABL1
5. PROTAC degrader of the Bcl-2 and Bcl-XL
6. PROTAC degrader of tyrosine kinase (BTK)
7. Degradation of interleukin-1 receptor-associated kinase 4 (IRAK4)
8. Degradation of casein kinase 2 (CK2) by PROTAC
9. Selective degradation of serine/threonine protein kinase 6, cyclin-dependent kinase (CDK6) by cereblon, VHL, and novel inhibitor of apoptosis (IAP)-recruiting PROTACs based on palbociclib
10. Targeted degradation of anaplastic lymphoma kinase by PROTACs
11. A potent and selective small-molecule degrader PROTAC SD-36 of signal transducer and activator of transcription 3 (STAT3)
12. PROTAC degrader of the human homolog of MDM2 (HDM2)
13. Other PROTAC degraders, SNIPERs, and macrocyclic PROTACs
14. Molecular glues
15. Principles and perspectives on the design of PROTACs
16. Conclusions and perspectives
Chapter 6. Biotechnology applications in neurodegenerative diseases
1. Introduction
2. Alzheimer's disease
3. Parkinson's disease
4. Amyotrophic lateral sclerosis
5. Huntington's disease
6. Biotechnological applications on neurodegenerative diseases
7. Stem cells therapy
8. Role of medicinal compounds in neurodegenerative diseases
9. Conclusions
Chapter 7. Basic biotechnology applications in viral diseases
1. Introduction
2. Diagnosis
3. Treatment
4. Limitations and future prospects
Chapter 8. Biotechnology applications in infectious disease
1. Recombinant protein-based vaccines
2. Monoclonal antibodies
3. Immunizations with non-viral gene delivery vectors
4. Immunizations with viral gene delivery vectors
5. Conclusions
Chapter 9. Biotechnology applications in regenerative medicine
1. Introduction
2. Conclusions and future direction
Chapter 10. Biotechnology in the process of assisted reproduction
1. Introduction
2. Biotechnology in andrology
3. Biotechnology in the IVF process
4. Early embryo development
5. Preimplantation embryo cultivation
6. Embryo transfer
Chapter 11. Biotechnology applications in clinical trials
1. Introduction
2. Gene therapy in clinical trials
3. Peptide and protein-based drugs in clinical trials
4. Conclusion
Chapter 12. Biotechnology applications in precision food
1. Introduction
2. Precision food for health
3. Recent trends of biotechnology in precision food
4. Recent trends in precision food
5. Challenges and future perspectives
Section II. Regulatory issues in healthcare biotechnology
Chapter 13. Mechanisms and applications of probiotics in healthcare industry
1. Introduction
2. Basic concept of probiotics
3. Sources of probiotic bacteria
4. Health benefits of probiotics
5. Guidelines for the evaluation of probiotics in food
6. Mode of action of probiotics
7. Probiotics in healthcare
8. Conclusions
Chapter 14. Applications of digital and smart technologies to control SARS-CoV-2 transmission, rapid diagnosis, and monitoring
1. Introduction
2. Smart and digital technologies
3. Digital and smart technologies for practical implementation
4. Integration of sectors (clinical, environmental, and emerging digital technologies for research purpose)
5. Comparison of digital technology implemented for pandemic monitoring in Western and Eastern culture
6. Risks of digital technology
7. Ethical perspective
8. Steps to ensure data safety
9. Future trends
10. Conclusion
Chapter 15. Biotechnology in cosmetics
1. Introduction
2. Skin and aging
3. Biotechnological products used in cosmetics
4. Microorganisms that attract attention in the cosmetics industry
5. Cell-based cosmetic approaches
6. Conclusion
Chapter 16. Biotechnology focuses on fast-moving consumer goods, pharmaceutical personal care products, medicines, and foods
1. Introduction
2. What are fast-moving consumer goods?
3. Biotechnology and FMCGs
4. What are personal care products, and the differences to PPCPs?
5. Biotechnology and PPCPs
6. What about pharmaceutical products?
7. Biotechnology and new pharmaceuticals products
8. Food biotechnology and health
9. Conclusions and perspectives
Chapter 17. Government initiatives and policies in healthcare biotechnology
1. Introduction
2. Healthcare biotechnology
3. Role of healthcare biotechnology in improvement of health
4. Government initiatives, policies, and regulations-related healthcare biotechnology
5. Conclusion
Chapter 18. Challenges and opportunities in healthcare biotechnology
1. Introduction to biotechnology in healthcare
2. Economic features of global biotechnology business
3. Opportunities and challenges in healthcare biotechnology
4. Sustainability of healthcare system
5. Conclusion
Chapter 19. Entrepreneurship in healthcare biotechnology
1. Introduction
2. The colors of biotechnology
3. Biotechnology entrepreneurship
4. Healthcare biotechnology
5. Challenges and opportunities in entrepreneurship healthcare biotechnology
6. Future roadmap
7. Conclusions
Index

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Debmalya Barh