Biotechnology and Safety Assessment
- 3rd Edition - July 29, 2002
- Imprint: Academic Press
- Editors: John A. Thomas, Roy L. Fuchs
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 3 9 9 2 6 1 - 1
- Hardback ISBN:9 7 8 - 0 - 1 2 - 6 8 8 7 2 1 - 1
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 2 8 1 8 - 2
A comprehensive treatise on new developments in biotechnology, the authors of Biotechnology and Safety Assessment, 3e, bring readers an up-to-date review of food safety issues, p… Read more
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Request a sales quoteA comprehensive treatise on new developments in biotechnology, the authors of Biotechnology and Safety Assessment, 3e, bring readers an up-to-date review of food safety issues, pre-clinical safety and development of new foods and drugs, plant biotechnology, food allergies and safety assessment, and consumer benefits with regard to genetically modified food.
Tomorrow's foods will be obtained from genetically modified crops, offering consumers higher nutritional value and more of it. Our medications will be obtained through a variety of biotechnological procedures yielding more potent and specific medications for diseases and vaccines. In order to make this view of the future come to light, John A. Thomas and Roy L. Fuchs have updated their classic in order to keep readers one step ahead.
Written by internationally recognized molecular biologists, plant agronomists, microbiologists, toxicologists, nutritionists, and regulatory authorities, this third edition is an excellent and authoritative resource, making it a valuable resource to any biomedical library or scientific bookshelf.
- Provides timely coverage on topics of agribiotechnology and biotherapeutics
- Describes the recent progress in genetically modified crops and their safety
- Presents an update of the newer developments in therapeutic agents
- Discusses role of genetically modified microorganisms in the development of new food products
- Outlines various global regulatory issues relating to GM crops
- Addresses environmental and ecological topics related to GM crops
Toxicologists, phamacologists, regulatory agency professionals, environmental scientists, and agricultural scientists
Contributors
Preface
Chapter 1. Using Plant Biotechnology to Reduce Allergens in Food: Status and Future Potential
Introduction
Characteristics of Food Allergens
Traditional Plant Breeding Methods for Reducing Allergenicity
Use of Genetic Engineering to Reduce Allergenic Potential
Concluding Remarks
References
Chapter 2. Experience with Biosafety Research and Postmarket Environmental Monitoring in Risk Management of Crops Derived from Plant Biotechnology
Introduction
End Points and Definitions
Regulatory Aspects
Biosafety Research on Virus-Resistant Sugar Beet
Using Biogeographical Data for Biosafety Research
Monitoring of Insect-Resistant Maize
Concluding Remarks: Linking Biosafety Research and Monitoring
References
Chapter 3. Safety Assessment of Foods and Food Ingredients Produced by Genetically Modified Microorganisms
Introduction
Issues in Food and Food Ingredients Produced From rDNA
Concepts in Safety Testing
Regulatory Requirements
Case Studies in Safety Assessment
Concluding Remarks
References
Chapter 4. Food Safety Assessment of Current and Future Plant Biotechnology Products
Introduction
Safety Evaluation and the Substantial Equivalence Paradigm
How are Genetically Modified Foods Evaluated for Food Safety?
Future Trends in Food Safety Assessments
Concluding Remarks and Future Prospects
References
Chapter 5. Plant Biotechnology Products with Direct Consumer Benefits
Introduction
Improved Nutritional Qualities
Products with Enhanced Quality Traits
Concluding Remarks
References
Chapter 6. Animal Feeds from Crops Derived through Biotechnology: Farm Animal Performance and Safety
Introduction
Crops Fed to Farm Animals in the United States
Characteristics of Intake and Digestion by Farm Animals
Performance, Health, and Nutrient Utilization for Farm Animals Consuming Biotechnology-Derived Crops
Composition of Meat, Milk, and Eggs from Farm Animals Consuming Biotechnology-Derived Crops
Detecting Plant Source Proteins and DNA in Animal Products
Concluding Remarks: Future Directions
References
Chapter 7. Preclinical Immunotoxicology Assessment of Cytokine Therapeutics
Introduction
Cytokines and Their Role in Health and Disease
Modulation of Cytokine Activity as a Therapeutic Modality
Clinical Toxicity Associated with Modulation of Cytokine Activity
Immunotoxicolcogy Assessment of Cytokine Therapeutics
Concluding Remarks
References
Chapter 8. Ecological Assessment of Crops Derived through Biotechnology
Introduction
Terminology
Ecological Risk Assessment Principles
Ecological Risk Assessment Principles for Genetically Modified Plants
Concluding Remarks
References
Chapter 9. Ribozyme Technology and Drug Development
Introduction
Nonenzymatic Antisense Oligonucleotides as Inhibitors of Specific Gene Expression
RNA-based Enzymes
Catalytic DNAs
Therapeutic Applications of Catalytic Oligonucleotides
Ribozyme Delivery, Pharmacokinetics, and Metabolism
Concluding Remarks: Future Prospects
References
Chapter 10. Biotherapeutics: Current Status and Future Directions
Introduction
Recombinant Proteins: Approved for Clinical Use
Interferon Alfa
Recombinant Proteins in Clinical Development
Natural Biological Response Modifiers
Chemically Defined Biological Response Modifiers
Combination Chemotherapy, Immunotherapy, and Cellular Therapy
Concluding Remarks
References
Chapter 11. Food Allergy Assessment for Products Derived through Plant Biotechnology
Introduction to Food Allergies and Allergens
Novel Proteins: Justification for Allergenicity Assessment
Allergy Assessment in the Gene Discovery Phase
Decision Tree Approach: The 2001 FAO/WHO Decision Tree
Example Applications of Allergenicity Assessment
Concluding Remarks
References
Chapter 12. Biotechnology: Safety Evaluation of Biotherapeutics and Agribiotechnology Products
Introduction
Biotherapeutics
Agribiotechnology
Concluding Remarks
References
Chapter 13. The Potential of Plant Biotechnology for Developing Countries
Introduction
Agriculture in Africa
African Crops and their Problems
Vaccines for Africa
Genetically Modified Crops in South Africa
Genetically Modified Crops in Developing Countries
The Anti-GMO Lobby and Developing Countries
Future Directions
Concluding Remarks
References
Chapter 14. Preclinical Safety Evaluation of Vaccines
Introduction
Regulatory Framework
Outline of the Proposed Studies
Concluding Remarks
References
Chapter 15. Gene Flow from Transgenic Plants
Introduction
Initial Hybrid Formation
Transgene Introgression
Transgene Spread
Concluding Remarks
References
Chapter 16. Safety Assessment of Insect-Protected Cotton
Introduction
Molecular Characterization of Bollgard Cotton
Cry1Ac and NPT II Protein Levels in Bollgard Cotton Plants
Safety Assessment of the Cry1Ac and NPT II Proteins in Bollgard Cotton
Compositional Analysis and Nutritional Assessment of Bollgard Cotton
Horizontal Gene Transfer and the Assessment of Marker Genes
Environmental Assessment
Concluding Remarks
References
- Edition: 3
- Published: July 29, 2002
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780123992611
- Hardback ISBN: 9780126887211
- eBook ISBN: 9780080528182
JT
John A. Thomas
Affiliations and expertise
University of Texas Health Sciece Center, San Antonio, U.S.A.RF
Roy L. Fuchs
Affiliations and expertise
Mosanto Company, St. Louis, Missouri, U.S.A.Read Biotechnology and Safety Assessment on ScienceDirect