Biotechnological Strategies for the Treatment of Gluten Intolerance
- 1st Edition - May 11, 2021
- Imprint: Academic Press
- Editor: Mauro Rossi
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 9 4 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 4 1 - 2
Biotechnological Strategies for the Treatment of Gluten Intolerance provides a comprehensive overview of a wide range of biotechnological approaches that will further resear… Read more
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Request a sales quoteBiotechnological Strategies for the Treatment of Gluten Intolerance provides a comprehensive overview of a wide range of biotechnological approaches that will further research and upon implementation improve the quality of life of this population. Gluten intolerance is a heterogeneous condition with varying levels of sensitivity that have typically been treated with a gluten free diet, but this book provides new and exciting biotechnological approaches that affect diet as well as non-dietary approaches. The reference describes the varying levels of sensitivity and explores symptoms beyond the intestines for a complete overview of the spectrum of sensitivity. The impact of diversity of wheat species, gluten quality and the nutritional values of gluten free products are extensively discussed. This reference is perfect for researchers and clinicians that want to further treatment options for those suffering from gluten sensitivity.
- Provides an innovative scenario of gluten intolerance, on the basis of recent epidemiological and pathogenetic findings
- Highlights the knowledge of biotechnological strategies to overcome the classical gluten free diet
- Highlights innovative immune approaches for the management of gluten intolerance
Gastroenterology Researchers, Gastroenterologists. Nutritionists, Food Industry Experts
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editor
- Preface
- Section 1: Gluten Intolerance: The Triggering Agents
- Chapter 1. Epidemiology and pathogenesis of celiac disease and non-celiac gluten (wheat) sensitivity
- Abstract
- 1.1 Overview of gluten-related disorders
- 1.2 Epidemiology
- 1.3 Pathogenesis
- References
- Chapter 2. Molecular triggers of non-celiac wheat sensitivity
- Abstract
- 2.1 Introduction
- 2.2 Celiac disease and wheat allergy as paragons of gluten sensitivity
- 2.3 Non-celiac gluten/wheat sensitivity as a newcomer
- 2.4 Molecular triggers of NCWS: understanding the available evidence
- 2.5 Conclusions
- References
- Chapter 3. Gut microbiota in the etiopathogenesis of celiac disease
- Abstract
- 3.1 Celiac disease: not only genes and gluten matters
- 3.2 Cross talk between the host and microbiota early in life
- 3.3 Cross-sectional studies on CeD and the microbiome
- 3.4 Prospective studies linking gut microbiota to CeD development
- 3.5 Potential mechanism of action of intestinal microbiota in CeD
- 3.6 Conclusions and perspectives
- Acknowledgments
- References
- Section 2: Beyond the Intestine
- Chapter 4. Neurological manifestations of gluten sensitivity
- Abstract
- 4.1 Gluten ataxia
- 4.2 Gluten neuropathy
- 4.3 Gluten encephalopathy and the cognitive impact of gluten sensitivity
- 4.4 Celiac disease and autism
- 4.5 Pathophysiology
- References
- Chapter 5. Gluten intolerance and autoimmunity
- Abstract
- 5.1 Introduction
- 5.2 Mechanisms leading to autoimmunity in celiac disease
- 5.3 Mechanisms leading to tissue damage
- 5.4 Clinical aspects
- 5.5 Autoimmunity and non-celiac gluten sensitivity
- 5.6 Conclusions
- References
- Section 3: New Dietary Approaches
- Chapter 6. Gluten quantity and quality in wheat and in wheat-derived products
- Abstract
- 6.1 Introduction
- 6.2 Wheat in the Neolithic package
- 6.3 Diversity of wheat species
- 6.4 Domestication of wheat species
- 6.5 Wheat breeding
- 6.6 Gluten and other prolamins in wheat
- 6.7 Wheat gluten and end-use quality
- 6.8 Gluten diversity related to celiac disease
- 6.9 What we eat: diversity in wheat-derived products
- 6.10 Wheat/gluten consumption and (gastrointestinal) health
- 6.11 Perspectives
- Acknowledgments
- Conflict of interest
- References
- Chapter 7. Toward an innovative gluten-free diet
- Abstract
- 7.1 Introduction
- 7.2 Is a gluten-free diet nutritionally adequate?
- 7.3 Nutritional composition of GFPs as compared to GCCs
- 7.4 Strategies to avoid nutritional imbalances in a GF diet
- 7.5 Concluding remarks
- References
- Chapter 8. Detoxification of wheat proteins by enzymatic technology
- Abstract
- 8.1 Introduction
- 8.2 Wheat proteins and wheat-related diseases
- 8.3 Technological approaches to detoxify wheat proteins
- 8.4 Nutritional and health advantages of wheat-detoxified foodstuffs
- 8.5 Current legislation and challenges for wheat enzymatic detoxification
- References
- Chapter 9. Engineering wheat for gluten safe
- Abstract
- 9.1 Introduction
- 9.2 Gluten intolerances and triggering agents
- 9.3 Breeding toward gluten-safe wheat
- 9.4 Downregulation of gluten proteins by RNAi
- 9.5 Gene editing
- 9.6 Applications of CRISPR/Cas9 for gluten engineering
- 9.7 Future perspectives
- Acknowledgments
- References
- Section 4: Nondietary Approaches
- Chapter 10. Oral enzyme strategy in celiac disease
- Abstract
- 10.1 Introduction
- 10.2 Gluten as a trigger for autoimmunity
- 10.3 Sources of gluten-degrading enzymes
- 10.4 Cocktails of gluten hydrolysis enzymes
- 10.5 Engineered gluten-degrading enzymes
- 10.6 Technological improvements in gluten-degrading enzymes
- Funding
- References
- Chapter 11. Therapeutic targets based on the modulation of immune function by gut bacteria
- Abstract
- 11.1 Introduction
- 11.2 Gluten-free diet is an effective but imperfect therapy for CeD
- 11.3 Why consider microbial therapeutics in CeD?
- 11.4 Current microbial therapies in CeD: are we ready for a clinical recommendation?
- 11.5 Next generation of microbial therapeutics
- 11.6 Conclusions
- References
- Chapter 12. Gluten peptide immunomodulatory strategies
- Abstract
- 12.1 Introduction
- 12.2 Celiac disease: a food intolerance with a strong autoimmune component
- 12.3 CD4+ T cells have a central role in the inflammatory response elicited by gluten proteins
- 12.4 Peptide-based immunotherapy in celiac disease: from the identification of dominant gluten T-cell epitopes to the design of a potential vaccine strategy
- 12.5 Antigen-based immunotherapies in allergic and autoimmune diseases
- 12.6 Conclusion
- References
- Index
- Edition: 1
- Published: May 11, 2021
- Imprint: Academic Press
- No. of pages: 278
- Language: English
- Paperback ISBN: 9780128215944
- eBook ISBN: 9780128217412
MR
Mauro Rossi
Mauro Rossi is Research Director at the Italian National Research Council (CNR)—Institute of Food Sciences (ISA) and Head of the Immunobiology Unit. He has 30 years of work experience in the field of the Biochemistry and Immunology of the small intestine. In the 1990s, he worked in the laboratories of Professor Auricchio (University “Federico II” of Naples, Italy), Noren (Panum Institute, Copenhagen, Denmark), Semenza (ETH, Zurich, Switzerland) on the biosynthesis of intestinal disaccharidases and lactose intolerance (adult-type hypolactasia), and Professor Londei (Kennedy Institute of Rheumatology, London, United Kingdom) on the cellular and molecular aspects of antigen-specific T-cell activation. His research focuses on the immunology of the small intestine, mainly on the mechanisms of tolerance to food antigens and on the development of microbiological and enzymatic strategies to downregulate the intestinal hypersensitivity to wheat gluten. He is also involved in basic and oriented applied research on probiotics.
Affiliations and expertise
Research Director, CNR-ISA, Avellino, ItalyRead Biotechnological Strategies for the Treatment of Gluten Intolerance on ScienceDirect