Biosynthesis of Antibiotics

List of Contributors

Preface


1. Microbial Processes for the Preparation of Radioactive Antibiotics

I. Introduction

II. Microbial Methods Used in the Preparation of Radioactive Antibiotics

III. Some Radioactive Antibiotics Prepared by Microbial Processes

IV. Summary

References


2. Biosynthesis of Penicillins and Cephalosporins

I. Introduction

II. Biosynthesis of Penicillins by Penicillium

III. Penicillin Acylases

IV. New Penicillins

V. Penicillin Ν Biosynthesis by Cephalosporium and Emericellopsis

VI. Cephalosporin C Biosynthesis by Cephalosporium

VII. Derivatives of Cephalosporin C (New Cephalosporins)

VIII. Enzymes Which Act on Cephalosporin C

IX. Hypothetical Pathway of Cephalosporin C and Penicillin Biosynthesis

X. Summary

References


3. Biosynthesis of Tetracycline Antibiotics

I. Introduction

II. General Considerations

III. Origin of Carbon Atoms in the Tetracycline Molecule

IV. Mechanisms and Intermediates

V. Cell-Free Systems

VI. Summary

References


4. Biosynthesis of Streptomycin

I. Introduction

II. Biosynthesis of Streptidine

III. Biosynthesis of 2-Deoxy-2-methylamino-L-glucose

IV. Biosynthesis of Streptose

V. Transglycosylation Reactions in the Formation of Streptomycin

References


5. Biosynthesis of Polyacetylenes in Fungi

I. Introduction

II. Precursor Units

III. Origin of Triple Bonds

IV. Dynamics of Polyacetylene Synthesis

V. Prospects

References


6. Biochemistry of the Macrolide Antibiotics

I. Introduction

II. Structural Variation within the Macrolide Group

III. Mechanisms Implicated in Macrolide Biogenesis

IV. Sources of the Macrolide Precursors

V. Biological Role of the Macrolides

References

Author Index

Subject Index