Biosensor Based Advanced Cancer Diagnostics

From Lab to Clinics

1st Edition - August 25, 2021
Imprint: Academic Press
Editors: Raju Khan, Arpana Parihar, S.K. Sanghi
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 4 2 4 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 6 5 1 - 2

Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient’s life expectancy. Recent advances in bi… Read more

Biosensor Based Advanced Cancer Diagnostics

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Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient’s life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology.

Biosensor Based Advanced Cancer Diagnostics
helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editors
Chapter 1. Cancer: A sui generis threat and its global impact
Abstract
1.1 Introduction
1.2 Causes of cancer
1.3 Causes and risk factors of cancer
1.4 Early detection and management
1.5 Current management
1.6 Conclusions and future prospects
Conflict of interest
List of abbreviations
References
Chapter 2. Types of cancer diagnostics, the current achievements, and challenges
Abstract
2.1 Introduction
2.2 What is cancer
2.3 What is diagnostics
2.4 Importance of diagnostics
2.5 Different types of cancer diagnostics
2.6 Factors that can amend cancer diagnostics
2.7 Diagnostics for some typical and mostly observed cancer types
2.8 Achievements, challenges, and future aim of cancer diagnostics
Acknowledgments
Conflict of interest
References
Chapter 3. Biomarkers associated with different types of cancer as a potential candidate for early diagnosis of oncological disorders
Abstract
3.1 Introduction
3.2 Cancer biomarkers
3.3 Concluding remarks
References
Chapter 4. Biosensors: concept and importance in point-of-care disease diagnosis
Abstract
4.1 Introduction
4.2 POC biosensors for cancer diagnosis
4.3 Application of biomaterials in biosensors
4.4 New trends in POC biosensors design
4.5 Commercially available POC biosensors for cancer diagnosis
4.6 Future perspectives
Acknowledgments
References
Chapter 5. Early detection of lung cancer biomarkers through biosensor
Abstract
5.1 Introduction
5.2 Lung cancer biomarkers
5.3 Biosensors for lung cancer biomarker detection
5.4 Conclusion and future perspectives
References
Chapter 6. Biosensor-based early diagnosis of hepatic cancer
Abstract
6.1 Introduction
6.2 Hepatocellular carcinoma
6.3 Biosensors in cancer
6.4 Clinical studies on HCC serum biomarkers and their sensor-based detection
6.5 Other clinically relevant biomarkers for HCC
6.6 Conclusion
6.7 Future Prospects
References
Chapter 7. Scope and applications of biosensors in early detection of oropharyngeal cancers
Abstract
7.1 Introduction
7.2 DNA (ct DNA)
7.3 Tumor necrosis factor
7.4 Epidermal growth factor receptor
7.5 Exosomes
7.6 Cyfra 21-1
7.7 Conclusion
References
Chapter 8. Electrochemical biosensors for early detection of cancer
Abstract
8.1 Introduction
8.2 Biosensors
8.3 Electrochemical biosensors
8.4 Conclusion
Acknowledgments
References
Further reading
Chapter 9. Colorimetric technique-based biosensors for early detection of cancer
Abstract
9.1 Introduction
9.2 Colorimetric-based strategy
9.3 Nanomaterial-based approach
9.4 DNA-based approach
9.5 Other approaches
9.6 Conclusion
References
Further reading
Chapter 10. Magnetic properties-based biosensors for early detection of cancer
Abstract
10.1 Introduction
10.2 Biosensors and their types
10.3 Cancer detection and diagnostics
10.4 Applications of a magnetic properties-based biosensor for cancer detection
10.5 Conclusion
References
Chapter 11. Next generation biosensors as a cancer diagnostic tool
Abstract
11.1 Introduction
11.2 Biosensor transducers
11.3 Biosensors for cancer biomarker detection
11.4 Conclusion and discussion
References
Chapter 12. Microfluidics-based devices and their role on point-of-care testing
Abstract
12.1 Introduction
12.2 Point-of-care devices
12.3 Nanoengineered materials
12.4 Microfluidic devices based on specific substrates
12.5 Microfluidic-based point-of-care devices for cancer diagnosing
12.6 Current trends and future prospects
12.7 Summary
References
Further reading
Chapter 13. Graphene-based devices for cancer diagnosis
Abstract
13.1 Introduction
13.2 Cancer biomarkers
13.3 Graphene and its derivatives
13.4 Graphene-based nanomaterials in cancer diagnosis
13.5 Functionalization of graphene for sensing application
13.6 Graphene material-based sensors
13.7 Conclusion
References
Chapter 14. Role of biosensor-based devices for diagnosis of nononcological disorders
Abstract
14.1 Introduction
14.2 Biosensors for infectious diseases
14.3 Recent challenges and future perspectives
14.4 Conclusion
References
Chapter 15. Biosensor-based early diagnosis of gastric cancer
Abstract
15.1 Introduction
15.2 Biomarkers for gastric cancer
15.3 Biosensor and gastric cancer
15.4 Conclusion and future perspectives
References
Chapter 16. 3D-printed device with integrated biosensors for biomedical applications
Abstract
16.1 Introduction
16.2 Basics of biosensors
16.3 Types of biosensors
16.4 History of 3D-printed biosensors
16.5 Need of integrated biosensors
16.6 Commercial biosensors in the market
16.7 Different materials used in 3D-printed biosensors
16.8 Types of 3D-printing techniques
16.9 Applications of 3D-printed biosensors
16.10 Advantages of 3D-printed biosensors
16.11 Disadvantages of 3D-printed biosensors
16.12 Some of the case studies of biosensors
16.13 Major breakthrough in the field of personalized medicines
16.14 3D biosensors and cancer
16.15 Challenges faced by researchers
16.16 Regulatory aspects of biosensors
16.17 3D-printed biosensors in Covid-19
16.18 Future of 3D-integrated biosensors
16.19 Conclusion
References
Further reading
Chapter 17. Novel paper-based diagnostic devices for early detection of cancer
Abstract
17.1 Introduction
17.2 Formats of paper-based analytical devices
17.3 Fabrication and development of paper-based analytical devices
17.4 Diagnostic technologies
17.5 Current limitations
17.6 Conclusion and future perspectives
References
Further reading
Chapter 18. Emerging technologies for salivary biomarkers in cancer diagnostics
Abstract
18.1 Introduction
18.2 Technologies for discovery of salivary biomarkers
18.3 Point-of-care technologies for detection of salivary biomarkers
18.4 Challenges in translating salivary biomarkers to the clinics
18.5 Conclusion
Acknowledgment
References
Chapter 19. Two-dimensional nanomaterials for cancer application
Abstract
19.1 Introduction
19.2 Synthesis of two-dimensional nanomaterials
19.3 Two-dimensional nanomaterials for cancer applications
Conclusion
References
Chapter 20. Challenges and future prospects and commercial viability of biosensor-based devices for disease diagnosis
Abstract
20.1 Introduction
20.2 Biosensor classification for disease diagnosis
20.3 Biomarkers
20.4 Application of biosensors in disease detection
20.5 The market trend of biosensors in disease detection
20.6 Research trends of novel biosensors in disease detection
20.7 Advantages of use of biosensors in the field of disease detection
20.8 Designing and advancements of biosensor design
20.9 Biosensor ligands used for disease diagnosis
20.10 Detection of pathogenic organisms in diseases by biosensors
20.11 Nanoscience and disease biosensor
20.12 Conclusion
20.13 Future aspects
References
Chapter 21. Cancer diagnosis by biosensor-based devices: types and challenges
Abstract
21.1 Introduction
21.2 Disadvantages of conventional methods of cancer detection
21.3 Cancer biomarkers
21.4 Need of biosensors for cancer diagnosis
21.5 Fabrication strategies for cancer biosensors
21.6 Biosensors for cancer detection
21.7 Structure of cancer biosensor
21.8 Novel biosensors
21.9 Cell and tissue-based biosensors
21.10 Biosensors and nanotechnology
21.11 Challenges
21.12 Future aspects
References
Chapter 22. Miniaturized devices for point-of-care testing/miniaturization and integration with microfluidic systems
Abstract
22.1 Introduction
22.2 Detection of infectious and chronic diseases
22.3 Role of nanotechnology in the development of miniaturized devices
22.4 Integration of microfluidics with miniaturized point-of-care systems
22.5 Microfluidics as an emerging platform for point-of-care diagnosis
22.6 Conclusion
References
Chapter 23. Integrated low-cost biosensor for rapid and point-of-care cancer diagnosis
Abstract
23.1 Introduction
23.2 Cancer biomarkers
23.3 New low-cost point-of-care diagnostics for cancer detection
23.4 Conclusion
References
Chapter 24. Scope of biosensors, commercial aspects, and miniaturized devices for point-of-care testing from lab to clinics applications
Abstract
24.1 Introduction
24.2 Scope of biosensors
24.3 Cancer biomarker detection
24.4 Biomarkers for predicting the outcome of various cancer immunotherapies
24.5 Miniaturized devices for point-of-care testing from lab to clinical applications
24.6 Miniaturized point-of-care biosensor for cancer diagnosis
24.7 Current status of point-of-care cancer diagnostic devices
24.8 Global market of point-of-care devices
24.9 Limitations and challenges in cancer diagnostics
24.10 Conclusions and future prospects
Acknowledgments
References
Index

Raju Khan

Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.

Affiliations and expertise

Senior Principal Scientist & Professor, CSIR-Advanced Materials & Processes Research Institute, Bhopal, Madhya Pradesh, India

Arpana Parihar

Arpana Parihar is a DST Scientist B at CSIR-Advanced Materials and Processes Research Institute (AMPRI), Bhopal, India. She has 8 years of research and teaching experience and her current research interests include fabrication (Micro/Nano-fabrication) of Bio-devices/bio-medical POCT Devices for early diagnosis of cancer and infectious disease. She has gained significant expertise in the field of 3D cell culture, drug designing, tissue engineering, photodynamic therapy, molecular dynamic simulations, and immunoinformatics.

Affiliations and expertise

Industrial Waste Utilization, Nano and Biomaterials, CSIR-Advanced, Materials and Processes, Research Institute (AMPRI), Bhopal, Madhya, Pradesh, India

S.K. Sanghi

Sunil Kumar Sanghi was working as Chief Scientist, Professor and head at Microfluidics & MEMS Centre, CSIR-Advanced Materials and Processes Research Institute, Bhopal, India. His past research areas were development of manual and automated procedures for all kinds of analytes in biomedical, pharmaceutical and environmental samples using micro liquid, capillary gas chromatographic and capillary electrophoretic separation techniques in combination with sample preparation, derivatization and reaction-detection systems, micro-chip-based separation under the concept of lab-on-a-chip. Dr. Sanghi has successfully completed several International and national collaborative R & D projects viz. Indo- European Union, Indo – French, NMITLI etc. He was awarded the reputed Marie Curie Fellowship of European Union, and worked as a visiting scientist for three years at the University of Amsterdam and Institute Curie, Paris. He holds an experience of 35 years in R&D and teaching. Recently, Dr. Sanghi has received the National Meritorious Innovation Award 2021 from Government of India.

Affiliations and expertise

Chief Scientist & Head, Microfluidics & MEMS Centre & Materials for Radiation Shielding and Cement free Concrete CSIR-Advanced Materials and Processes Research Institute (AMPRI), India.

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Biosensor Based Advanced Cancer Diagnostics

From Lab to Clinics

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