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Bioresorbable Polymers for Biomedical Applications
From Fundamentals to Translational Medicine
1st Edition - August 24, 2016
Editors: Giuseppe Perale, Jöns Hilborn
Hardback ISBN:9780081002629
9 7 8 - 0 - 0 8 - 1 0 0 2 6 2 - 9
eBook ISBN:9780081002667
9 7 8 - 0 - 0 8 - 1 0 0 2 6 6 - 7
Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine provides readers with an overview of bioresorbable polymeric materials in the… Read more
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Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine provides readers with an overview of bioresorbable polymeric materials in the biomedical field. A useful resource for materials scientists in industry and academia, offering information on the fundamentals and considerations, synthesis and processing, and the clinical and R and D applications of bioresorbable polymers for biomedical applications.
Focuses on biomedical applications of bioresorbable polymers
Features a comprehensive range of topics including fundamentals, synthesis, processing, and applications
Provides balanced coverage of the field with contributions from academia and industry
Includes clinical and R and D applications of bioresorbable polymers for biomedical applications
Engineers, researchers in the pharmaceutical and bioengineering fields; Academics and students in the fields of biomaterials, drug delivery, and pharmacology.
Related titles
Dedication
List of contributors
Woodhead Publishing Series in Biomaterials
Foreword
Part One. Fundamentals and considerations of bioresorbable polymers for biomedical applications
1. Introduction to bioresorbable polymers for biomedical applications
1.1. General concepts
1.2. History of biopolymers technology
1.3. State of art
1.4. Future trends
2. Natural polymers: A source of inspiration
2.1. Introduction
2.2. Typical production processes for biomaterial synthesis
2.3. Exceptional material properties found in nature
2.4. Natural biomaterials and mimics thereof used for tissue engineering
2.5. Bioadhesives and medical glues
2.6. Polymers used in drug delivery/release systems
2.7. Conclusions
3. Bioresorbability of polymers: Chemistry, mechanisms, and modeling
3.1. Introduction
3.2. Degradation pathway and factors affecting degradation rate
3.3. Modeling degradation of bioresorbable polymers
4. The innate immune response: A key factor in biocompatibility
4.1. Immune system
4.2. Innate immunity
4.3. Complement system
4.4. The contact/kallikrein and coagulation systems
4.5. Thromboinflammation
4.6. Innate immunity activation on artificial material surfaces
4.7. Foreign body reactions on biomaterials
4.8. Degradation of commonly used resorbable polymers
4.9. Predicted activation of the innate immune system during degradation
4.10. Examples of involvement of adaptive immunity in the response to biomaterials
4.11. Conclusions
5. Form and function of resorbable materials–based medical devices
5.1. Definitions
5.2. Introduction
5.3. Form and function: target tissue mechanical properties and device function as inputs for tailoring the polymer mechanical properties
6. Quality management and safety of bioresorbable polymers for biomedical applications
6.1. Introduction and fields of application
6.2. Classification of biomedical products made with bioabsorbable polymers
6.3. Safety management
6.4. Management systems
6.5. Choice of raw material and quality control
7. Bringing bioresorbable polymers to market
7.1. Introduction
7.2. Production process
7.3. Regulatory aspects
7.4. Conclusions
Part Two. Synthesis and processing of bioresorbable polymeric materials for medical applications
8. Synthesis of bioresorbable polymers for medical applications
8.1. Introduction
8.2. Synthesis of raw materials
8.3. Synthesis of polymers
8.4. Polymer quality control
8.5. Degradation behavior
8.6. Polymer characterization
8.7. Novel ROP processes
8.8. Conclusions
9. Processing and production of bioresorbable polymer scaffolds for tissue engineering
9.1. Introduction
9.2. Scaffold fabrication
9.3. Conclusions and Future Directions
10. Synthesis and processing of hydrogels for medical applications
10.1. Introduction
10.2. Network structure and fundamental parameters
10.3. Hydrogel design features
10.4. Swelling behavior
10.5. Diffusion
10.6. Gelation
10.7. Physical cross-links
10.8. Chemical cross-links
10.9. Degradation
10.10. Degradation mechanisms
11. Bioresorbable polymer microparticles in the medical and pharmaceutical fields
11.1. Introduction
11.2. Types of bioresorbable polymers used for microparticles
11.3. Methods to prepare bioresorbable polymer microparticles
11.4. Important properties of bioresorbable polymer microparticles
11.5. Methods of application
11.6. Medical and pharmaceutical applications of bioresorbable polymer microparticles
11.7. Conclusions
12. Bioresorbable polymer nanoparticles in the medical and pharmaceutical fields: A promising field
12.1. Introduction
12.2. Bioresorbable polymer materials
12.3. Synthesis of polymer nanoparticles
12.4. Applications of bioresorbable polymer nanoparticles in medical and pharmaceutical fields
12.5. Use of nanoparticles: hurdles
13. Improving the pharmacodynamic and pharmacological profile of bioactive molecules using biopolymers
13.1. Introduction to pharmacodynamics of bioactive molecules
13.2. Nanobiomaterials as a promising delivery tool
13.3. General consideration on delivery strategy in the nervous system
13.4. Conclusions
14. Click chemistry for improving properties of bioresorbable polymers for medical applications
14.1. Introduction
14.2. Functionalization strategies
14.3. Case study 1: RGD peptide functionalization to improve cell adhesion
14.4. Case study 2: tunable drug delivery from injectable polymeric networks
14.5. Case study 3: in vivo tracking of degradation using noninvasive fluorescence imaging
14.6. Conclusions and future trends
15. Bioresorbable polymers for bioprinting applications
15.1. Introduction
15.2. Bioprinting platforms
15.3. Features of printable polymers
15.4. Examples of bioprinted tissues with various bioinks
15.5. Future perspective and discussion
Part Three. Clinical and research and development (R&D) applications of bioresorbable polymers
16. Cell delivery for regenerative medicine by using bioresorbable polymers
16.1. Introduction: cell delivery and regenerative medicine
16.2. Advantages of using a vehicle for cell delivery
16.3. Bioresorbable scaffolds for cell delivery: the tissue engineering approach
16.4. Design of bioresorbable constructs for cell delivery and tissue regeneration
16.5. Regulatory and clinical aspects in designing bioresorbable polymers for cell delivery
16.6. Challenges and future perspectives
17. Applications of bioresorbable polymers in the skeletal systems (cartilages, tendons, bones)
17.1. Introduction
17.2. Cartilages
17.3. Ligaments and tendons
17.4. Bones
17.5. Conclusions and future perspectives
18. Applications of bioresorbable polymers in skin and eardrum
18.1. Introduction
18.2. Skin
18.3. Tympanic membrane
18.4. Conclusions
19. Bioresorbable polymers for next-generation cardiac scaffolds
19.1. Introduction
19.2. Bioresorbable polymers for cardiac repair after MI
19.3. Bioresorbable drug delivery systems for myocardial tissue engineering
19.4. Conclusions and future prospects
20. Application of bioresorbable polymers in muscular system
20.1. Skeletal muscle tissue
20.2. Tissue engineering of muscle
20.3. Conclusions
21. Ocular applications of bioresorbable polymers—from basic research to clinical trials
21.1. Introduction
21.2. Anatomy of the eye
21.3. Bioresorbable polymeric drug delivery systems to the eye
21.4. Bioresorbable polymers for the treatment of corneal blindness
21.5. Vitreous substitutes
21.6. Retinal implants
21.7. Optic nerve
21.8. Conclusions
22. Applications of bioresorbable polymers in the central nervous system
22.1. Pathophysiology and treatment strategies
22.2. Spinal cord injuries and treatment strategies
22.3. Therapeutic potential of biomaterials
22.4. Biomaterials in clinical research
22.5. Conclusions
23. Engineering airways
23.1. Introduction
23.2. Anatomical overview of the airways: structure and histology
23.3. Tissue engineering of airway epithelium
23.4. Tissue engineering of trachea
23.5. Conclusions
Conclusions
Index
No. of pages: 628
Language: English
Published: August 24, 2016
Imprint: Woodhead Publishing
Hardback ISBN: 9780081002629
eBook ISBN: 9780081002667
GP
Giuseppe Perale
Giuseppe Perale is currently Professor of Regenerative Medicine at the Faculty of Biomedical Sciences of the University of Southern Switzerland (USI) in Lugano, Switzerland, and visiting Professor at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in Vienna, Austria
Affiliations and expertise
Professor of Regenerative Medicine, Faculty of Biomedical Sciences, University of Southern Switzerland (USI), Switzerland; Visiting Professor, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
JH
Jöns Hilborn
Jöns Hilborn is the head of the Polymer Chemistry program at the Department of Materials Chemistry, Uppsala University in Sweden and President and co-founder of “Tissue Engineering and Regenerative Medicine International Society” (TERMIS)
Affiliations and expertise
Department of Materials Chemistry, Uppsala University, Sweden