
Bioresorbable Polymers for Biomedical Applications
From Fundamentals to Translational Medicine
- 1st Edition - August 24, 2016
- Imprint: Woodhead Publishing
- Editors: Giuseppe Perale, Jöns Hilborn
- Language: English
- Hardback ISBN:9 7 8 - 0 - 0 8 - 1 0 0 2 6 2 - 9
- eBook ISBN:9 7 8 - 0 - 0 8 - 1 0 0 2 6 6 - 7
Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine provides readers with an overview of bioresorbable polymeric materials in the biome… Read more

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Request a sales quoteBioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine provides readers with an overview of bioresorbable polymeric materials in the biomedical field. A useful resource for materials scientists in industry and academia, offering information on the fundamentals and considerations, synthesis and processing, and the clinical and R and D applications of bioresorbable polymers for biomedical applications.
- Focuses on biomedical applications of bioresorbable polymers
- Features a comprehensive range of topics including fundamentals, synthesis, processing, and applications
- Provides balanced coverage of the field with contributions from academia and industry
- Includes clinical and R and D applications of bioresorbable polymers for biomedical applications
Engineers, researchers in the pharmaceutical and bioengineering fields; Academics and students in the fields of biomaterials, drug delivery, and pharmacology.
- Related titles
- Dedication
- List of contributors
- Woodhead Publishing Series in Biomaterials
- Foreword
- Part One. Fundamentals and considerations of bioresorbable polymers for biomedical applications
- 1. Introduction to bioresorbable polymers for biomedical applications
- 1.1. General concepts
- 1.2. History of biopolymers technology
- 1.3. State of art
- 1.4. Future trends
- 2. Natural polymers: A source of inspiration
- 2.1. Introduction
- 2.2. Typical production processes for biomaterial synthesis
- 2.3. Exceptional material properties found in nature
- 2.4. Natural biomaterials and mimics thereof used for tissue engineering
- 2.5. Bioadhesives and medical glues
- 2.6. Polymers used in drug delivery/release systems
- 2.7. Conclusions
- 3. Bioresorbability of polymers: Chemistry, mechanisms, and modeling
- 3.1. Introduction
- 3.2. Degradation pathway and factors affecting degradation rate
- 3.3. Modeling degradation of bioresorbable polymers
- 4. The innate immune response: A key factor in biocompatibility
- 4.1. Immune system
- 4.2. Innate immunity
- 4.3. Complement system
- 4.4. The contact/kallikrein and coagulation systems
- 4.5. Thromboinflammation
- 4.6. Innate immunity activation on artificial material surfaces
- 4.7. Foreign body reactions on biomaterials
- 4.8. Degradation of commonly used resorbable polymers
- 4.9. Predicted activation of the innate immune system during degradation
- 4.10. Examples of involvement of adaptive immunity in the response to biomaterials
- 4.11. Conclusions
- 5. Form and function of resorbable materials–based medical devices
- 5.1. Definitions
- 5.2. Introduction
- 5.3. Form and function: target tissue mechanical properties and device function as inputs for tailoring the polymer mechanical properties
- 6. Quality management and safety of bioresorbable polymers for biomedical applications
- 6.1. Introduction and fields of application
- 6.2. Classification of biomedical products made with bioabsorbable polymers
- 6.3. Safety management
- 6.4. Management systems
- 6.5. Choice of raw material and quality control
- 7. Bringing bioresorbable polymers to market
- 7.1. Introduction
- 7.2. Production process
- 7.3. Regulatory aspects
- 7.4. Conclusions
- 1. Introduction to bioresorbable polymers for biomedical applications
- Part Two. Synthesis and processing of bioresorbable polymeric materials for medical applications
- 8. Synthesis of bioresorbable polymers for medical applications
- 8.1. Introduction
- 8.2. Synthesis of raw materials
- 8.3. Synthesis of polymers
- 8.4. Polymer quality control
- 8.5. Degradation behavior
- 8.6. Polymer characterization
- 8.7. Novel ROP processes
- 8.8. Conclusions
- 9. Processing and production of bioresorbable polymer scaffolds for tissue engineering
- 9.1. Introduction
- 9.2. Scaffold fabrication
- 9.3. Conclusions and Future Directions
- 10. Synthesis and processing of hydrogels for medical applications
- 10.1. Introduction
- 10.2. Network structure and fundamental parameters
- 10.3. Hydrogel design features
- 10.4. Swelling behavior
- 10.5. Diffusion
- 10.6. Gelation
- 10.7. Physical cross-links
- 10.8. Chemical cross-links
- 10.9. Degradation
- 10.10. Degradation mechanisms
- 11. Bioresorbable polymer microparticles in the medical and pharmaceutical fields
- 11.1. Introduction
- 11.2. Types of bioresorbable polymers used for microparticles
- 11.3. Methods to prepare bioresorbable polymer microparticles
- 11.4. Important properties of bioresorbable polymer microparticles
- 11.5. Methods of application
- 11.6. Medical and pharmaceutical applications of bioresorbable polymer microparticles
- 11.7. Conclusions
- 12. Bioresorbable polymer nanoparticles in the medical and pharmaceutical fields: A promising field
- 12.1. Introduction
- 12.2. Bioresorbable polymer materials
- 12.3. Synthesis of polymer nanoparticles
- 12.4. Applications of bioresorbable polymer nanoparticles in medical and pharmaceutical fields
- 12.5. Use of nanoparticles: hurdles
- 13. Improving the pharmacodynamic and pharmacological profile of bioactive molecules using biopolymers
- 13.1. Introduction to pharmacodynamics of bioactive molecules
- 13.2. Nanobiomaterials as a promising delivery tool
- 13.3. General consideration on delivery strategy in the nervous system
- 13.4. Conclusions
- 14. Click chemistry for improving properties of bioresorbable polymers for medical applications
- 14.1. Introduction
- 14.2. Functionalization strategies
- 14.3. Case study 1: RGD peptide functionalization to improve cell adhesion
- 14.4. Case study 2: tunable drug delivery from injectable polymeric networks
- 14.5. Case study 3: in vivo tracking of degradation using noninvasive fluorescence imaging
- 14.6. Conclusions and future trends
- 15. Bioresorbable polymers for bioprinting applications
- 15.1. Introduction
- 15.2. Bioprinting platforms
- 15.3. Features of printable polymers
- 15.4. Examples of bioprinted tissues with various bioinks
- 15.5. Future perspective and discussion
- 8. Synthesis of bioresorbable polymers for medical applications
- Part Three. Clinical and research and development (R&D) applications of bioresorbable polymers
- 16. Cell delivery for regenerative medicine by using bioresorbable polymers
- 16.1. Introduction: cell delivery and regenerative medicine
- 16.2. Advantages of using a vehicle for cell delivery
- 16.3. Bioresorbable scaffolds for cell delivery: the tissue engineering approach
- 16.4. Design of bioresorbable constructs for cell delivery and tissue regeneration
- 16.5. Regulatory and clinical aspects in designing bioresorbable polymers for cell delivery
- 16.6. Challenges and future perspectives
- 17. Applications of bioresorbable polymers in the skeletal systems (cartilages, tendons, bones)
- 17.1. Introduction
- 17.2. Cartilages
- 17.3. Ligaments and tendons
- 17.4. Bones
- 17.5. Conclusions and future perspectives
- 18. Applications of bioresorbable polymers in skin and eardrum
- 18.1. Introduction
- 18.2. Skin
- 18.3. Tympanic membrane
- 18.4. Conclusions
- 19. Bioresorbable polymers for next-generation cardiac scaffolds
- 19.1. Introduction
- 19.2. Bioresorbable polymers for cardiac repair after MI
- 19.3. Bioresorbable drug delivery systems for myocardial tissue engineering
- 19.4. Conclusions and future prospects
- 20. Application of bioresorbable polymers in muscular system
- 20.1. Skeletal muscle tissue
- 20.2. Tissue engineering of muscle
- 20.3. Conclusions
- 21. Ocular applications of bioresorbable polymers—from basic research to clinical trials
- 21.1. Introduction
- 21.2. Anatomy of the eye
- 21.3. Bioresorbable polymeric drug delivery systems to the eye
- 21.4. Bioresorbable polymers for the treatment of corneal blindness
- 21.5. Vitreous substitutes
- 21.6. Retinal implants
- 21.7. Optic nerve
- 21.8. Conclusions
- 22. Applications of bioresorbable polymers in the central nervous system
- 22.1. Pathophysiology and treatment strategies
- 22.2. Spinal cord injuries and treatment strategies
- 22.3. Therapeutic potential of biomaterials
- 22.4. Biomaterials in clinical research
- 22.5. Conclusions
- 23. Engineering airways
- 23.1. Introduction
- 23.2. Anatomical overview of the airways: structure and histology
- 23.3. Tissue engineering of airway epithelium
- 23.4. Tissue engineering of trachea
- 23.5. Conclusions
- 16. Cell delivery for regenerative medicine by using bioresorbable polymers
- Conclusions
- Index
- Edition: 1
- Published: August 24, 2016
- No. of pages (Hardback): 628
- No. of pages (eBook): 628
- Imprint: Woodhead Publishing
- Language: English
- Hardback ISBN: 9780081002629
- eBook ISBN: 9780081002667
GP
Giuseppe Perale
JH