Biomedical Engineering of Pancreatic, Pulmonary, and Renal Systems, and Applications to Medicine
- 1st Edition - May 15, 2023
- Author: Dhanjoo N. Ghista
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 8 8 4 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 8 8 5 - 1
Biomedical Engineering Modeling of Pancreatic, Respiratory, and Renal Regulatory Systems, and their Medical Assessments addresses the need for biomedical engineering to provid… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteBiomedical Engineering Modeling of Pancreatic, Respiratory, and Renal Regulatory Systems, and their Medical Assessments addresses the need for biomedical engineering to provide physiological analysis of organ systems and their medical applications to help enable quantitative formulation of physiological systems and defining their functions and dysfunctions, leading to precision diagnostics of diabetes, lung diseases, and kidney failure, often in the form of non-dimensional indices. The book chapters also deal with treatment systems, namely automated insulin infusion systems, hemodialysis, and peritoneal dialysis. The book is formulated to solve many physiological, bioengineering, and medical problems.
- Covers foundational concepts of the emerging fields of quantitative physiology and computational medicine, developing the biomedical engineering modeling of three important organ systems: pancreas, lungs, and kidneys
- Provides readers with detailed understanding of novel biomedical engineering strategies in key areas, such as pancreatic system engineering, glucose-insulin regulatory system engineering, pulmonary system engineering, and renal system engineering
- Provides in-depth technical coverage of computational modeling techniques and applied mathematics for these important physiological systems, including differential equations and the associated MATLAB datasets for all applied diagnostic and treatment examples
Researchers, clinicians, developers, and industry professionals in Biomedical Engineering. Biomedical Engineers in both industry and academia as well as clinicians, and students
- Cover Image
- Title Page
- Copyright
- Table of Contents
- Contributors
- Author
- Preface
- Acknowledgments
- Introduction
- Section I Pancreatic and Glucose-Insulin Regulatory System Engineering and Medical Assessment
- Chapter 1 Pancreatic Regulatory Physiology and Medical Assessment
- Chapter Outline
- Abstract
- 1.1 Pancreatic regulatory physiology
- 1.2 Medical assessment of pancreatic function
- 1.3 Oral glucose tolerance test mathematical modeling to detect diabetic subjects
- References
- Chapter 2 Glucose-Insulin Regulatory Kinetics
- Chapter Outline
- Abstract
- 2.1 Background and motivation for this project
- 2.2 Literature review
- 2.3 Our work: the oral glucose tolerance testing protocol: adopted for classification of subjects to be normal or diabetic
- 2.4 Our work on systems engineering analysis of OGTT blood glucose and insulin response
- 2.5 Clinical applications of the model
- 2.6 Combined nondimensional physiological index (DNDI) representing both glucose and insulin model responses
- 2.7 Conclusion
- Appendix A: Solution of Equation (2.20), as given by Equations (2.21), (2.22) and (2.23)
- Appendix B: Solution of Equation (2.24), as given by Equation (2.25)
- Appendix C: Solution of Equation (2.26), as given by Equation (2.27)
- Appendix D: Solution of Equation (2.28), as given by Equation (2.29)
- Appendix E: Results of our works on classifications of subjects versus diagnosis by clinicians
- References
- Chapter 3 Automated Insulin Infusion Regulatory System
- Chapter Outline
- Abstract
- 3.1 Motivation behind the project
- 3.2 Functions of the pancreas
- 3.3 Literature review (glucose measurement)
- 3.4 Overview of current diabetes treatment and monitoring methods
- 3.5 Noninvasive insulin delivery system
- 3.6 Our work on the Automated Artificial Pancreas system
- 3.7 Control system for Insulin Infusion
- 3.8 Our work on Controller Type Selection
- 3.9 Derivation of Insulin Response in the Blood Pool
- 3.10 Simulated results of the Insulin Infusion System and its Blood Glucose Response
- 3.11 Conclusion
- Appendix A
- Appendix B
- References
- Chapter 4 Using Diabetes Technology to Maximize Diabetes Management
- Chapter Outline
- Abstract
- 4.1 Introduction
- 4.2 Continuous glucose monitoring systems
- 4.3 Smart insulin pens
- 4.4 What is a smart insulin pen?
- 4.5 Insulin pumps
- 4.6 Diabetes digital data management and support
- 4.7 Clinical case: a patient using diabetes technology to maximize diabetes management
- 4.8 Discussion: the take-home messages
- 4.9 Conclusion: the overall impression
- References
- Section II Respiratory and Pulmonary System Engineering and Medical Assessment
- Chapter 5 Physiologic and Medical Assessments of Respiratory Mechanics and Ventilation
- Chapter Outline
- Abstract
- Nomenclature
- 5.1 Introduction
- 5.2 Inverse modeling of respiratory mechanics
- 5.3 Forward modeling of respiratory mechanics
- 5.4 Conclusion
- References
- Chapter 6 Lung Ventilation Modeling and Medical Assessment
- Chapter Outline
- Abstract
- 6.1 Motivation behind the project
- 6.2 Pulmonary system
- 6.3 Literature review
- 6.4 Work of breathing
- 6.5 Model of diseased lung
- 6.6 Ventilation distribution model with nonlinear components
- 6.7 Our lung ventilation model
- 6.8 Ventilatory index
- 6.9 Variations in R and C during a respiratory cycle (towards nonlinear formats of C and R)
- 6.10 Work of breathing (WOB)
- 6.11 For noninvasive assessment of lung status, and determination of lung compliance and resistance-to-airflow
- 6.12 Two-compartmental first-order ventilatory model
- 6.13 Conclusion
- Appendix A
- Appendix B
- References
- Chapter 7 Respiratory Control Mechanism-Modeling
- Chapter Outline
- Abstract
- 7.1 Objectives
- 7.2 Introduction
- 7.3 Principal components of the respiratory process control system
- 7.4 Respiratory process control model: important variables employed
- 7.5 MATLAB-Simulink model
- 7.6 Case study: coronavirus effects in respiratory system
- 7.7 Summary
- References
- Chapter 8 Lung Alveoli and Pulmonary Capillary Gas Transfer Analysis
- Chapter Outline
- Abstract
- 8.1 Objectives
- 8.2 Respiratory system
- 8.3 Lung air composition analysis (and O2 consumption and CO2 production rates)
- 8.4 Lung gas-exchange model and parametric analysis
- 8.5 Sequential procedure to compute the diffusion coefficients DO2 and DCO2
- 8.6 Case studies to demonstrate evaluation of the diffusion coefficients
- 8.7 Nondimensional gas-transfer index (NDGTI)
- 8.8 Conclusion
- References
- Section III Renal System Engineering and Medical Assessment
- Chapter 9 Renal Physiology Theory and Functional Assessment
- Chapter Outline
- Learning objectives
- Abstract
- 9.1 Introduction
- 9.2 Functions of the kidney
- 9.3 Physiological anatomy of the kidneys
- 9.4 Mechanism of urine formation
- 9.5 Electrolyte balance
- 9.6 Acid base balance
- 9.7 Role of the kidneys in formation of EPO
- 9.8 Blood pressure regulation
- 9.9 Endocrine regulation of kidney function
- 9.10 Kidney function tests
- 9.11 Chronic kidney disease overview
- 9.12 Acute kidney injury (AKI) overview
- Bibliography
- Chapter 10 Determining Kidney Obstructions by Renogram Data Modeling
- Chapter Outline
- Abstract
- 10.1 Radionuclide renal scan for split renal function
- 10.2 Evaluation of renal function by radionuclide methods
- 10.3 Diagnostic methods
- 10.4 Clinical applications
- 10.5 Renography
- 10.6 Scintigraphic procedure
- 10.7 Processing and analysis of the study
- 10.8 Literature review on measurement of glomerular filtration rates
- 10.9 Renography modeling
- References
- Chapter 11 Artificial Kidney Function and Dialysis Physiology: Mechanisms and Analysis of Hemodialysis and Peritoneal Dialysis
- Chapter Outline
- Abstract
- Learning Objectives
- 11.1 Introduction
- 11.2 Artificial kidney function, by dialysis machine and dialyser filter
- 11.3 Hemodialysis
- 11.4 Example of an appropriate dialysis prescription for a chronic maintenance dialysis patient
- 11.5 Peritoneal dialysis
- Bibliography
- Chapter 12 Renal Physiology Modeling, Part 1: Acid Base Balance, Part 2: Body Fluid Balance
- Chapter Outline
- Abstract
- 12.1 Objectives
- 12.2 Introduction
- 12.3 Regulatory biological/physiological control system
- 12.4 Kidney, the actuator
- 12.5 Renal physiology modeling part 1: acid–base balance
- 12.6 Renal physiology modeling part 2: body fluid balance
- 12.7 Summary of the chapter
- References
- Index
- No. of pages: 754
- Language: English
- Edition: 1
- Published: May 15, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323958844
- eBook ISBN: 9780323958851
DG
Dhanjoo N. Ghista
Dr. Dhanjoo N. Ghista is President of the University 2020 Foundation and a world authority in Biomedical Engineering. Dr. Ghista is author and editor of numerous books on subjects ranging from Biomedical Engineering to Cardiology science and technology, and he is the inventor of novel medical diagnostic and surgical procedures. Dr. Ghista is a pioneer in the field of Biomedical Engineering in Translational Medicine. He promotes a new STEMbased model of Medicine for precision medicine and surgery, as well as the role of universities in contributing sustainable community development. Dr. Ghista has an international standing in academia, having set up programs and departments at universities in responsible academic-administrative positions (from Department Head to CAO/Provost), and has even been involved in planning universities. Dr. Ghista has taught courses in Engineering, Physics, Biomedical Engineering, medical sciences, sports science, and hospital management. His research involvements and publications include Biomedical Engineering, Medicine, Cognitive Science and therapy, sports science, sustainable communities, and the role of university in society. Dr. Ghista is the author/editor of Biomedical Engineering Modeling for Medical Assessment, Volumes 1-3, Springer; Coronary Artery Bypass Grafting Design Simulations, Lambert Academic Publishing; Cardiac Perfusion and Pumping Engineering, World Scientific Publishing; Applied Biomedical Engineering Mechanics, CRC Press; and Orthopaedic Mechanics Procedures and Devices, Academic Press; among many others.
Affiliations and expertise
President, University 2020 Foundation USARead Biomedical Engineering of Pancreatic, Pulmonary, and Renal Systems, and Applications to Medicine on ScienceDirect