Biomaterials for Precision Cancer Medicine

1st Edition - October 4, 2024
Imprint: Woodhead Publishing
Editors: Saeid Kargozar, Masoud Mozafari
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 6 6 1 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 5 6 7 - 6

Biomaterials for Precision Cancer Medicine bridges the gap between materials science and medicine, providing insights into novel biomaterial-based treatments for cancer. The book d… Read more

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Biomaterials for Precision Cancer Medicine bridges the gap between materials science and medicine, providing insights into novel biomaterial-based treatments for cancer. The book describes the various smart biomaterial-based treatments available, reviewing how they can be designed to target specific tumor types, adapt to changes in the cell microenvironment and offer smart, personalized therapy for different cancer variants, especially those which are drug-resistant. The book provides a materials-focused look at precision cancer medicine, and is thus useful to materials scientists, biomedical engineers, and biomedical scientists – including cancer and genetic specialists – with an interest in alternative cancer therapies.

Biomaterials for Precision Cancer Medicine
Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Foreword
Chapter 1 Introduction to biomaterials in cancer precision medicine
Abstract
Keywords
1.1 Introduction
1.2 Precision medicine: An introduction
1.3 Traditional and advanced methods of cancer management
1.4 Precision medicine in cancer modeling
1.4.1 Microfluidics
1.4.2 3D/4D Bioprinting
1.5 Precision medicine in cancer diagnosis
1.5.1 Microneedle patches
1.5.2 Targeted bioimaging
1.5.3 Cancer traps
1.6 Precision medicine in cancer treatment
1.7 Biomaterials in cancer precision medicine
1.7.1 Biomaterials for cancer modeling
1.8 Biomaterials for cancer diagnosis
1.9 Biomaterials for cancer treatment
1.9.1 Stimuli-responsive biomaterials
1.10 Conclusions
References
Chapter 2 Cancer precision medicine: Focus on gastrointestinal cancer
Abstract
Keywords
2.1 Precision medicine
2.2 Gastrointestinal (GI) cancers and current problems
2.3 Liquid biopsy
2.4 Colorectal cancer
2.4.1 Screening
2.4.2 Drug selection
2.4.3 Monitoring recurrence
2.4.4 Gene panel sequencing
2.4.5 Biomarkers
2.4.6 Precision surgery
2.5 Gastric cancer
2.5.1 Screening
2.5.2 Drug selection
2.5.3 Monitoring recurrence
2.5.4 Gene panel sequencing
2.5.5 Biomarkers
2.5.6 Precision surgery
2.6 Esophageal cancer
2.6.1 Screening
2.6.2 Drug selection
2.6.3 Monitoring recurrence
2.6.4 Gene panel sequencing
2.6.5 Biomarkers
2.6.6 Precision surgery
2.7 Pancreatic cancer
2.7.1 Screening
2.7.2 Drug selection
2.7.3 Monitoring recurrence
2.7.4 Gene panel sequencing
2.7.5 Biomarkers
2.7.6 Precision surgery
2.8 Liver cancer
2.8.1 Screening
2.8.2 Drug selection
2.8.3 Monitoring recurrence
2.8.4 Gene panel sequencing
2.8.5 Biomarkers
2.8.6 Precision surgery
2.9 Future perspective
Funding
Disclosures
References
Chapter 3 Anticancer biomaterials: A special design for precision medicine
Abstract
Keywords
3.1 Introduction
3.2 Precision medicine: A brief introduction
3.3 Biocompatible materials: Beneficial tools in biomedicine
3.4 Biomaterials for cancer precision medicine
3.4.1 Precision biomaterials for cancer diagnosis
3.4.2 Precision biomaterials for cancer treatment
3.5 Concluding remarks
References
Chapter 4 Nanosized metals and their compounds for cancer photothermal therapy
Abstract
Keywords
4.1 Introduction
4.2 Phototherapy
4.3 Phototherapy in oncology
4.3.1 Photothermal therapy (PTT)
4.3.2 Photothermal agents
4.4 PTT-based combination therapy of cancer using metal NPs
4.5 Conclusion
Declaration of AI-assisted technologies in the writing process
References
Chapter 5 Natural polymers for diagnosis and treatment of cancers
Abstract
Keywords
5.1 Introduction
5.2 Natural polymers
5.3 Natural polymers for cancer diagnosis
5.3.1 Polymeric carriers for diagnosis materials encapsulation
5.3.2 Polymer-coated magnetic nanoparticles for cancer diagnosis
5.4 Natural polymers for cancer therapy
5.4.1 Chitosan as an anticancer drug delivery system
5.4.2 Alginate hydrogels application in cancer therapy
5.4.3 Collagen application in cancer therapy
5.4.4 Hyaluronic acid application in cancer therapy
5.5 Conclusion
References
Chapter 6 Synthetic polymers for malignancies treatment
Abstract
Keywords
6.1 Introduction
6.2 Synthetic polymers as an anticancer drug carrier
6.2.1 Applications of synthetic polymers in drug delivery
6.3 Drug-polymer conjugates
6.3.1 PEGylation of protein
6.4 Polymeric nanoparticles (PNP) for anticancer drug delivery
6.4.1 PLGA
6.4.2 Cyclodextrins (CDs)
6.5 Synthetic polymers for targeting drug delivery
6.6 Conclusion
References
Chapter 7 Hydroxyapatite (HAp) nanoparticles: Promises in cancer diagnosis and therapy
Abstract
Keywords
7.1 Introduction
7.2 Synthesis and modification methods of hap particles
7.3 Cancer: What do we know and what should we do?
7.4 Interaction of HAp nanoparticles with tumor cells
7.5 Ion-doped HAp in cancer therapy
7.6 HAp for anticancer drug delivery
7.7 Surface-modified HAp for targeted therapy
7.8 HAp nanoparticles for cancer imaging
7.9 Concluding remarks
References
Chapter 8 Bioactive magnetic glass–ceramics for cancer treatment
Abstract
Keywords
8.1 Introduction
8.2 Magnetic hyperthermia
8.3 Magnetic and bioactive glass–ceramics for tumors treatment
8.3.1 Glass-ceramics via melt and quenching method
8.3.2 Glass–ceramics via sol–gel route
8.4 Innovative magnetic and bioactive glass–ceramics
8.5 Conclusions, challenges, and future perspectives
References
Chapter 9 Engineering precision mesoporous bioactive glass nanospheres toward precision cancer nanotheranostics
Abstract
Keywords
9.1 Introduction
9.2 Precision biomaterials for precision cancer therapy
9.3 Toward precision mesoporous bioactive glass nanospheres
9.3.1 Tunable composition, particle size, surface area, and mesoporosity
9.3.2 Tunable surface chemistry for precision targeting of cancer cells
9.4 Engineering precision mesoporous bioactive glass nanospheres for precision cancer therapy
9.4.1 Precision mesoporous bioactive glass nanospheres for precision cancer biomarkers detection
9.4.2 Precision mesoporous bioactive glass nanospheres for precision cancer imaging and precision cancer phototherapy/catalytic therapy
9.4.3 Precision mesoporous bioactive glass nanospheres for precision cancer imaging, precision cancer chemotherapy, and tissue regeneration
9.5 Conclusions
References
Chapter 10 Versatile applications of carbon nanostructures in cancer diagnosis and therapy
Abstract
Keywords
10.1 Introduction
10.2 Carbon nanomaterials for delivery of anticancer drugs
10.2.1 Graphene
10.2.2 Carbon nanotubes (CNTs)
10.2.3 Fullerenes
10.2.4 Carbon quantum dots (CQDs)
10.2.5 Nanodiamonds (NDs)
10.3 Cancer diagnosis
10.3.1 Imaging
10.4 Cancer biosensors
10.5 Conclusions
References
Chapter 11 Biofunctionalization of materials for targeting cancer cells
Abstract
Keywords
11.1 Introduction
11.2 Type of targeting ligand
11.2.1 Folate
11.2.2 Peptides
11.2.3 Hyaluronic acid
11.2.4 Aptamers
11.3 Functionalization of inorganic materials
11.3.1 Magnetic nanoparticles
11.3.2 Iron oxide nanoparticles
11.3.3 Gold
11.3.4 Carbon
11.3.5 Graphene
11.3.6 Carbon nanotubes
11.3.7 Titanium dioxide nanoparticles
11.3.8 Silica
11.4 Functionalization of organic materials
11.4.1 Liposomes
11.4.2 Micelles
11.4.3 MOFs
11.4.4 Dendrimers
11.4.5 Quantum dot
11.4.6 Organic nanoparticles applied for PDT
11.4.7 Natural polymeric nanoparticles
11.5 Conclusion
References
Chapter 12 Advances in engineered smart biomaterials for cancer immunotherapy
Abstract
Keywords
12.1 Introduction
12.2 Polymeric-based smart biomaterials
12.2.1 Hydrogels
12.2.2 Liposomes
12.2.3 Micelles
12.2.4 Nanoparticulate systems
12.3 Inorganic-based smart biomaterials
12.3.1 Silicate nanoparticles
12.3.2 Iron oxide nanoparticles
12.3.3 Gold nanoparticles
12.4 Engineered smart biomaterials for immunotherapy delivery
12.5 Concluding remarks and perspectives
References
Chapter 13 Advanced biomaterials and scaffolds for cancer immunotherapy
Abstract
Keywords
13.1 Introduction
13.2 Cancer immunotherapy approaches
13.2.1 Antibody-based immunotherapy
13.2.2 Cell-based immunotherapy
13.2.3 Immunomodulatory therapies
13.2.4 Immuno-gene therapy
13.2.5 Cancer vaccines
13.3 Biomaterials for cancer immunotherapy
13.3.1 Organic materials
13.3.2 Inorganic biomaterials
13.4 Three-dimensional (3D) scaffolds for immunotherapy
13.4.1 Implantable scaffolds
13.4.2 Injectable scaffolds
13.4.3 Transdermal constructs
13.5 Conclusions
References
Chapter 14 Smart nanocarriers for overcoming platinum resistance in cancer: A mechanistic view
Abstract
Keywords
Acknowledgment
14.1 Introduction
14.2 Platinum-containing drugs in cancer
14.2.1 Mechanisms of action of platinum anticancer drugs
14.3 Platinum drug delivery using nanocarriers
14.3.1 Liposomes in platinum drug delivery
14.3.2 Polymers in platinum drug delivery
14.3.3 Dendrimers in platinum drug delivery
14.3.4 Inorganic nanoparticles in platinum delivery
14.4 Mechanisms of NPs in overcoming drug resistance
14.4.1 Alteration in cellular uptake pathways
14.4.2 Combination with other chemotherapeutics drugs
14.4.3 Combination with inhibitors
14.4.4 Combination with gene therapy
14.4.5 Other combinational therapy
14.5 Conclusion and future perspectives
Conflict-of-interest
References
Chapter 15 Cancer diagnosis and therapy by electrospun nanofibers: Opportunities and challenges
Abstract
Keywords
15.1 Introduction
15.2 Cancer: An unsolved problem
15.3 An overview of electrospinning technique
15.4 Emerging roles of electrospun nanofibers in cancer research
15.4.1 Drug delivery
15.4.2 Stimuli-responsive nanofibers
15.4.3 Cancer cell detection/biosensing
15.4.4 Circulating tumor cells capture/isolation
15.4.5 Cancer theranostic applications
15.4.6 Nanofibers for adjusting cancer cell behavior
15.4.7 Nanofibers for engineering in vitro 3D cancer models
15.5 Concluding remarks
References
Chapter 16 Multiparametric preclinical assessment of cancer theranostic nanomaterials
Abstract
Keywords
16.1 Introduction
16.2 Medical devices
16.3 Diagnostic tools and devices
16.4 Nanomaterials
16.4.1 Size
16.4.2 Morphology
16.4.3 Composition
16.5 Theranostic nanomaterials
16.5.1 Theranostics nanomaterials in cancer research
16.6 Preclinical assessments of theranostic nanomaterials
16.6.1 Structural characterization and quality properties
16.6.2 Functional assessments
16.6.3 Stability evaluations
16.6.4 Biological evaluations
16.6.5 Absorption, distribution, metabolism, and excretion (ADME) considerations
16.6.6 Dosimetry
16.7 Concluding remarks and future outlook
References
Chapter 17 Future perspectives and challenges for biomaterials in cancer precision medicine
Abstract
Keywords
17.1 Introduction
17.2 Metallic ions and nanoparticles for cancer therapy
17.3 Macromolecules and polymeric biomaterials for cancer therapy
17.4 Glasses and glass-ceramics and a game changer in cancer therapy
17.5 Future perspectives and remaining challenges
References
Index

Saeid Kargozar

Saeid Kargozar is a Fellow of the University of Texas Southwestern Medical Center (UTSW), USA. He was previously a Senior Assistant Professor of Tissue Engineering in the Department of Anatomy and Cell Biology, at Mashhad University of Medical Sciences in Iran. He received his M.S. in Medical Biotechnology in 2012 and his Ph.D. in Tissue Engineering in 2016, both from Tehran University of Medical Sciences, Iran. His current research interests include biocompatible materials and tissue engineering with special focus on bioactive glasses and the decellularized extracellular matrix (ECM). He is an active member of the American Ceramic Society and has published more than 118 peer-reviewed publications. According to a recent scientometric study published in PLOS Biology in 2021, he is listed amongst the top 2% of cited scientists in the world.

Affiliations and expertise

UT Southwestern Medical Center

Masoud Mozafari

Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafari’s research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.

Affiliations and expertise

Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health