Biomaterials and Stem Cell Therapies for Biomedical Applications
- 1st Edition - June 7, 2024
- Imprint: Woodhead Publishing
- Editors: Deepti Singh, Pierre C. Dromel, Daniel J. Thomas
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 0 8 5 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 0 8 6 - 5
Biomaterials and Stem Cell Therapies for Biomedical Applications discusses the current research concepts and emerging technologies in the fields of biomaterials and tissue engine… Read more
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Request a sales quoteBiomaterials and Stem Cell Therapies for Biomedical Applications discusses the current research concepts and emerging technologies in the fields of biomaterials and tissue engineering. Divided into four distinct sections, the book explores these state-of-the art technologies, opening with a description of stem cell technologies for biomedical applications before exploring biomaterials for biomedical applications, combinational approaches using stem cells and biomaterials, and finally, nanomedicine approaches for tissue regeneration. Topics include wound healing, tissue engineering, regenerative biomaterials, and stem cell treatments for wound healing and tissue regeneration. This concise and informative volume presents the latest developments in a highly informative and easy-to-read style.
- Covers a range of tissue types, such as neural and cardiovascular, as well as various biomaterials and scaffolds to help the reader match the most appropriate material/technique to the target tissue
- Provides the necessary background, definitions and applications of soft tissue regeneration, stem cell technologies, nanomaterials, biomaterials, and scaffolds in specific biomedical settings
- Brings together multiple disciplines with chapters written by leading scientists, engineers, and clinicians to explore vital new areas of research
Researchers working in biomaterials, biotechnology and regenerative medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Introduction
- Section 1: Stem cell technologies in regenerative medicine
- Chapter 1. Stem cell emergency care 3D bioprinting
- Abstract
- 1.1 Introduction
- 1.2 Types of stem cells used in emergency care
- 1.3 3D printing techniques for scaffold fabrication
- 1.4 Applications of stem cells and 3D printing in burn treatment
- 1.5 Regulatory consideration
- 1.6 Conclusion
- Acknowledgments
- References
- Chapter 2. Sol–gel-based cellular materials for medical applications
- Abstract
- 2.1 Introduction to sol–gel processing
- 2.2 Properties of sol–gel-based cellular materials
- 2.3 Synthesis of sol–gel-based cellular materials
- 2.4 Applications in tissue engineering
- 2.5 Drug delivery applications
- 2.6 Applications in wound healing
- 2.7 Conclusion and future directions
- References
- Chapter 3. Scaffold-based stem cells tissue graft
- Abstract
- 3.1 Introduction
- 3.2 Types of scaffold materials
- 3.3 Stem cell types
- 3.4 Scaffold fabrication techniques
- 3.5 Scaffold surface modification
- 3.6 Scaffold characterization
- 3.7 Applications in tissue engineering
- 3.8 In vivo studies
- 3.9 Conclusion and future directions
- References
- Chapter 4. Stem cells for emergency wound healing
- Abstract
- 4.1 Introduction
- 4.2 Basics of wound healing
- 4.3 Stem cells and their therapeutic potential
- 4.4 Stem cell-based therapies for wound healing
- 4.5 Stem cell-based therapies in emergency wound healing
- 4.6 Conclusion
- References
- Section 2: Biomaterials for regenerative medicine
- Chapter 5. Drug delivery for central nervous system injury
- Abstract
- 5.1 Introduction
- 5.2 Drug action and neurotransmitters
- 5.3 Dysfunctions and disorders
- 5.4 CNS diseases and their causes
- 5.5 Drug for CNS
- 5.6 Discovery and development
- 5.7 Fluoxetine (Prozac) for depression
- 5.8 Clozapine for schizophrenia
- 5.9 Modafinil for narcolepsy
- 5.10 Riluzole for amyotrophic lateral sclerosis
- 5.11 Novel drug delivery system for CNS
- 5.12 Preclinical nanoparticle research
- 5.13 Clinical trials
- 5.14 Concept and mechanism
- 5.15 Advantages of cell-based drug delivery
- 5.16 Types of cells used
- 5.17 Conclusion
- Acknowledgments
- References
- Chapter 6. Stem cell cultures and injections for nerve damage
- Abstract
- 6.1 Introduction
- 6.2 Cranial nerves
- 6.3 Spinal nerves
- 6.4 Concluding remarks
- References
- Chapter 7. Biomaterial for treating hemorrhagic stroke
- Abstract
- 7.1 Introduction
- 7.2 Biomaterials for hemorrhage control and hemostasis
- 7.3 Engineering injectable hydrogels
- 7.4 Incorporating thrombin
- 7.5 Tranexamic acid
- 7.6 Multiple hemostatic mechanisms
- 7.7 Functionalizing with cell adhesion motifs from ECM proteins
- 7.8 Hydrogel depots for sustained drug release
- 7.9 Nanoparticle drug carriers (liposomes, micelles, dendrimers)
- 7.10 Biomimetic materials and scaffolds for axonal regrowth
- 7.11 Applications in axonal regrowth
- 7.12 Future directions for translating hemorrhagic stroke biomaterials
- Acknowledgments
- References
- Chapter 8. Biomaterials-based stem cell therapies for critical retinal regeneration
- Abstract
- 8.1 Introduction
- 8.2 Natural biomaterials for tissue engineering the retina
- 8.3 Protein-based biomaterials
- 8.4 Fibrin
- 8.5 Silk
- 8.6 Gelatin
- 8.7 Polysaccharide-based biomaterials
- 8.8 Alginate
- 8.9 Cellulose
- 8.10 Agar and agarose
- 8.11 Glycosaminoglycans-derived biomaterials
- 8.12 Hyaluronic acid
- 8.13 Chondroitin sulfate
- 8.14 Chitin or chitosan
- 8.15 Decellularized extracellular matrices
- 8.16 Synthetic biomaterials
- 8.17 Composite biomaterials
- 8.18 Nanomaterials
- 8.19 Conclusion
- References
- Chapter 9. Advanced treatments for autoimmune diseases
- Abstract
- 9.1 Introduction
- 9.2 Current treatment modalities and drug therapies
- 9.3 Multiple sclerosis: an overview
- 9.4 Stem cell therapies for multiple sclerosis
- 9.5 Parkinson’s disease overview
- 9.6 Stem cell research
- 9.7 Rheumatoid arthritis overview
- 9.8 Conclusion
- Acknowledgments
- References
- Section 3: Healthcare applications of regenerative medicine
- Chapter 10. Biomaterials and stem cells for cardiac dysfunction treatments
- Abstract
- 10.1 Introduction
- 10.2 Cardiac patch
- 10.3 3D printing of cardiac progenitor cells
- 10.4 Functional maturation of human-induced pluripotent stem cell-derived cardiomyocytes
- 10.5 Use of small intestine submucosal extracellular matrix in cardiovascular applications: a detailed overview
- 10.6 Conclusion
- Acknowledgments
- References
- Chapter 11. Biomaterial based treatment strategies for lung and respiratory diseases
- Abstract
- 11.1 Introduction
- 11.2 Biomaterials
- 11.3 Lung decellularization for development of bioartificial lung
- 11.4 Additive manufacturing using biomaterials
- 11.5 Conclusion
- References
- Chapter 12. Cartilage regeneration from injectable biomaterials
- Abstract
- 12.1 Introduction
- 12.2 Polymers
- 12.3 Cross-linking of polymers
- 12.4 Types of hydrogels
- 12.5 Types of cells
- 12.6 Clinical trials
- 12.7 Conclusion
- Acknowledgments
- References
- Chapter 13. Cell-seeded scaffold for bone tissue engineering
- Abstract
- 13.1 Introduction to bone tissue engineering and the need for scaffold-based approaches
- 13.2 Types of scaffold materials
- 13.3 Properties of an ideal scaffold for bone tissue engineering
- 13.4 Cell sources for bone tissue engineering
- 13.5 Scaffold seeding techniques
- 13.6 Cell–scaffold interactions
- 13.7 In vitro and in vivo evaluation of cell-seeded scaffolds
- 13.8 Clinical applications of cell-seeded scaffolds for bone tissue engineering
- 13.9 Future directions and challenges
- References
- Chapter 14. Facial reconstruction using nondegradable biomaterials
- Abstract
- 14.1 Introduction
- 14.2 Nondegradable biomaterials for facial reconstruction
- 14.3 Biocompatibility of nondegradable biomaterials
- 14.4 Preoperative planning for facial reconstruction
- 14.5 Surgical techniques for facial reconstruction
- 14.6 Postoperative care
- 14.7 Future directions
- References
- Chapter 15. Clinical trials
- Abstract
- 15.1 Introduction
- 15.2 Types of clinical trials
- 15.3 Designing a clinical trial
- 15.4 Conducting a clinical trial
- 15.5 Analyzing and interpreting trial results
- 15.6 Regulatory considerations
- 15.7 Challenges and future directions
- 15.8 Conclusion
- References
- Section 4: Nanomedicine approaches in regenerative medicine
- Chapter 16. Nanomedicine approaches for regenerative medicine
- Abstract
- 16.1 Introduction
- 16.2 Types of nanomaterials for regenerative medicine
- 16.3 Functionalization of nanomaterials for regenerative medicine
- 16.4 Nanomaterials as scaffolds for tissue engineering
- 16.5 Nanomedicine for advanced therapy delivery
- 16.6 Conclusion
- References
- Chapter 17. Regenerative nanomaterials
- Abstract
- 17.1 Introduction
- 17.2 Types of regenerative nanomaterials
- 17.3 Functionalization of regenerative nanomaterials
- 17.4 Regenerative nanomaterials as scaffolds for tissue engineering
- 17.5 Advanced therapy delivery with regenerative nanomaterials
- 17.6 Clinical applications of regenerative nanomaterials
- 17.7 Conclusions
- References
- Chapter 18. Nanomaterials for wound healing
- Abstract
- 18.1 Introduction
- 18.2 Types of nanomaterials for wound healing
- 18.3 Functionalization of nanomaterials for wound healing
- 18.4 Nanomaterials as scaffolds for tissue engineering
- 18.5 Nanomaterials for advanced wound dressings
- 18.6 Clinical applications of nanomaterials in wound healing
- 18.7 Conclusion
- References
- Chapter 19. Nanomedicine for tissue engineering
- Abstract
- 19.1 Introduction
- 19.2 Types of nanomaterials for tissue engineering
- 19.3 Functionalization of nanomaterials for tissue engineering
- 19.4 The role of nanomaterials as scaffolds for tissue engineering
- 19.5 Nanomedicine for advanced therapy delivery in tissue engineering
- 19.6 Clinical applications of nanomedicine in tissue engineering
- 19.7 Conclusion
- References
- Index
- Edition: 1
- Published: June 7, 2024
- No. of pages (Paperback): 450
- No. of pages (eBook): 600
- Imprint: Woodhead Publishing
- Language: English
- Paperback ISBN: 9780443190858
- eBook ISBN: 9780443190865
DS
Deepti Singh
Deepti Singh is a bioengneer who has been exploring the application of polymeric materials in restoring or repairing injured tissues and organs. With a Ph.D in genetics and biotechnology, she has worked extenisively for the last decade to develop functional biomimetic that can enhance differeniation of embyronic stem cells into desired linage. This book focuses on interesting and new aspects of biomaterial design and its applications. With the emergence of bio-ink, 3D printing could potentially change the entire apporach of regenerative medicine in which instead of restoring and repairing, the disease tissue can be replaced.
Affiliations and expertise
Research Fellow, Michael Young's Lab, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USAPD
Pierre C. Dromel
Pierre C Dromel (M.Sc., Ph.D.) is a bioengineer with a M.Sc. in Material Science from ENPC (France), a M.Sc. in Neurotechnology from Imperial College London and a Ph.D. from MIT on Biomaterials and stem cell therapies and currently is a Research Fellow at Schepens Eye Research Institute of Harvard Medical School. He has used his multi-disciplinary set of skills to actively participate in the discovery of novel treatments using biomaterials-based stem cell therapies for retinal regeneration. Finding new type of delivery vehicle has allowed him to proof the protection of injected cells and their engraftment enhancement.
Affiliations and expertise
Research Fellow, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USADT
Daniel J. Thomas
Dr. Daniel J. Thomas (BEng (Hons) MSc EngD CSci CEng CEnv FBCS) is an Engineer and Writer who comes from a research background in computational design, biomaterials, 3D Printing, electronics and surgery disciplines. He has Authored two previous medical books and has published 70 journal publications.
https://scholar.google.com/citations?user=OE_l9JoAAAAJ&hl=en
Affiliations and expertise
3Dynamic Systems – Llynfi Enterprise Centre, Heol Ty Gwyn, Wales, UKConsultant Engineer NASA Johnson Space Center, Houston, Texas, USARead Biomaterials and Stem Cell Therapies for Biomedical Applications on ScienceDirect