Biomarkers of Hip Implant Function
- 1st Edition - January 10, 2023
- Imprint: Academic Press
- Editor: Ilona Swiatkowska
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 9 6 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 4 2 - 9
Nearly all orthopaedic surgeons have implanted a cobalt-chromium hip, and most general practitioners have at least one patient with a cobalt-chromium prosthesis on their books. Th… Read more
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Request a sales quoteNearly all orthopaedic surgeons have implanted a cobalt-chromium hip, and most general practitioners have at least one patient with a cobalt-chromium prosthesis on their books. The recent worldwide controversy surrounding metal-on-metal bearings – and increasing concern over the use of metallic biomaterials in general – means that advice on how to manage patients with metal implants is of great interest to these professionals. Specifically, they want to know if there are any diagnostic tests that could be performed to gain clues about implant performance and the risk of local or systemic toxicity.
Biomarkers of Hip Implant Function aims to bring together all established and promising new biomarkers and critically evaluate their clinical usefulness. Researchers will benefit from an updated, comprehensive view of the topic to identify underexplored areas. Orthopaedic surgeons and general practitioners will use the book to monitor implant performance and manage their patients. The work may also benefit engineers and joint implant manufacturers by guiding improvements in implant design, and be of interest to regulators and policymakers to inform guidelines on the follow-up of hip implant recipients.
- Covers all established and candidate biomarkers of hip implant wear, periprosthetic infection, and toxicity
- Summarises recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions
- Reviews over 50 cases of suspected systemic cobalt toxicity to raise awareness of its symptoms and clinical presentation, and guide investigations and treatment decisions
Researchers with crossover for clinicians; orthopaedic surgeons and general practitioners; engineers and joint implant manufacturers; regulators and policy influencers, such as the FDA and the UK's Medicines and Healthcare products Regulatory Agency (MHRA)
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Part I: Foundational information
- Chapter 1. Introduction to hip implants and biomarker testing
- Abstract
- 1.1 Overview of the hip joint
- 1.2 Overview of hip implants
- 1.3 Introduction to biomarkers
- References
- Chapter 2. Degradation of metal hip implants
- Abstract
- 2.1 Introduction to metallic biomaterials
- 2.2 Introduction to tribology
- 2.3 Introduction to corrosion
- 2.4 Tribocorrosion
- 2.5 Modern hip replacements
- 2.6 Summary and future directions
- References
- Chapter 3. Implant metals and their potential toxicity
- Abstract
- 3.1 Hip implant metals and the human health
- 3.2 Metal hypersensitivity
- 3.3 Local effects of metal debris
- References
- Part II: Assessing hip implant function and risk of local and systemic adverse reactions
- Chapter 4. Markers of hip implant degradation: analytical considerations and clinical interpretation
- Abstract
- 4.1 Introduction
- 4.2 Mechanisms of implant degradation
- 4.3 Measuring systemic levels of cobalt, chromium, and titanium
- 4.4 Using systemic metal levels to assess implant degradation and risk of local adverse reactions
- 4.5 Summary and future directions
- References
- Chapter 5. Biomarkers of compromised implant fixation
- Abstract
- 5.1 Introduction
- 5.2 Osseointegration of hip implants
- 5.3 Periprosthetic osteolysis and aseptic loosening
- 5.4 Postoperative measures to stimulate osseointegration and inhibit osteolysis
- 5.5 Monitoring patients for signs of periprosthetic osteolysis and aseptic loosening
- 5.6 Molecular biomarkers of periprosthetic osteolysis and aseptic loosening
- 5.7 Summary and future directions
- References
- Chapter 6. Biomarkers of periprosthetic joint infection
- Abstract
- 6.1 Introduction
- 6.2 Periprosthetic joint infection
- 6.3 Clinical definition of periprosthetic joint infection
- 6.4 Diagnostic categories
- 6.5 Confounding factors
- 6.6 Summary and future directions
- References
- Chapter 7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies
- Abstract
- 7.1 Introduction
- 7.2 Arthroprosthetic cobaltism
- 7.3 Summary and future directions
- References
- Part III: Translational effect of biomarker research on clinical practice
- Chapter 8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements
- Abstract
- 8.1 Introduction
- 8.2 Evaluating implant wear and risk of local adverse reactions to metal debris in patients with metal-on-metal hips
- 8.3 Investigation for systemic toxicity
- 8.4 Monitoring of patients with titanium-based hip implants
- 8.5 Investigation for periprosthetic infection
- 8.6 Summary and future directions
- References
- Index
- Edition: 1
- Published: January 10, 2023
- No. of pages (Paperback): 292
- No. of pages (eBook): 292
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128215968
- eBook ISBN: 9780128217429
IS
Ilona Swiatkowska
Ilona Świątkowska is an experienced researcher and editor who received her doctorate from University College London. Her academic work has centred around the local and systemic adverse effects of cobalt, chromium, and titanium in the setting of hip arthroplasty. The project was supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital (Stanmore, United Kingdom), whose research into blood cobalt and chromium levels in recipients of hip replacements directly influenced the current MHRA guidelines concerning the follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined updated laboratory reference ranges for blood and plasma titanium concentrations associated with well-functioning titanium-based hip implants.
Affiliations and expertise
University College London, United KingdomRead Biomarkers of Hip Implant Function on ScienceDirect