
Biology and Engineering of Stem Cell Niches
- 1st Edition - March 22, 2017
- Imprint: Academic Press
- Editors: Ajaykumar Vishwakarma, Jeffrey M Karp
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 0 2 7 3 4 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 2 7 5 6 - 1
Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understan… Read more

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Request a sales quoteBiology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions.
The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.
A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.
- Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system
- Authored and edited by authorities in this emerging and multidisciplinary field
- Includes valuable links to 5-10 minute YouTube© author videos that describe main points
Stem cell biologist, molecular biologist, bioengineers, materials scientists, and regenerative medicine investigators working in the area of stem cell niches; undergraduate and graduate level students, trainees and researchers in biotechnology
Part I. Biology of Stem Cell Niches and Molecular Mechanisms
Chapter 1. The Need to Study, Mimic, and Target Stem Cell Niches
- 1. Introduction
- 2. Biology of the Stem Cell Niche
- 3. Biochemical and Biophysical Regulation of Stem Cell Behavior
- 4. Mimicking the Stem Cell Niche: Bioengineering Tools and Techniques
- 5. Bioengineering Specialized Artificial Stem Cell Niches for Clinical Therapies
Chapter 2. Harnessing the Biology of Stem Cells' Niche
- 1. Introduction
- 2. Components of the Stem Cell Niche
- 3. Integrative Networks Regulating the Niche
- 4. Distinct Niches for Different Stages of Differentiation
- 5. Neoplastic Transformation and Disturbance of the Tissue Ecosystem
- 6. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 3. Pluripotent Stem Cell Microenvironment
- 1. Introduction
- 2. Pluripotent Cell Microenvironment in the Early Mammalian Embryo
- 3. Microenvironment of Pluripotent Stem Cells In Vitro
- 4. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 4. Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling
- 1. Introduction
- 2. Organization of Hematopoietic Stem Cell Niche in the Bone Marrow
- 3. Niche Signaling
- 4. Future Outlook and Challenges
- Abbreviations and Acronyms
- Glossary
Chapter 5. HSC Niche: Regulation of Mobilization and Homing
- 1. Introduction
- 2. HSC Trafficking During Embryonic Development
- 3. HSC Trafficking in Adult Hematopoiesis
- 4. New Strategies to Enhance Homing and Engraftment of HSC
- 5. Techniques to Dissect the Mechanism of HPC Migration
- 6. Clinical Applications of the Mobilization Agents and Biochemical Factors
- 7. Conclusion
- Glossary
Chapter 6. Neuronal Stem Cell Niches of the Brain
- 1. Introduction
- 2. Organization of the Brain's Neuronal Stem Cell Niches
- 3. Functional Role of the Brain's Neuronal Stem Cell Niches
- 4. Signaling in the Neural Stem Cell Niche
- 5. Neural Stem Cell Niche in Aging
- 6. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 7. Cardiovascular Stem Cell Niche
- 1. Introduction
- 2. Myocyte Regeneration and Cardiac Progenitor Cell Niches
- 3. Lineage Tracing of the Stem Cell Progeny
- 4. Stem Cells: Studies at the Single-Cell Level
- 5. Cardiac Progenitor Cell Classes and Their Niches
- 6. c-kit-CPCs and Their Niches
- 7. Epicardial Progenitor Cell Niches
- 8. Mesenchymal Stem Cells and Cardiac Niches
- 9. Hypoxic Niches
- 10. Cardiomyocyte Proliferation and the Notch Receptor System
- 11. Cardiac Niches and the Notch Receptor System
- 12. Conclusions
- Abbreviations and Acronyms
- Glossary
Chapter 8. Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids
- 1. Introduction
- 2. Intestinal Stem Cell
- 3. The Stem Cell Niche
- 4. Ex Vivo Intestinal Stem Cells Culture—Organoids
- 5. Application of Organoid System
- 6. Concluding Remarks
Chapter 9. The Epithelial Stem Cell Niche in Skin
- 1. Introduction
- 2. The Adult Skin: A Model to Study Various Epithelial Stem Cells
- 3. The Multiple Actors in Adult Epithelial Stem Cell Niche in the Skin
- 4. Do the Niche Cells From Various Locations Regulate the Epithelial Stem Cell Fate Differently?
- 5. Conclusions
- Abbreviations and Acronyms
- Glossary
Chapter 10. The Satellite Cell Niche in Skeletal Muscle
- 1. Introduction
- 2. The Quiescent Satellite Cell Niche
- 3. The Activated Satellite Cell Niche
- 4. Alterations of the Satellite Cell Niche
- 5. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 11. The Cancer Stem Cell Niche
- 1. Introduction
- 2. Cancer Stem Cells and Niche Interactions
- 3. Cancer Stem Cell Niche Promotes Tumor Growth and Progression
- 4. The Role of the Cancer Stem Cell Niche in Metastasis
- 5. Therapeutic Targeting of Cancer Stem Cell Niche
- 6. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 12. Cellular Senescence and Stem Cell Niche
- 1. Introduction
- 2. Cellular Senescence
- 3. p16INK4a
- 4. Senescence-Associated Secretory Phenotype
- 5. Senescence and Tissue Repair
- 6. Stem Cell Niche
- 7. Effects of Aging and Senescence on the Stem Cell Niche
Part II. Biochemical and Physical Cues in The Stem Cell Niche Directing Cell Fate
Chapter 13. Matrix Chemistry Controlling Stem Cell Behavior
- 1. Introduction
- 2. Effect of Chemical Functional Groups on Stem Cell Behavior
- 3. Conclusions and Future Directions
- Abbreviations and Acronyms
- Glossary
Chapter 14. Matrix Growth Factor and Surface Ligand Presentation
- 1. Introduction
- 2. Modulating Factor-Mediated Signaling
- 3. Cell–Cell Ligand Presentation
- 4. Adhesion Ligand Presentation
- 5. Synergistic Interaction Between Adhesion Ligands and Soluble Factors
- 6. Outlook
- Abbreviations and Acronyms
Chapter 15. Effect of Matrix Mechanical Forces and Geometry on Stem Cell Behavior
- 1. The Mechanical Microenvironment of Stem Cells
- 2. The Influence of Mechanical Forces on Stem Cell Differentiation
- 3. The Influence of Matrix Geometry and Topography on Stem Cell Behavior
- 4. How Do Stem Cells Respond to Mechanical Stimuli?
- 5. Future Directions
- Abbreviations and Acronyms
Chapter 16. Wettability Effect on Stem Cell Behavior
- 1. Introduction
- 2. The Impact of Interfacial Wettability on Cells
- 3. The Impact of Interfacial Wettability on Stem Cells
- 4. Conclusion and Future Directions
Chapter 17. Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways
- 1. Introduction
- 2. Mimicking In Vivo Fluid Flow Environments
- 3. Fluid Flow Regulation of Stem Cell Function and Fate
- 4. Fluid Flow-Activated Mechanotransduction Pathways in Stem Cells
- 5. Conclusions
- Abbreviations and Acronyms
- Glossary
Chapter 18. Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and Applications
- 1. Physiological Relevance of Hypoxic Niche in Embryonic and Adult Stem Cells
- 2. Molecular Mechanism of Hypoxia-Mediated Cellular Response
- 3. Stem Cell Metabolic Adaptation Under Hypoxia
- 4. Influence of Hypoxia on Stem Cell Fate
- 5. Recapitulation of Hypoxia Niche In Vivo and In Vitro
- 6. Hypoxia-Preconditioning-Enhanced Therapeutic Function After Transplantation
- Abbreviations and Acronyms
Part III. Designing Smart Biomaterials to Mimic and Control Stem Cell Niche
Chapter 19. Polymer Design and Development
- 1. Introduction
- 2. Natural Polymers for 3D Stem Cell Culture
- 3. Synthetic Polymers for 3D Stem Cell Culture
- 4. Smart Polymer Systems for 3D Stem Cell Culture
- 5. Concluding Remarks
- Abbreviations and Acronyms
- Glossary
Chapter 20. Design and Development of Ceramics and Glasses
- 1. Introduction
- 2. Development of Bioceramics
- 3. Design of Bioactive Ceramics and Composites
- 4. Engineering Stem Cell Niches
- 5. Summary and Future Perspective
Chapter 21. Surface Functionalization of Biomaterials
- 1. Introduction
- 2. Surface Modifications of Biomaterials
- 3. Biological Relevance of Surface Modification for Biomaterials
- 4. Concluding Remarks
- Abbreviations and Acronyms
- Glossary
Chapter 22. Biofunctional Hydrogels for Three-Dimensional Stem Cell Culture
- 1. Introduction
- 2. Hydrogel Materials
- 3. Hydrogel Material Properties
- 4. Engineering Hydrogel Bioactivity
- 5. Technologies for Hydrogel Production and Assessment
- 6. Challenges and Future Directions
- 7. Conclusion
- Abbreviations and Acronyms
Chapter 23. Technologies to Engineer Cell Substrate Mechanics in Hydrogels
- 1. Introduction
- 2. Microenvironment and Its Stiffness
- 3. Dimensionality
- 4. The Determinants of Elastic Properties and Hydrogel Networks
- 5. ECM as a Substrate for Adhesive Cells
- 6. Hydrogels to Mimic the In Vivo Microenvironment
- 7. Natural Hydrogels
- 8. Synthetic Hydrogels
- 9. Development of Hydrogel Systems as a Scaffold for Cell-Based Therapies
- 10. Conclusion and Future Directions
- Abbreviations and Acronyms
Chapter 24. Micro- and Nanosurface Patterning Technologies
- 1. Introduction to Micro- and Nanopatterning Techniques for Cell Culture
- 2. Introduction to Fabrication Techniques for Nanotopography
- 3. Nanotopography and Its Applications
- 4. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 25. Self-Assembled Nanostructures (SANs)
- 1. Introduction
- 2. Layer-by-Layer Self-Assembly
- 3. Fabricating Free-Standing Thin Films Using Layer-by-Layer
- 4. Layer-by-Layer Coating on Graphene
- 5. Layer-by-Layer Coating of Nanoscale Liposomes
- 6. Layer-by-Layer Coating of Nanoparticles
- 7. Layer-by-Layer Coating of 3D Scaffolds
- 8. Self-Assembled Nanoparticles
- 9. Self-Assembled Nanofibers and Nanotubes
- 10. Conclusion
- Abbreviations and Acronyms
Chapter 26. Biomimetic Nanofibers as Artificial Stem Cell Niche
- 1. Introduction
- 2. Methods for Preparing Polymeric Nanofibers
- 3. Control Stem Cell Behaviors Through Biomimetic Nanofibers In Vitro
- 4. Delivery of Stem Cells With Biomimetic Nanofibers for Tissue Regeneration
- 5. Concluding Remarks
- Abbreviations and Acronyms
Part IV. Bioengineering Strategies to Model Synthetic Stem Cell Niches
Chapter 27. Employing Microfluidic Devices to Induce Concentration Gradients
- 1. Introduction
- 2. Engineering Concentration Gradients Using Microtechnology
- 3. Generating Micro-Engineered Gradients to Control Stem Cell Fate
- 4. Future Directions
- Abbreviations and Acronyms
- Glossary
Chapter 28. Engineering Niches for Embryonic and Induced Pluripotent Stem Cells
- 1. Introduction
- 2. Niches for Embryonic Stem/Induced Pluripotent Stem Cell Maintenance
- 3. Niches for Regulation of Differentiation
- 4. Conclusion and Outlook
- Abbreviations and Acronyms
- Glossary
Chapter 29. Engineering Niches for Cardiovascular Tissue Regeneration
- 1. Introduction
- 2. The Cardiac Microenvironment
- 3. Cell-Based Cardiac Regenerative Therapy
- 4. Biomaterial Engineering for Cardiac Regeneration
- 5. Types of Biomaterials and Their Applications
- 6. Biomaterial-Based Cardiovascular Devices
- 7. Future Direction for Cardiac Regeneration
- Abbreviations and Acronyms
- Glossary
Chapter 30. Engineering Niches for Blood Vessel Regeneration
- 1. Introduction
- 2. Elements for Recapitulating the Vascular Regeneration Niche In Vitro
- 3. Material Design Parameters for Controlling the Vascular Niche
- 4. Strategies in Engineering Artificial Niches for Vascular Regeneration
- 5. Inducing Vascularization Through Biomaterials
- 6. Conclusion and Future Directions
- Abbreviations and Acronyms
- Glossary
Chapter 31. Engineering Niches for Bone Tissue Regeneration
- 1. Introduction: The Native Bone Niche
- 2. Approaches to Control the Stem Cell Niche
- 3. Conclusions and Future Directions
- Abbreviations and Acronyms
- Glossary
Chapter 32. Engineering Vascular Niche for Bone Tissue Regeneration
- 1. Introduction
- 2. The Bone Tissue Engineering Paradigm: Scaffold, Cells, Bioreactor
- 3. Strategies to Promote Bone Vascularization
- 4. Harnessing the Inflammatory Response to Engineer Vascularized Bone
- 5. Endochondral Ossification and the Hematopoietic Niche
- 6. Conclusions and Future Directions
- Abbreviations and Acronyms
- Glossary
Chapter 33. Engineering Niches for Cartilage Tissue Regeneration
- 1. Introduction: The Native Cartilage Niche
- 2. Approaches for Engineering the Cartilage Niche
- 3. Conclusion and Future Directions
- Abbreviations and Acronyms
- Glossary
Chapter 34. Engineering Niches for Stem and Progenitor Cell Differentiation Into Immune Cells
- 1. Introduction
- 2. Hematopoiesis and Niche Signaling
- 3. 2D Immune Cell Culture Systems
- 4. Engineering 3D Immune Niche
- 5. Future Directions and Conclusions
- Abbreviations and Acronyms
- Glossary
Chapter 35. Engineering Niches for Skin and Wound Healing
- Chapter Outline
- 1. Introduction
- 2. The Skin Stem Cell Niche From a Wound Healing Perspective
- 3. Engineering of Skin Stem Cell Niches for Wound Healing
- 4. Specific Targets for Niche-Based Approaches in the Skin
- 5. Conclusion
- Abbreviations and Acronyms
Chapter 36. Designing Stem Cell Niche for Liver Development and Regeneration
- 1. Introduction
- 2. LPCs Fate Selection in Developing and Injured Liver
- 3. Hepatic Stem Cell Niches
- 4. Engineering Biomimetic Liver Niches
- 5. Conclusion
- Abbreviations and Acronyms
- Glossary
Chapter 37. Engineering the Niche for Intestinal Regeneration
- 1. Introduction
- 2. Overview of Intestinal Culture Models and Regenerative Medicine Approaches
- 3. Tools and Techniques for Engineering the Intestinal Stem Cell Niche
- 4. Future Directions: Engineering the Niche for Intestinal Modeling and Development of Regenerative Medicine Therapies
- 5. Conclusions
- Abbreviations and Acronyms
- Glossary
- Edition: 1
- Published: March 22, 2017
- Imprint: Academic Press
- No. of pages: 642
- Language: English
- Paperback ISBN: 9780128027349
- eBook ISBN: 9780128027561
AV
Ajaykumar Vishwakarma
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