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Biofluid Mechanics
An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation
- 2nd Edition - July 28, 2015
- Authors: David Rubenstein, Wei Yin, Mary D. Frame
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 0 9 4 4 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 1 1 6 9 - 0
Biofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation shows how fluid mechanics principles can be applied not only to blood circul… Read more
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Request a sales quoteBiofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation shows how fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement, renal transport among other specialty circulations. This new second edition increases the breadth and depth of the original by expanding chapters to cover additional biofluid mechanics principles, disease criteria, and medical management of disease, with supporting discussions of the relevance and importance of current research. Calculations related both to the disease and the material covered in the chapter are also now provided.
- Uses language and math that is appropriate and conducive for undergraduate learning, containing many worked examples and end-of-chapter problems
- Develops all engineering concepts and equations within a biological context
- Covers topics in the traditional biofluids curriculum, and addresses other systems in the body that can be described by biofluid mechanics principles
- Discusses clinical applications throughout the book, providing practical applications for the concepts discussed
- NEW: Additional worked examples with a stronger connection to relevant disease conditions and experimental techniques
- NEW: Improved pedagogy, with more end-of-chapter problems, images, tables, and headings, to better facilitate learning and comprehension of the material
Undergraduate and graduate students in biomedical engineering and mechanical engineering
- Preface
- Ancillaries
- Acknowledgments
- Part I: Fluid Mechanics Basics
- Chapter 1. Introduction
- Learning Outcomes
- 1.1 Note to Students about the Textbook
- 1.2 Biomedical Engineering
- 1.3 Scope of Fluid Mechanics
- 1.4 Scope of Biofluid Mechanics
- 1.5 Dimensions and Units
- 1.6 Salient Biofluid Mechanics Dimensionless Numbers
- Reference
- Chapter 2. Fundamentals of Fluid Mechanics
- Learning Outcomes
- 2.1 Fluid Mechanics Introduction
- 2.2 Fundamental Fluid Mechanics Equations
- 2.3 Analysis Methods
- 2.4 Fluid as a Continuum
- 2.5 Elemental Stress and Pressure
- 2.6 Kinematics: Velocity, Acceleration, Rotation, and Deformation
- 2.7 Viscosity
- 2.8 Fluid Motions
- 2.9 Two-Phase Flows
- 2.10 Changes in the Fundamental Relationships on the Microscale
- 2.11 Fluid Structure Interaction
- 2.12 Introduction to Turbulent Flows and the Relationship of Turbulence to Biological Systems
- References
- Chapter 3. Conservation Laws
- Learning Outcomes
- 3.1 Fluid Statics Equations
- 3.2 Buoyancy
- 3.3 Conservation of Mass
- 3.4 Conservation of Momentum
- 3.5 Momentum Equation with Acceleration
- 3.6 The First and Second Laws of Thermodynamics
- 3.7 The Navier–Stokes Equations
- 3.8 Bernoulli Equation
- Reference
- Chapter 1. Introduction
- Part II: Macrocirculation
- Chapter 4. The Heart
- Learning Outcomes
- 4.1 Cardiac Physiology
- 4.2 Cardiac Conduction System/Electrocardiogram
- 4.3 The Cardiac Cycle
- 4.4 Heart Motion
- 4.5 Heart Valve Function
- 4.6 Disease Conditions
- References
- Chapter 5. Blood Flow in Arteries and Veins
- Learning Outcomes
- 5.1 Arterial System Physiology
- 5.2 Venous System Physiology
- 5.3 Blood Cells and Plasma
- 5.4 Blood Rheology
- 5.5 Pressure, Flow, and Resistance: Arterial System
- 5.6 Pressure, Flow, and Resistance: Venous System
- 5.7 Windkessel Model for Blood Flow
- 5.8 Wave Propagation in Arterial Circulation
- 5.9 Flow Separation at Bifurcations and at Walls
- 5.10 Flow Through Tapering and Curved Channels
- 5.11 Pulsatile Flow and Turbulence
- 5.12 Disease Conditions
- References
- Chapter 4. The Heart
- Part III: Microcirculation
- Chapter 6. Microvascular Beds
- Learning Outcomes
- 6.1 Microcirculation Physiology
- 6.2 Endothelial Cell and Smooth Muscle Cell Physiology
- 6.3 Local Control of Blood Flow
- 6.4 Pressure Distribution Throughout the Microvascular Beds
- 6.5 Velocity Distribution Throughout the Microvascular Beds
- 6.6 Interstitial Space Pressure and Velocity
- 6.7 Hematocrit/Fahraeus–Lindquist Effect/Fahraeus Effect
- 6.8 Plug Flow in Capillaries
- 6.9 Characteristics of Two-Phase Flow
- 6.10 Interactions Between Cells and the Vessel Wall
- 6.11 Disease Conditions
- References
- Chapter 7. Mass Transport and Heat Transfer in the Microcirculation
- Learning Outcomes
- 7.1 Gas Diffusion
- 7.2 Glucose Transport
- 7.3 Vascular Permeability
- 7.4 Energy Considerations
- 7.5 Transport Through Porous Media
- 7.6 Microcirculatory Heat Transfer
- 7.7 Cell Transfer During Inflammation/White Blood Cell Rolling and Sticking
- References
- Chapter 8. The Lymphatic System
- Learning Outcomes
- 8.1 Lymphatic Physiology
- 8.2 Lymph Formation
- 8.3 Flow through the Lymphatic System
- 8.4 Disease Conditions
- References
- Chapter 6. Microvascular Beds
- Part IV: Speciality Circulations and Other Biological Flows
- Chapter 9. Flow in the Lungs
- Learning Outcomes
- 9.1 Lung Physiology
- 9.2 Elasticity of the Lung Blood Vessels and Alveoli
- 9.3 Pressure-Volume Relationship for Air Flow in the Lungs
- 9.4 Ventilation Perfusion Matching
- 9.5 Oxygen/Carbon Dioxide Diffusion
- 9.6 Oxygen/Carbon Dioxide Transport in the Blood
- 9.7 Compressible Fluid Flow
- 9.8 Disease Conditions
- References
- Chapter 10. Intraocular Fluid Flow
- Learning Outcomes
- 10.1 Eye Physiology
- 10.2 Eye Blood Supply, Circulation, and Drainage
- 10.3 Aqueous Humor Formation
- 10.4 Aquaporins
- 10.5 Flow of Aqueous Humor
- 10.6 Intraocular Pressure
- 10.7 Disease Conditions
- References
- Chapter 11. Lubrication of Joints and Transport in Bone
- Learning Outcomes
- 11.1 Skeletal Physiology
- 11.2 Bone Vascular Anatomy and Fluid Phases
- 11.3 Formation of Synovial Fluid
- 11.4 Synovial Fluid Flow
- 11.5 Mechanical Forces Within Joints
- 11.6 Transport of Molecules in Bone
- 11.7 Disease Conditions
- References
- Chapter 12. Flow Through the Kidney
- Learning Outcomes
- 12.1 Kidney Physiology
- 12.2 Distribution of Blood in the Kidney
- 12.3 Glomerular Filtration/Dynamics
- 12.4 Tubule Reabsorption/Secretion
- 12.5 Single Nephron Filtration Rate
- 12.6 Peritubular Capillary Flow
- 12.7 Sodium Balance and Transport of Important Molecules
- 12.8 Autoregulation of Kidney Blood Flow
- 12.9 Compartmental Analysis for Urine Formation
- 12.10 Extracorporeal Flows: Dialysis
- 12.11 Disease Conditions
- References
- Chapter 13. Splanchnic Circulation: Liver and Spleen
- Learning Outcomes
- 13.1 Liver and Spleen Physiology
- 13.2 Hepatic/Splenic Blood Flow
- 13.3 Hepatic/Splenic Microcirculation
- 13.4 Storage and Release of Blood in the Liver
- 13.5 Active and Passive Components of the Splanchnic Circulation
- 13.6 Innervation of the Spleen
- 13.7 Disease Conditions
- References
- Chapter 9. Flow in the Lungs
- Part V: Modeling and Experimental Techniques
- Chapter 14. In Silico Biofluid Mechanics
- Learning Outcomes
- 14.1 Computational Fluid Dynamics
- 14.2 Fluid Structure Interaction Modeling
- 14.3 Buckingham Pi Theorem and Dynamic Similarity
- 14.4 Current State of the Art for Biofluid Mechanics In Silico Research
- 14.5 Future Directions of Biofluid Mechanics In Silico Research
- References
- Chapter 15. In Vitro Biofluid Mechanics
- Learning Outcomes
- 15.1 Particle Imaging Velocimetry
- 15.2 Laser Doppler Velocimetry
- 15.3 Flow Chambers: Parallel Plate/Cone-and-Plate Viscometry
- 15.4 Current State of the Art for Biofluid Mechanics In Vitro Research
- 15.5 Future Directions of Biofluid Mechanics In Vitro Research
- References
- Chapter 16. In Vivo Biofluid Mechanics
- Learning Outcomes
- 16.1 Live Animal Preparations
- 16.2 Doppler Ultrasound
- 16.3 Phase Contrast Magnetic Resonance Imaging
- 16.4 Review of Other Techniques
- 16.5 Current State of the Art for Biofluid Mechanics In Vivo Research
- 16.6 Future Directions of Biofluid Mechanics In Vivo Research
- References
- Chapter 14. In Silico Biofluid Mechanics
- Further Readings Section
- Biomedical Engineering/Biomechanics
- Index
- No. of pages: 544
- Language: English
- Edition: 2
- Published: July 28, 2015
- Imprint: Academic Press
- Hardback ISBN: 9780128009444
- eBook ISBN: 9780128011690
DR
David Rubenstein
Dr. Rubenstein focuses on two major research areas: vascular tissue engineering and the initiation/progression of cardiovascular diseases mediated through platelet and endothelial cell interactions.
Affiliations and expertise
Associate Professor and Graduate Program Director, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY.WY
Wei Yin
Dr. Yin conducts research into coronary artery disease, specifically how altered blood flow and stress distribution affect platelet and endothelial cell behavior and lead to cardiovascular disease initiation.
Affiliations and expertise
Associate Professor and Undergraduate Program Director, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USAMF
Mary D. Frame
The focus of Dr. Frame’s research is in integrating signal transduction events with physical properties of blood flow at the microvascular level, with the long term research goal of understanding the two phase question of how solute distribution and transport are coupled in the microcirculation.
Affiliations and expertise
Professor, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA