Biochemical Actions of Hormones V4

List of Contributors

Preface

Contents of Previous Volumes

Gordon M. Tomkins (1926-1975)


1. Affinity Labeling as a Technique in Determining Hormone Mechanisms

I. Introduction

II. Fundamental Considerations

III. Steroid Binding Sites

IV. Cyclic Nucleotides

V. Protein Hormones

VI. Other Hormonal Systems

VII. Invertebrate Hormones

VIII. Plant Hormones

IX. Conclusion

References


2. Mechanism of Prostaglandin Action in Endocrine Glands

I. Introduction

II. Prostaglandins in Ovarian Function

References


3. Regulation of Protein Synthesis and Degradation in Heart and Skeletal Muscle

I. Introduction

II. Measurements of the Rate of Protein Synthesis

III. Localization of the Effects of Metabolic and Hormonal Factors to Steps in the Synthetic Pathway

IV. Measurement of Protein Degradation and Factors Affecting the Rate

V. Nutritional Factors Regulating Protein Turnover

VI. Role of Insulin in the Regulation of Protein Turnover

VII. Concluding Remarks

References


4. Hormonal Regulation of Cholesterol Synthesis

I. Introduction

II. Pancreas

III. Pituitary

IV. Thyroid

V. Adrenals

VI. Regulation by an Interplay of Hormones

VII. Regulation via Feedback Repression

VIII. Regulation of the Level of Cholesterol

IX. Regulation in Relation to Cardiovascular Disease

X. Perspective

References


5. The ß-Adrenergic Receptor and the Regulation of Circadian Rhythms in the Pineal Gland

I. Biosynthesis of Melatonin

II. Circadian Rhythms in the Pineal Gland

III. Conclusion

References


6. Cell Culture Studies of Thyrotropin-Releasing Hormone Action

I. Introduction

II. GH Cells Produce Both Growth Hormone and Prolactin

III. Are Both Prolactin and Growth Hormone Produced by a Single Cell?

IV. Biological Responses of GH Cells to TRH

V. The TRH Receptor

VI. Unitary Hypothesis of TRH Action

VII. Spare TRH Receptors—Multiple TRH Receptors

VIII. Summary

References


7. The Insulin Receptor: Properties and Regulation

I. Introduction

II. Indirect Studies

III. Early Direct Studies

IV. Properties of the Insulin Receptor

V. Regulation of Insulin Bioactivity at the Receptor Level

VI. Summary and Conclusions

References


8. Molecular Actions of Androgens

I. Introduction

II. Evidence for Selective Androgen Retention in Target Tissue

III. Cellular Localization and Multiple Forms of Androgen Receptors

IV. Structural Recognition in Androgen-Receptor Interaction

V. Transformation and Nuclear Retention of Androgen-Receptor Complex

VI. Acceptor Molecules and Receptor-Nucleoprotein Interaction

VII. Differential Action of Androgens and Universality of Receptors

VIII. Some Biodynamic Aspects of Androgen Receptors

IX. Mode of Action of Antiandrogens

X. RNA Synthesis

XI. Protein Synthesis

XII. Concluding Remarks—Interaction of Metals and Nucleotides with Steroid Receptors

References


9. Actions of Cyclic AMP and Its Relationship to Transmitter Function in Nervous Tissue

I. Introduction

II. Metabolism of Cyclic AMP and Its Regulation

III. Cytochemical Localization of Cyclic AMP

IV. Actions of Cyclic AMP

V. Conclusions

References

Index