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Bioactive Materials for Bone Regeneration
- 1st Edition - February 28, 2020
- Authors: Jiang Chang, Xingdong Zhang, Kerong Dai
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 3 5 0 3 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 3 5 0 4 - 4
Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interacti… Read more
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Request a sales quoteBioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration.
- Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications
- Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration
- Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments
1. Characteristics, surface/interface and biological effects on osteogenesis of bioactive materials
1.1. Fabrication methods of bioactive materials for bone regeneration
1.1.1. Material characteristics of bioactive materials for bone regeneration
1.1.2. Design of bioactive porous materials
1.1.3. Main challenges and prospects
Reference
1.2. Surface micro/nano structure regulation of bioactive materials for osteogenesis
1.2.1. Surface morphology of bioactive materials for osteogenesis
1.2.2. Porosity of bioactive porous materials for osteogenesis
1.2.3. Grain size of bioactive materials for osteogenesis
1.2.4. Summary
References
1.3. Protein adsorption on bioactive materials and its effect on osteogenesis
1.3.1. Current methods for protein adsorption study
1.3.2. The material factors influencing protein adsorption
1.3.3. The effect of protein adsorption on the osteogenesis of bioactive materials
1.3.4. Summary
References
1.4. Osteogenesis induced by bioactive porous materials and the related molecular mechanism
1.4.1. Angiogenesis of bioactive materials and the involved molecular mechanism
1.4.2. Osteogenesis of bioactive materials and the material-mediated MSCs function
1.4.3. Role of immunoresponse in osteogenesis of bioactive materials
1.4.4. Summary
References
2. Biomaterial-induced microenvironment and host reaction in bone regeneration
2.1. Bioactive inorganic ions for the manipulation of osteoimmunomodulation to improve bone regeneration
2.1.1. Introduction
2.1.2. Application of bioactive ions on developing bone biomaterials and its possible application in manipulating osteoimmunomodulation
2.1.3. Combine bioactive elements to develop novel bone biomaterials with osteoimmunomodulatory property and promote osteogenesis
2.1.4. Summaries and future prospects
References
2.2. Silicate-based bone cements for hard tissue regeneration
2.2.1. Preparation of silicate-based bone cement
2.2.2. The self-setting properties and drug delivery performance of silicate-based bone cement
2.2.3. The in vitro and in vivo bioactivity and osteoinductivity of silicate-based bone cement
References
2.3. Trace Element-based Biomaterials for OsteochondralRegeneration
2.3.1. Introduction
2.3.2. Biomaterials for osteochondral regeneration
2.3.3. Trace element-based biomaterials for osteochondral regeneration
2.3.4. Conclusions and Perspectives
References
2.4. Bioactive ions for bone tissue engineering design
2.4.1. Introduction
2.4.2 Effects of bioactive ions on the cell proliferation and stemness maintenance
2.4.3. Effects of bioactive ions on the osteogenesis and osteoclastogenesis
2.4.4. Effects of bioactive ions on the angiogenesis
2.4.5. The design of bioactive ions composite biomaterials for bone tissue engineering
2.4.6. Conclusions and Perspectives
References
3. Bone regeneration concept based on immune microenvironment regulation
3.1. Characteristics of immune microenvironment in biomaterial-based regeneration
3.1.1. Immune response after biomaterial implantation
3.1.2. Macrophage in bone-relevant physiological and pathological processes
3.1.3. T cells and B cells in bone-relevant physiological and pathological processes
3.1.4. Dendritic cells and NK cells in bone-relevant physiological and pathological processes
References
3.2 Biomaterials and its degradation products on immune microenvironment and regeneration
3.2.1. Metcmaterials implant and immune microenvironment and regeneration
3.2.2. Inorganic materials implant and immune microenvironment and regeneration
3.2.3. Organic materials implant and immune microenvironmentand regeneration
References
3.3. Biomaterial research and development aim to produce a “good” bone immune microenvironment by regulating the immune cell response and bone regeneration
3.3.1. Surface Properties Regulate Immune-mediated Osteogenesis
3.3.2. Particle Size Regulate Immune-mediated Osteogenesis
3.3.3. Microporosity Regulate Immune-mediated Osteogenesis
3.3.4. Ions Regulate Immune-mediated Osteogenesis
3.3.5. Summary and Expectation
References
- No. of pages: 248
- Language: English
- Edition: 1
- Published: February 28, 2020
- Imprint: Academic Press
- Paperback ISBN: 9780128135037
- eBook ISBN: 9780128135044
JC
Jiang Chang
XZ
Xingdong Zhang
KD