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Autophagy and Metabolism

Potential Target for Cancer Therapy

1st Edition - August 6, 2022

Editors: Dhruv Kumar, Shailendra Asthana

Paperback ISBN:

9 7 8 - 0 - 3 2 3 - 9 9 8 7 9 - 6

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 9 9 4 5 - 8

Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments.… Read more

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Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism.

This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Metabolic dysregulation in cancer progression
Abstract
1.1 Introduction
1.2 Impact of dysregulated metabolism on cancer progression
1.3 Metabolic reprogramming for anchorage-independent growth, and to form metastatic tumors
1.4 Targeting dysregulated cancer metabolism: a therapeutic perspective
1.5 Conclusion
References
Chapter 2. Molecular dynamics of autophagy in cancer metabolism
Abstract
2.1 Introduction
2.2 Autophagy
2.3 Molecular mechanism of macroautophagy
2.4 Autophagy regulation by metabolic stimuli
2.5 Molecular mechanism of autophagy regulation
2.6 Cancer regulation via autophagy
2.7 Therapeutics targeting autophagy
2.8 Conclusion
References
Chapter 3. Tumor cell metabolism and autophagy as therapeutic targets
Abstract
3.1 Introduction
3.2 Cancer metabolism in the tumor microenvironment
3.3 Metabolism of macrophages in tumor microenvironment
3.4 Altered metabolic enzymes
3.5 Role of autophagy in cancer
References
Chapter 4. Autophagy regulation in cancer: current knowledge on action and therapy
Abstract
4.1 Introduction
4.2 Regulation of autophagy
4.3 Anticancer autophagy inhibitors
4.4 Conclusion
References
Chapter 5. Signaling pathways in metabolic dysregulation in solid tumors
Abstract
5.1 Introduction
5.2 Metabolic pathways associated with tumor progression
5.3 Signaling pathways associated with solid tumors
5.4 Tissue-specific tumorigenesis and its metabolic dysregulation
5.5 Therapeutic approaches targeting oncogenic signaling in solid tumor
5.6 Conclusions and future directions
References
Chapter 6. Autophagy in arsenic exposed population and cancer patients
Abstract
6.1 Global arsenic scenario
6.2 Indian arsenic scenario
6.3 Bihar arsenic scenario
6.4 Cancer scenario
6.5 Disease cause
6.6 Autophagy in arsenic exposed population
6.7 Autophagy in cancer patients
6.8 Conclusion
References
Chapter 7. Autophagy in cancer-associated fibroblasts: biology and targeting
Abstract
7.1 Introduction
7.2 Cancer-associated fibroblast
7.3 Autophagy in cancer-associated fibroblast in cancer progression
7.4 Targeting cancer-associated fibroblast autophagy for oncologic treatment
Funding
References
Chapter 8. Autophagy and metabolic regulation in cancer and its application in drug discovery
Abstract
8.1 Introduction
8.2 Molecular mechanism of autophagy
8.3 Initiation of phagophore formation
8.4 Elongation
8.5 Maturation and fusion
8.6 Major autophagy-regulating targets
8.7 Autophagy and cancers
8.8 Mechanism of tumor suppression
8.9 Mechanism of tumor promotion
8.10 Therapeutic targets of autophagy in cancers
8.11 Conclusions and prospects
References
Chapter 9. Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming
Abstract
9.1 Introduction
9.2 Mitochondrial function and dynamics
9.3 Introduction to mitophagy
9.4 The mechanism of mitophagy
9.5 Mitophagy and diseases
9.6 Mitophagy and cancer
9.7 Mitophagy and cancer stem cells
9.8 Mitophagy in cancer stem cell drug-resistance
9.9 Concluding remarks
References
Chapter 10. Combined targeting autophagy and metabolism for cancer therapy
Abstract
10.1 Introduction
10.2 Autophagy: an introduction
10.3 Molecular mechanism of autophagy
10.4 Autophagy and cancer
10.5 Role of autophagy inducers in cancer therapy
10.6 Role of autophagy inhibitors in cancer therapy
10.7 Conclusion
References
Chapter 11. Designing metabolic target-specific inhibitors for cancer therapy
Abstract
11.1 Introduction
11.2 Role of metabolic target-specific inhibitors for cancer therapeutics
11.3 Conclusion
Acknowledgments
Conflict of Interest
Author contributions
Abbreviations
References
Chapter 12. Interplay between gut microbiota and autophagy in human health
Abstract
12.1 Autophagy
12.2 Gut microbiota
12.3 Interplay between autophagy and gut microbiota
12.4 Fecal microbiota transplantation—in rescue of gut microbiota and intestinal autophagy
12.5 Conclusion
References
Chapter 13. Autophagy in infection-mediated cancers
Abstract
13.1 Introduction
13.2 Mechanism and regulation of autophagy
13.3 Infection and autophagy
13.4 Autophagy and cancers
13.5 Correlation between infection and cancer
13.6 Infections leading to cancers
13.7 Autophagy in viral cancers
13.8 Autophagy in bacteria mediated cancers
13.9 Autophagy in parasite-associated infections in cancer
13.10 Bigger picture
13.11 Targeting autophagy in infection-mediated cancers
13.12 Conclusion
References
Index

Dhruv Kumar

Dr. Dhruv Kumar is a Senior Associate Professor at School of Health Sciences and Technology, UPES University, Dehradun, India and his current research is focused on autophagy, cancer cell metabolism, tumour microenvironment, exosomes, mutational heterogeneity, cancer prevention, drug designing, NGS and COVID-19. After completion of B.Sc. in Chemistry from Banaras Hindu University (BHU) and M.Sc. in Bioinformatics from University of Allahabad, India, he has completed his Ph.D. in Cellular, Molecular and Industrial Biology from the University of Bologna (UNIBO), under highly prestigious fellowship, Indo-Italian Government fellowship. After his Ph.D., he obtained Postdoctoral training at the University of Kansas Medical Center, USA. During his Postdoctoral training, he worked towards understanding the molecular mechanism(s) of autophagy regulation and apoptosis in cancer stem cells (prostate, pancreatic and breast), focusing on the metabolic cross-talk between the tumour microenvironment (cancer associated fibroblast (CAF)) and head and neck squamous cell carcinoma (HNSCC) via HGF/c-MET and bFGF/FGFR signalling pathways. He has also worked on structure based drug designing for several cancers, COVID-19, mutational heterogeneity in cancer. Currently, his lab is focusing on metabolic heterogeneity in solid tumours and structure based drug designing for cancer and COVID-19. He has published more than 100 research articles, reviews and book chapters in reputed journals.

Affiliations and expertise

Senior Associate Professor at School of Health Sciences and Technology, UPES University, Dehradun, India

Shailendra Asthana

Shailendra Asthana is a Senior Scientist at Translational Health Science and Technology Institute (THSTI), India. He has more than 20 years of research experience in drug discovery, autophagy, and bioinformatics. The goal of his research is to improve atomic level understanding of protein-ligand, protein-nucleic acid, protein-peptide and protein-protein interactions using computational models and tools. Using molecular modeling, molecular docking and physics-based methods such as molecular dynamics simulations, Dr. Asthana and his research group focus on how small molecules interact with proteins and thereby modulate their function.

Affiliations and expertise

Senior Scientist, Translational Health Science and Technology Institute (THSTI), India