Autophagy and Metabolism
Potential Target for Cancer Therapy
- 1st Edition - August 6, 2022
- Editors: Dhruv Kumar, Shailendra Asthana
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 8 7 9 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 9 4 5 - 8
Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatment… Read more
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Request a sales quoteAutophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism.
This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.
- Presents valuable and updated information on the mechanisms of autophagy in cancer metabolism
- Discusses the various metabolic pathways linked with autophagy that can be a major target for chemotherapeutic strategies
- Explains how autophagy supports tumor growth by activating metabolic phenotypes in cancer cells and the therapeutic interventions available to halt the process
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Metabolic dysregulation in cancer progression
- Abstract
- 1.1 Introduction
- 1.2 Impact of dysregulated metabolism on cancer progression
- 1.3 Metabolic reprogramming for anchorage-independent growth, and to form metastatic tumors
- 1.4 Targeting dysregulated cancer metabolism: a therapeutic perspective
- 1.5 Conclusion
- References
- Chapter 2. Molecular dynamics of autophagy in cancer metabolism
- Abstract
- 2.1 Introduction
- 2.2 Autophagy
- 2.3 Molecular mechanism of macroautophagy
- 2.4 Autophagy regulation by metabolic stimuli
- 2.5 Molecular mechanism of autophagy regulation
- 2.6 Cancer regulation via autophagy
- 2.7 Therapeutics targeting autophagy
- 2.8 Conclusion
- References
- Chapter 3. Tumor cell metabolism and autophagy as therapeutic targets
- Abstract
- 3.1 Introduction
- 3.2 Cancer metabolism in the tumor microenvironment
- 3.3 Metabolism of macrophages in tumor microenvironment
- 3.4 Altered metabolic enzymes
- 3.5 Role of autophagy in cancer
- References
- Chapter 4. Autophagy regulation in cancer: current knowledge on action and therapy
- Abstract
- 4.1 Introduction
- 4.2 Regulation of autophagy
- 4.3 Anticancer autophagy inhibitors
- 4.4 Conclusion
- References
- Chapter 5. Signaling pathways in metabolic dysregulation in solid tumors
- Abstract
- 5.1 Introduction
- 5.2 Metabolic pathways associated with tumor progression
- 5.3 Signaling pathways associated with solid tumors
- 5.4 Tissue-specific tumorigenesis and its metabolic dysregulation
- 5.5 Therapeutic approaches targeting oncogenic signaling in solid tumor
- 5.6 Conclusions and future directions
- References
- Chapter 6. Autophagy in arsenic exposed population and cancer patients
- Abstract
- 6.1 Global arsenic scenario
- 6.2 Indian arsenic scenario
- 6.3 Bihar arsenic scenario
- 6.4 Cancer scenario
- 6.5 Disease cause
- 6.6 Autophagy in arsenic exposed population
- 6.7 Autophagy in cancer patients
- 6.8 Conclusion
- References
- Chapter 7. Autophagy in cancer-associated fibroblasts: biology and targeting
- Abstract
- 7.1 Introduction
- 7.2 Cancer-associated fibroblast
- 7.3 Autophagy in cancer-associated fibroblast in cancer progression
- 7.4 Targeting cancer-associated fibroblast autophagy for oncologic treatment
- Funding
- References
- Chapter 8. Autophagy and metabolic regulation in cancer and its application in drug discovery
- Abstract
- 8.1 Introduction
- 8.2 Molecular mechanism of autophagy
- 8.3 Initiation of phagophore formation
- 8.4 Elongation
- 8.5 Maturation and fusion
- 8.6 Major autophagy-regulating targets
- 8.7 Autophagy and cancers
- 8.8 Mechanism of tumor suppression
- 8.9 Mechanism of tumor promotion
- 8.10 Therapeutic targets of autophagy in cancers
- 8.11 Conclusions and prospects
- References
- Chapter 9. Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming
- Abstract
- 9.1 Introduction
- 9.2 Mitochondrial function and dynamics
- 9.3 Introduction to mitophagy
- 9.4 The mechanism of mitophagy
- 9.5 Mitophagy and diseases
- 9.6 Mitophagy and cancer
- 9.7 Mitophagy and cancer stem cells
- 9.8 Mitophagy in cancer stem cell drug-resistance
- 9.9 Concluding remarks
- References
- Chapter 10. Combined targeting autophagy and metabolism for cancer therapy
- Abstract
- 10.1 Introduction
- 10.2 Autophagy: an introduction
- 10.3 Molecular mechanism of autophagy
- 10.4 Autophagy and cancer
- 10.5 Role of autophagy inducers in cancer therapy
- 10.6 Role of autophagy inhibitors in cancer therapy
- 10.7 Conclusion
- References
- Chapter 11. Designing metabolic target-specific inhibitors for cancer therapy
- Abstract
- 11.1 Introduction
- 11.2 Role of metabolic target-specific inhibitors for cancer therapeutics
- 11.3 Conclusion
- Acknowledgments
- Conflict of Interest
- Author contributions
- Abbreviations
- References
- Chapter 12. Interplay between gut microbiota and autophagy in human health
- Abstract
- 12.1 Autophagy
- 12.2 Gut microbiota
- 12.3 Interplay between autophagy and gut microbiota
- 12.4 Fecal microbiota transplantation—in rescue of gut microbiota and intestinal autophagy
- 12.5 Conclusion
- References
- Chapter 13. Autophagy in infection-mediated cancers
- Abstract
- 13.1 Introduction
- 13.2 Mechanism and regulation of autophagy
- 13.3 Infection and autophagy
- 13.4 Autophagy and cancers
- 13.5 Correlation between infection and cancer
- 13.6 Infections leading to cancers
- 13.7 Autophagy in viral cancers
- 13.8 Autophagy in bacteria mediated cancers
- 13.9 Autophagy in parasite-associated infections in cancer
- 13.10 Bigger picture
- 13.11 Targeting autophagy in infection-mediated cancers
- 13.12 Conclusion
- References
- Index
- No. of pages: 362
- Language: English
- Edition: 1
- Published: August 6, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323998796
- eBook ISBN: 9780323999458
DK
Dhruv Kumar
SA