Autonomic Dysfunction in Parkinson's Disease

1st Edition, Volume 1 - September 28, 2021
Imprint: Academic Press
Editors: Cristian Falup-Pecurariu, Peter Jenner
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 1 2 2 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 1 2 3 - 7

Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson’s disease. Autonomic Dysfunction in Parkinson's Disease provides up to date informati… Read more

Autonomic Dysfunction in Parkinson's Disease

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Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson’s disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Autonomic nervous system—Anatomy, physiology, biochemistry
Abstract
1: Anatomy of the autonomic nervous system (ANS)
2: Physiology and biochemistry of the autonomic nervous system
3: Autonomic control of selected organ systems
Chapter Two: General approach to patients with autonomic dysfunction in Parkinson's disease
Abstract
1: Introduction
2: Epidemiology
3: Pathophysiology
4: Clinical expression
5: Diagnosis
6: Treatment
7: Prognosis
8: Conclusion
Acknowledgments
Chapter Three: Rating scales for dysautonomia in Parkinson's disease
Abstract
1: Introduction
2: Method
3: Scales
4: General assessment scales
5: Dysautonomia rating scales
6: Symptom specific scales
7: Sexual dysfunction
Chapter Four: Assessing autonomic dysfunction with functional imaging in Parkinson's disease
Abstract
1: Introduction
2: Imaging synaptic dysfunction and denervation of the autonomic nervous system
3: Imaging functional disturbances of the autonomic nervous system
4: Conclusion
Chapter Five: Cardiovascular autonomic failure in Parkinson's disease
Abstract
1: Introduction
2: Clinical presentation of cardiovascular autonomic failure in PD
3: Diagnostic work-up of cardiovascular autonomic failure
4: Treatment of cardiovascular autonomic failure in PD
5: Summary
Chapter Six: Drooling and dysphagia in Parkinson's disease
Abstract
1: Introduction
2: Physiology of salivation and swallowing
3: Pathophysiology of drooling and dysphagia in PD
4: Prevalence of drooling and dysphagia and clinical correlates
5: Evaluation of drooling and dysphagia in PD
6: Treatment options for drooling in PD
7: Treatment options for dysphagia in PD
8: Conclusion
Chapter Seven: Gastrointestinal dysfunction in Parkinson's disease
Abstract
1: Introduction and historical perspective
2: Epidemiology of gastrointestinal dysfunction in Parkinson's disease
3: The enteric nervous system
4: Pathophysiology of gastrointestinal dysfunction in Parkinson's disease
5: Braak staging and the dual hit theory
6: Microbiota and Parkinson's disease
7: The brain-gut-microbiota axis
8: Treatment of gastrointestinal dysfunction in Parkinson's disease
9: Looking forward
10: Conclusions
Chapter Eight: Urinary dysfunction in Parkinson's disease
Abstract
1: Introduction
2: The basic neurology of micturition and how it is affected in Parkinson's disease
3: Symptoms and prevalence of urinary dysfunction in Parkinson's disease
4: Lower urinary tract symptoms in multiple system atrophy: Key distinguished features
5: Investigations for urinary dysfunction in Parkinson's disease
6: Management of urinary dysfunction in Parkinson's disease
7: Conclusion
Chapter Nine: Autonomic dysfunction during sleep in Parkinson's disease
Abstract
1: Introduction
2: Neuroanatomical and neurophysiological aspects linking sleep and the autonomic nervous system
3: Sleep disorders in PD associated with or causing autonomic dysfunction
4: Autonomic dysfunction associated with PD causing sleep disturbances
5: Conclusions
Chapter Ten: Thermoregulatory dysfunctions in idiopathic Parkinson's disease
Abstract
1: Pathogenesis
2: Symptoms
3: Diagnosis of sudomotor dysfunction in Parkinson's disease
4: Management of thermoregulatory symptoms in Parkinson's disease

Cristian Falup-Pecurariu

Cristian Falup-Pecurariu is Head of the Department of Neurology, County Clinic Hospital from Brasov, and is Full Professor of Neurology at the Transilvania University from Brasov, Romania. He received his medical degree from the University of Medicine and Pharmacy “Iuliu Hatieganu” from Cluj-Napoca. He hold a 1 year fellowship of the European Neurological Society in movement disorders at Hospital Clinic, University of Barcelona, Spain.

During his career Cristian Falup-Pecurariu was President of the European Association of Young Neurologists and Trainees (EAYNT), EAYNT Liasion Officer with World Federation of Neurological Society, co-representative of Europe on the International Working Group for Young Neurologists and Trainees (World Federation of Neurology). He was also Secretary of the EFNS/MDS-ES Panel on Movement Disorders, member of the Educational Committee of MDS-ES, member of the MDS Leadership Task Force and European Academy of Neurology Scientific Panel Movement Disorders, member of the Teaching Course sub-Committee of the European Academy of Neurology (EAN), currently being member of the Program Committee of EAN. Falup-Pecurariu is former Chair of the Education Committee of the MDS-ES, former member of the Executive Committee of MDS-ES, former member of the International Executive Committee of MDS. He is the initiator and Course Director of the Movement Disorders Teaching Course held in Brasov (12^th editions). His research focuses on motor and non-motor aspects of Parkinson’s diseases.

Affiliations and expertise

Chair, Department of Neurology, County Emergency Clinic Hospital, Associate Professor of Neurology, Faculty of Medicine, Transilvania University, Brasov, Romania

Peter Jenner

Professor Peter Jenner is a specialist in preclinical aspects of neurodegenerative diseases, notably Parkinson’s disease. He has spent the major part of his career at King’s College London where he was Head of Pharmacology for 14 years before returning to his research roots and subsequently becoming Emeritus Professor of Pharmacology. Peter has expertise in drug metabolism and pharmacokinetics but neuropharmacology based on functional models of neurodegenerative diseases has formed the major focus of his work. Peter holds a BPharm, PhD and DSc degree from the University of London. He has published well over 1000 articles with more than 700 peer reviewed papers. He is a Fellow of the Royal Pharmaceutical Society, the British Pharmacological Society, the Royal Society of Medicine and of King’s College London. Peter was recently honoured with a Doctor Honoris Causa degree from Carol Davila University of Medicine and Pharmacy, Bucharest and made an Honorary Fellow of The British Pharmacological Society for his contribution to research in to movement disorders. Peter has worked closely with the pharmaceutical industry for many years and acts as an adviser and consultant to both major pharma and biotech companies. He has a wide knowledge of the drug discovery and drug development process and has been involved from molecule synthesis through to drug registration for use in man. Peter was the Founder, Director and Chief Scientific Officer of Proximagen, a biotech focussed on the treatment and cure of neurodegenerative diseases that was listed on AIMs and subsequently purchased by a US based healthcare company. He is a regular speaker at international meetings and also takes time to speak at Parkinson’s disease patient-carer groups across the UK.

Affiliations and expertise

Emeritus Professor of Pharmacology, Institute of Pharmaceutical Sciences, King’s College London, London, UK

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