Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination
- 1st Edition, Volume 1 - December 3, 2022
- Latest edition
- Editors: Yehuda Shoenfeld, Arad Dotan
- Language: English
Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine.… Read more
Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist.
As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.
- Describe the short and long impact of COVID-19 on autoimmunity
- Provides understanding to the acute and chronic impact of the SARS-CoV-2
- Gives insights into the long-term effects of COVID-19 on recovered patients
- Provides conclusions on the novel terms "chronic post-COVID-19 syndrome", "post-acute COVID-19 syndrome", and "long COVID-19"
1. Introduction
The SARS-CoV-2 as an instrumental trigger of autoimmunity
The mosaic of autoimmunity: SARS-CoV- as an environmental factor
2. Cellular and molecular mechanisms in COVID-19
Innate immunity
Adaptive immunity
Cytokines and chemokines
Genetic predisposition
Molecular mimicry
Hyperferritinemic syndromes
Complement
3. Autoantibodies in COVID-19
Autoantibodies as a pre-clinical phase of autoimmunity
Coagulation dysfunction related autoaintibodies
Classical autoantibodies (ANA, RF, Ro52, anti-Ro60, p-ANCA, c-ANCA, etc
Antibodies could be driving severe COVID-19: Anti-interferon autoantibodies
ACE-2 receptor: the port of entry to the cell Anti ACE-2 F
4. Autoimmune manifestations and diseases in COVID-19
Humeral disorders and thrombosis
Neuropathies
Rheumatic diseases
Kawasaki-like disease
Olfactory
Additional immune-mediated manifestations
5. Peculiar aspects in COVID-19
Gender impact on COVID-19
Microbiome and COVID-19
Fertility related autoantibodies and Reproductive injury
COVID-19 and pregnancy
Side effects of the COVID-19 vaccines
6. Chronic post-COVID-19 syndromes
Disease course and mechanisms
Autoantibodies against the adrenergic nervous system
Long-term assessment of autoantibodies in COVID-19
Symptoms, diagnosis and epidemiology
Treatment and Prevention
- Edition: 1
- Latest edition
- Volume: 1
- Published: December 3, 2022
- Language: English
YS
Yehuda Shoenfeld
AD