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Atlas of Hematopathology with 100 Case Studies
1st Edition - June 3, 2024
Authors: Faramarz Naeim, P. Nagesh Rao, Sophie X. Song
Language: English
Hardback ISBN:9780443188381
9 7 8 - 0 - 4 4 3 - 1 8 8 3 8 - 1
eBook ISBN:9780443188398
9 7 8 - 0 - 4 4 3 - 1 8 8 3 9 - 8
Atlas of Hematopathology with 100 Case Studies is a practical guide useful for pathologists and hematologists, residents and fellows, laboratory directors, researchers, and studen…Read more
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Atlas of Hematopathology with 100 Case Studies is a practical guide useful for pathologists and hematologists, residents and fellows, laboratory directors, researchers, and students in the field of hematology, cytogenetic, and molecular pathology. The book offers important information to practicing physicians and those in pathology and hematology training to improve their diagnostic skills. It covers the most important aspects of hematopathology, including classifications, clinical symptoms, hematopathologic features, diagnostic criteria, differential diagnosis, and the use and importance of ancillary testing, such as immunohistochemistry, flow cytometry, and cytogenetics.
Includes case studies that provide a brief clinical history, along with images with relevant questions and answers
Provides user-friendly tables and graphs, along with correlations between microscopic findings and images of ancillary test results
Features over 250 color photographs that demonstrate various pathologic aspects of the disease
Pathologists, pathology residents and fellows, Hematologists and hematology/oncology fellows, A reference book for laboratory directors, and basic researchers in the field of hematology, cytogenetic and molecular pathology.
Cover image
Title page
Table of Contents
Copyright
Preface
Acknowledgment
Chapter 1. Hematology associated structures
Bone marrow
Blood
Lymph nodes
Spleen
Extramedullar hematopoiesis
Chapter 2. Disorders of bone marrow structure and function
Hypocellular bone marrows
Hypercellular bone marrows
Granulomas-reactive histiocytic hyperplasia
Other bone marrow lesions
Chapter 3. Disorders of white blood cells and platelets
Qualitative abnormalities in the granulocytic series
Quantitative abnormalities in the granulocytic series
Monocytosis and monocytopenia
Lymphocytosis and lymphocytopenia
Quantitative abnormalities in platelets
Qualitative disorders of platelets
Acquired platelet disorders
Chapter 4. Disorders of red blood cells
Abnormal morphology
Congenital dyserythropoietic anemias
Macrocytic anemias
Microcytic anemias
Sickle cell disease
Erythrocyte membrane skeleton defects
Erythrocyte enzyme deficiencies
Autoimmune hemolytic anemias
Other types of anemia
Chapter 5. Reactive lymphadenopathies
Follicular pattern
Paracortical (interfollicular) pattern
Sinus pattern
Granulomatous pattern
Mixed pattern
Chapter 6. Histiocytic and dendritic cell disorders
Histiocytic disorders
Dendritic cell disorders
Chapter 7. Myeloproliferative neoplasms
Chronic myeloid leukemia
Polycythemia vera
Primary myelofibrosis
Essential thrombocythemia
Chronic neutrophilic leukemia
Chronic eosinophilic leukemia
Juvenile myelomonocytic leukemia
MPN, not otherwise specified
Chapter 8. Mastocytosis
Classification
Pathology
Differential diagnosis
Chapter 9. Myelodysplastic neoplasms and myelodysplastic/myeloproliferative neoplasms
Myelodysplastic neoplasms
Myelodysplastic/myeloproliferative neoplasms
Chapter 10. Acute myeloid leukemia and myeloid sarcoma
AML with defining genetic abnormalities
Acute myeloid leukemia, defined by differentiation
Myeloid sarcoma
Chapter 11. Secondary myeloid neoplasms
Myeloid neoplasms post-cytotoxic therapy
Myeloid neoplasms associated with germline predisposition
Chapter 12. Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions and acute leukemias of mixed or ambiguous lineage
Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions
Acute leukemias of mixed or ambiguous lineage
Chapter 13. Lymphoblastic leukemias/lymphomas
B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
T-lymphoblastic leukemia/lymphoma (T-ALL)
Chapter 14. Mature B-cell neoplasms: Group 1
Preneoplastic and neoplastic small lymphocytic proliferations
Splenic B-cell lymphomas and leukemias
Lymphoplasmacytic lymphoma
Marginal zone lymphomas
Follicular lymphomas
Primary cutaneous follicle center lymphoma
Mantle cell lymphomas
Transformations of indolent B-cell lymphomas
Chapter 15. Mature B-cell neoplasms: Group 2: Large B-cell and high-grade B-cell lymphomas
Large B-cell lymphomas
Burkitt lymphoma
KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
Chapter 16. Mature B-cell neoplasms. Group 3: Hodgkin lymphomas
Classic Hodgkin lymphoma
Nodular lymphocyte predominant Hodgkin lymphoma
Chapter 17. Mature B-cell neoplasms. Group 4: Plasma cell neoplasms and other causes of paraproteins
Monoclonal gammopathies
Diseases with monoclonal immunoglobulin deposition
Heavy chain diseases
Plasma cell neoplasms
Chapter 18. Mature T-cell and NK-cell neoplasms: Group 1
Mature T-cell and NK-cell leukemias
Primary cutaneous T-cell lymphomas
Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
Chapter 19. Mature T-cell and NK-cell neoplasms: Group 2
Hepatosplenic T-cell lymphoma
Anaplastic large cell lymphoma
Nodal T-follicular helper (TFH) cell lymphoma
Peripheral T-cell lymphoma, not otherwise specified
EBV-positive NK/T-cell lymphomas
EBV-positive T- and NK-cell lymphoid proliferations and lymphomas of childhood
Dr. Faramarz Naeim is Professor Emeritus of Pathology, David Geffen School of Medicine, UCLA. He graduated from Tehran University School of Medicine and received his training in Pathology at Mallory Institute of Pathology, Boston City Hospital and Department of Pathology at UCLA School of Medicine. He has provided clinical services as a hematopathologist for 43 years, 30 years at UCLA, Department of Pathology and Laboratory Medicine, and 13 years at VA Greater Los Angeles Healthcare System, Department of Pathology and Laboratory Medicine. Dr. Naeim has published several books and book chapters in hematopathology and numerous articles in peer review journals.
Affiliations and expertise
Professor Emeritus, Department of Pathology, David Geffen UCLA School of Medicine, Hematopathologist, Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
PR
P. Nagesh Rao
Dr. Rao is an established Elsevier author. Current projects include analysis of cytogenetic abnormalities in Paget's disease patients and analyzing the mouse karyotypes for identifying XXY males among the offspring of female chimeras from embryonic stem-cells. His cytogenetics laboratory is a training site for interested residents, fellows and medical students.
Affiliations and expertise
Professor, Pathology and Laboratory Medicine, and Pediatrics, Chief, UCLA Cytogenetics Center, David Geffen UCLA School of Medicine, CA, USA
SS
Sophie X. Song
Dr. Sophie Song is a practicing board-certified hematopathologist. Dr. Song has a Ph.D. in Biochemistry, post-doctoral training in Cellular Immunology, and in-depth technical knowledge in flow cytometry that was developed while working as a research scientist at Biotech industry. Following her research experiences, Dr. Song completed her Pathology residency and Hematopathology fellowship at UCLA, and became faculty member at the Department of Pathology and Laboratory Medicine at UCLA in 2003. Since 2005, she has served as the Director of Clinical Flow Cytometry and Bone Marrow Laboratories at UCLA.
Affiliations and expertise
Professor, Director, Clinical Flow Cytometry & Bone Marrow Laboratories, Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, CA, USA
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