Atlas of Hematopathology with 100 Case Studies
- 1st Edition - June 14, 2024
- Latest edition
- Authors: Faramarz Naeim, P. Nagesh Rao, Sophie X. Song
- Language: English
Atlas of Hematopathology with 100 Case Studies is a practical guide useful for pathologists and hematologists, residents and fellows, laboratory directors, researchers, and studen… Read more
Atlas of Hematopathology with 100 Case Studies is a practical guide useful for pathologists and hematologists, residents and fellows, laboratory directors, researchers, and students in the field of hematology, cytogenetic, and molecular pathology. The book offers important information to practicing physicians and those in pathology and hematology training to improve their diagnostic skills. It covers the most important aspects of hematopathology, including classifications, clinical symptoms, hematopathologic features, diagnostic criteria, differential diagnosis, and the use and importance of ancillary testing, such as immunohistochemistry, flow cytometry, and cytogenetics.
- Includes case studies that provide a brief clinical history, along with images with relevant questions and answers
- Provides user-friendly tables and graphs, along with correlations between microscopic findings and images of ancillary test results
- Features over 250 color photographs that demonstrate various pathologic aspects of the disease
Pathologists, pathology residents and fellows, Hematologists and hematology/oncology fellows, A reference book for laboratory directors, and basic researchers in the field of hematology, cytogenetic and molecular pathology.
1. Bone marrow evaluation.
2. White blood cells.
3. Red blood cells.
4. Dendritic cell and histiocytic disorders.
5. Myelodysplastic and related neoplasms.
6. Myeloproliferative Neoplasms and related disorders.
7. Acute Myeloid Leukemias (AML) and related disorders.
Definition and morphologic features of immature cells
AML with recurrent genetic abnormalities
AML with myelodysplasia-related changes
Therapy-related AML
AML not otherwise specified
AML minimally differentiated
AML without maturation
AML with maturation
Acute myelomonocytic leukemia
Acute monoblastic and monocytic leukemia
Acute erythroid leukemia
Acute megakaryoblastic leukemia
Acute basophilic leukemia
Acute panmyelosis with myelofibrosis
Myeloid sarcoma
Myeloid proliferations related to Down syndrome
8. B-Lymphoblastic Leukemia/Lymphoma (B-ALL).
Definition and classification
A. lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
B-LBLL with t(9;22)(q34.1;q11.2);BCR-ABL1
B-LBLL with t(4;11)(q21;q23) (AFF1- KMT2A) and variants
B-LBLL with t(12;21)(p13.2;q22.1); ETV6-RUNX
B-LBLL with t(1;19)(q23;p13.3);TCF3-PBX1
B-LBLL with t(5;14)(q31.1;q32.3) IL3-IGH
B-LBLL with hyperdiploidy
B-LBLL with hypodiploidy
B-LBLL, BCR-ABL1-like
B-LBLL with iAMP21=
B. lymphoblastic leukemia/lymphoma, not otherwise specified (NOS)
9. Mature B-Cell Neoplasms.
Definition and classification
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
Prolymphocytic leukemia
Hairy cell leukemia
Lymphoplasmacytic lymphoma
Splenic marginal zone B-cell lymphoma
Nodal marginal zone B-cell lymphoma
Mucosa-associated lymphoid tissue (MALT) lymphoma
Mantle cell lymphoma
Follicular lymphoma
Large B-cell lymphoma subtypes
Plasmablastic lymphoma
Burkitt lymphoma
10. T-Lymphoblastic Leukemia/Lymphoma (T-ALL)
Definition and classification
Early T-cell precursor ALL
Early cortical T-ALL
Late cortical T-ALL
Medullary T-ALL
Cytogenetic and molecular studies
11. T and NK Cell Neoplasms.
Definition and classification
Large granular lymphocytic leukemia
Extranodal NK/T-cell lymphoma, nasal type
T-cell prolymphocytic leukemia
Adult T-cell leukemia/lymphoma
Hepatosplenic T-cell lymphoma
Mycosis Fungoides and Sézary Syndrome
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphomas
Peripheral T-cell lymphoma, not otherwise specified
12. Hodgkin Lymphoma
Definition and classification
A. Nodular lymphocyte predominant Hodgkin lymphoma
B. Classical Hodgkin Lymphoma
Nodular sclerosis classical Hodgkin lymphoma (NSHL)
Mixed cellularity classical Hodgkin lymphoma (MCHL)
Lymphocyte-rich classical Hodgkin lymphoma (LRHL)
Lymphocyte-depleted classical Hodgkin lymphoma (LDHL).
13. Plasma Cell Neoplasms
Definition and classification
Monoclonal gammopathy of undetermined significance (MGUS)
Plasma cell myeloma
Plasma cell leukemia
Osteosclerotic myeloma (POEMS syndrome)
Plasmacytoma
Immunoglobulin light and heavy chain disease
14. Reactive Lymphadenopathies
Definition and classification
Follicular Hyperplasia
Castleman disease
Sinus histiocytosis with massive lymphadenopathy
Lymphohistiocytic hemophagocytosis
Sarcoidosis
Toxoplasmosis
Cat-scratch disease
Cytomegalovirus
Infectious mononucleosis
Kikuchi disease
Kimura disease
Dermatopathic lymphadenitis
2. White blood cells.
3. Red blood cells.
4. Dendritic cell and histiocytic disorders.
5. Myelodysplastic and related neoplasms.
6. Myeloproliferative Neoplasms and related disorders.
7. Acute Myeloid Leukemias (AML) and related disorders.
Definition and morphologic features of immature cells
AML with recurrent genetic abnormalities
AML with myelodysplasia-related changes
Therapy-related AML
AML not otherwise specified
AML minimally differentiated
AML without maturation
AML with maturation
Acute myelomonocytic leukemia
Acute monoblastic and monocytic leukemia
Acute erythroid leukemia
Acute megakaryoblastic leukemia
Acute basophilic leukemia
Acute panmyelosis with myelofibrosis
Myeloid sarcoma
Myeloid proliferations related to Down syndrome
8. B-Lymphoblastic Leukemia/Lymphoma (B-ALL).
Definition and classification
A. lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
B-LBLL with t(9;22)(q34.1;q11.2);BCR-ABL1
B-LBLL with t(4;11)(q21;q23) (AFF1- KMT2A) and variants
B-LBLL with t(12;21)(p13.2;q22.1); ETV6-RUNX
B-LBLL with t(1;19)(q23;p13.3);TCF3-PBX1
B-LBLL with t(5;14)(q31.1;q32.3) IL3-IGH
B-LBLL with hyperdiploidy
B-LBLL with hypodiploidy
B-LBLL, BCR-ABL1-like
B-LBLL with iAMP21=
B. lymphoblastic leukemia/lymphoma, not otherwise specified (NOS)
9. Mature B-Cell Neoplasms.
Definition and classification
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
Prolymphocytic leukemia
Hairy cell leukemia
Lymphoplasmacytic lymphoma
Splenic marginal zone B-cell lymphoma
Nodal marginal zone B-cell lymphoma
Mucosa-associated lymphoid tissue (MALT) lymphoma
Mantle cell lymphoma
Follicular lymphoma
Large B-cell lymphoma subtypes
Plasmablastic lymphoma
Burkitt lymphoma
10. T-Lymphoblastic Leukemia/Lymphoma (T-ALL)
Definition and classification
Early T-cell precursor ALL
Early cortical T-ALL
Late cortical T-ALL
Medullary T-ALL
Cytogenetic and molecular studies
11. T and NK Cell Neoplasms.
Definition and classification
Large granular lymphocytic leukemia
Extranodal NK/T-cell lymphoma, nasal type
T-cell prolymphocytic leukemia
Adult T-cell leukemia/lymphoma
Hepatosplenic T-cell lymphoma
Mycosis Fungoides and Sézary Syndrome
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphomas
Peripheral T-cell lymphoma, not otherwise specified
12. Hodgkin Lymphoma
Definition and classification
A. Nodular lymphocyte predominant Hodgkin lymphoma
B. Classical Hodgkin Lymphoma
Nodular sclerosis classical Hodgkin lymphoma (NSHL)
Mixed cellularity classical Hodgkin lymphoma (MCHL)
Lymphocyte-rich classical Hodgkin lymphoma (LRHL)
Lymphocyte-depleted classical Hodgkin lymphoma (LDHL).
13. Plasma Cell Neoplasms
Definition and classification
Monoclonal gammopathy of undetermined significance (MGUS)
Plasma cell myeloma
Plasma cell leukemia
Osteosclerotic myeloma (POEMS syndrome)
Plasmacytoma
Immunoglobulin light and heavy chain disease
14. Reactive Lymphadenopathies
Definition and classification
Follicular Hyperplasia
Castleman disease
Sinus histiocytosis with massive lymphadenopathy
Lymphohistiocytic hemophagocytosis
Sarcoidosis
Toxoplasmosis
Cat-scratch disease
Cytomegalovirus
Infectious mononucleosis
Kikuchi disease
Kimura disease
Dermatopathic lymphadenitis
- Edition: 1
- Latest edition
- Published: June 14, 2024
- Language: English
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Faramarz Naeim
Dr. Faramarz Naeim is Professor Emeritus of Pathology, David Geffen School of Medicine, UCLA. He graduated from Tehran University School of Medicine and received his training in Pathology at Mallory Institute of Pathology, Boston City Hospital and Department of Pathology at UCLA School of Medicine. He has provided clinical services as a hematopathologist for 43 years, 30 years at UCLA, Department of Pathology and Laboratory Medicine, and 13 years at VA Greater Los Angeles Healthcare System, Department of Pathology and Laboratory Medicine. Dr. Naeim has published several books and book chapters in hematopathology and numerous articles in peer review journals.
Affiliations and expertise
Professor Emeritus, Department of Pathology, David Geffen UCLA School of Medicine, Hematopathologist, Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USAPR
P. Nagesh Rao
Dr. Rao is an established Elsevier author. Current projects include analysis of cytogenetic abnormalities in Paget's disease patients and analyzing the mouse karyotypes for identifying XXY males among the offspring of female chimeras from embryonic stem-cells. His cytogenetics laboratory is a training site for interested residents, fellows and medical students.
Affiliations and expertise
Professor, Pathology and Laboratory Medicine, and Pediatrics, Chief, UCLA Cytogenetics Center, David Geffen UCLA School of Medicine, CA, USASS
Sophie X. Song
Dr. Sophie Song is a practicing board-certified hematopathologist. Dr. Song has a Ph.D. in Biochemistry, post-doctoral training in Cellular Immunology, and in-depth technical knowledge in flow cytometry that was developed while working as a research scientist at Biotech industry. Following her research experiences, Dr. Song completed her Pathology residency and Hematopathology fellowship at UCLA, and became faculty member at the Department of Pathology and Laboratory Medicine at UCLA in 2003. Since 2005, she has served as the Director of Clinical Flow Cytometry and Bone Marrow Laboratories at UCLA.
Affiliations and expertise
Professor, Director, Clinical Flow Cytometry & Bone Marrow Laboratories, Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, CA, USARead Atlas of Hematopathology with 100 Case Studies on ScienceDirect