Artificial Protein and Peptide Nanofibers

Design, Fabrication, Characterization, and Applications

1st Edition - July 24, 2020
Imprint: Woodhead Publishing
Editors: Gang Wei, Sangamesh G. Kum bar
Language: English
Paperback ISBN:
9 7 8 - 0 - 0 8 - 1 0 2 8 5 0 - 6
eBook ISBN:
9 7 8 - 0 - 0 8 - 1 0 2 8 5 1 - 3

Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization, and Applications provides comprehensive knowledge of the preparation, modification and applicati… Read more

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Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization, and Applications provides comprehensive knowledge of the preparation, modification and applications of protein and peptide nanofibers. The book reviews the synthesis and strategies necessary to create protein and peptide nanofibers, such as self-assembly (including supramolecular assembly), electrospinning, template synthesis, and enzymatic synthesis. Then, the key chemical modification and molecular design methods are highlighted that can be utilized to improve the bio-functions of these synthetic fibers. Finally, fabrication methods for key applications, such as sensing, drug delivery, imaging, tissue engineering and electronic devices are reviewed.

This book will be an ideal resource for those working in materials science, polymer science, chemical engineering, nanotechnology and biomedicine.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Foreword
Section A: Fabrication and characterizations of artificial protein and peptide nanofibers
1: Supramolecular self-assembly: A facile way to fabricate protein and peptide nanomaterials
Abstract
Acknowledgment
1.1: Introduction
1.2: Protein and peptide assembly mechanism
1.3: Application of protein and peptide nanomaterials
1.4: Conclusions
2: Self-assembly formation of peptide and protein nanofibers on surfaces and at interfaces
Abstract
Acknowledgments
2.1: Introduction
2.2: Self-assembly formation of peptide/protein nanofibers on material surface
2.3: Self-assembly formation of peptide and protein nanofibers at interfaces
2.4: Conclusions and outlooks
3: Fabrication of amyloid nanofiber matrices by electrospinning
Abstract
3.1: Introduction
3.2: Electrospinning
3.3: Electrospinning proteins
3.4: Conclusion
4: Novel protein and peptide nanofibrous structures via supramolecular co-assembly
Abstract
4.1: Introduction
4.2: Co-assembled peptide superstructures
4.3: Co-assembled protein superstructures
4.4: Conclusion
5: Characterization techniques of protein and peptide nanofibers: Self-assembly kinetics
Abstract
5.1: Introduction
5.2: Kinetic triggering for molecular self-assembly
5.3: Characterizations of self-assembly kinetics of nanofibers/nanofibrils
5.4: Summary
5.5: Conclusion and outlooks
Section B: Enhanced functions of nanofibers by sequence design and modification
6: Protein synthesis and characterization
Abstract
6.1: Introduction
6.2: Types of proteins
6.3: Protein structure
6.4: Applications of protein in medicine
6.5: Bioactive/functional peptides
6.6: Protein synthesis
6.7: Characterization of peptides and proteins
6.8: Conclusions
7: Design of functional peptide nanofibers based on amyloid motifs
Abstract
Acknowledgments
7.1: Introduction
7.2: Formation mechanism and secondary structures of functional amyloid nanofibers
7.3: Bio-applications of function-tailored amyloid nanofibers
7.4: Conclusions and outlooks
8: Design of amphiphilic peptide nanofibers
Abstract
8.1: Introduction
8.2: Amphiphilic peptide design
8.3: Self-assembled peptide nanofibers
8.4: Characterization methods for self-assembling amphiphilic peptides
8.5: Conclusions
9: Nanofiber matrices of protein mimetic bioactive peptides for biomedical applications
Abstract
9.1: Introduction
9.2: Protein mimetic bioactive peptide nanofibers
9.3: Biomedical applications of protein mimetic bioactive peptide nanofibers
9.4: Conclusion and future prospects
10: Synergetic integration of computer-aided design, experimental synthesis, and self-assembly for the rational design of peptide/protein nanofibrils
Abstract
Acknowledgments
10.1: Introduction
10.2: Simulation techniques for peptide/protein designs
10.3: Simulation strategies for peptide/protein sequence designs
10.4: Experimental methods for artificial peptide/protein synthesis
10.5: Fibrillation of artificial peptide/proteins
10.6: Conclusions
11: Composite nanofiber matrices for biomedical applications
Abstract
11.1: Introduction
11.2: Protein-based nanofiber composites and their interactions
11.3: Biomedical applications of composite nanofibers
11.4: Conclusion/future perspective
12: Nanofiber-based hydrogels and aerogels
Abstract
Acknowledgments
12.1: NFHGs are of great significance for in vitro culture of spheroid tumor models
12.2: Application in nerve repair
12.3: Application in drug delivery
12.4: Application in healing the wound
12.5: Application in separating oil/organic liquid and water
Section C: Related applications of artificial protein and peptide nanofibers
13: Protein and peptide nanostructures for drug and gene delivery
Abstract
Acknowledgment
13.1: Introduction
13.2: Albumin nanoparticles
13.3: Collagen nanoparticles
13.4: Gelatin nanoparticles
13.5: Elastin nanoparticles
13.6: Fibroin nanoparticles
13.7: Sericin nanoparticles
13.8: Keratin nanoparticles
13.9: Zein nanoparticles
13.10: Gliadin nanoparticles
13.11: Casein nanoparticles
13.12: Beta lactoglobulin nanoparticles
13.13: Lactoferrin nanoparticles
13.14: Legume protein nanoparticles
13.15: Soy protein-based nanoparticles
13.16: Lysozyme nanoparticles
13.17: Protein-modified nanoparticles
13.18: Role of cell penetrating peptides in drug and gene delivery
13.19: Self-assembled peptide structures
13.20: Emerging applications for protein and peptide-based delivery systems
13.21: Peptide-drug conjugates
13.22: Electrospun drug delivery systems
13.23: Concluding remarks
14: Protein and peptide nanofiber matrices for the regenerative medicine
Abstract
Acknowledgment
14.1: Proteins and peptides in tissue engineering and regenerative medicine
14.2: Fundamentals of proteins and peptides structures
14.3: Interaction of protein with substrate and role in the cell-materials interaction
14.4: Biofunctionalization of nanofiber-based scaffolds with proteins
14.5: Self-assembling peptides and proteins in bioengineering
14.6: Surface modification with peptides-based nanofibers for the tissue engineering applications
14.7: Naturally occurring and engineered proteins for the tissue regeneration applications
14.8: Summary
15: Fibrous scaffolds for bone tissue engineering
Abstract
15.1: Introduction
15.2: Bone cells and their microenvironment
15.3: Design considerations for fibrous scaffolds for bone tissue engineering
15.4: Methods for fibrous scaffold processing
15.5: Current findings in bone tissue engineering using nano- and micro-fibers
15.6: Conclusion and future trends using fibrous scaffold approaches
16: Assembled peptides for biomimetic catalysis
Abstract
Acknowledgment
16.1: Introduction
16.2: Enzyme models constructed by peptide assembly
16.3: Key issues for constructing peptide assembly enzyme mimics
16.4: Applications in the environment and healthcare
16.5: Perspective
17: New protein-based smart materials
Abstract
Acknowledgments
17.1: Introduction
17.2: Smart materials based on protein/hybrid self-assembly
17.3: Outlook and perspective
18: Nanofibers for soft-tissue engineering
Abstract
Acknowledgment
18.1: Introduction
18.2: Soft-tissue injuries
18.3: Soft-tissue engineering
18.4: Soft-tissue engineering using nanofiber matrices
18.5: Bioactive nanofiber matrices
18.6: Application of nanofiber matrices in soft-tissue engineering
18.7: Conclusion
Index

Gang Wei

Gang Wei received his Ph.D from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China, in 2007. Following the doctoral studies, he worked as the Alexander-von-Humboldt (2007) and Carl-Zeiss (2009) Postdoctoral Fellow at the Friedrich-Schiller-University of Jena, Germany. Since 2012, he has worked as a senior researcher and group leader in Hybrid Materials Interfaces Group at the University of Bremen, Germany. Since Feb 2018, he has been appointed as a guest professor at the Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences. His research interests include supramolecular self-assembly, biomimetic materials, two-dimensional nanomaterials, sensors and biosensors, as well as single molecule force spectroscopy. Up to now, he has published 100+ peer-reviewed papers in the journals like Chem. Soc. Rev., Prog. Polym. Sci., ACS Nano, Adv. Funct. Mater., Nanoscale Horizons, Nanoscale, Chem. Commun., J. Mater. Chem. B, and others.

Affiliations and expertise

Group Leader and Senior Researcher, University of Bremen, Bremen, Germany

Sangamesh G. Kum bar

Dr. Kumbar is an Assistant Professor in the Departments of Orthopaedic Surgery, Materials Science & Engineering and Biomedical Engineering at the University of Connecticut. His research is focused on synthesis and characterization of novel biomaterials for tissue engineering and drug delivery applications. These polymeric materials namely polysaccharides, polyphosphazenes, polyanhydrides, polyesters as well as blends of two or more of the polymeric materials and composites combining the polymeric materials with ceramics in the form of 3-dimentional porous structures will serve as scaffolds for variety of tissue engineering applications. Dr. Kumbar is an active member of Society for Biomaterials (SFB), Controlled Release Society (CRS), Materials Research Society (MRS) and Orthopaedic Research Society (ORS). Dr. Kumbar is serving as a reviewer for more than 25 journals in the field of biomaterials, drug delivery and tissue engineering. He has recently edited a book “Natural and Synthetic Biomedical Polymers” Elsevier Science & Technology, 2014- ISBN: 978-0-12-396983-5. He is also on the Editorial Board of more than 7 journals in the area of his expertise including Journal of Biomedical Materials Research-Part B, Journal of Applied Polymer Science, and Journal of Biomedical Nanotechnology.

Affiliations and expertise

University of Connecticut Health Center, USA

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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