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Applications of Nanoscience in Photomedicine
1st Edition - February 3, 2015
Editors: Michael R. Hamblin, Pinar Avci
Hardback ISBN:9781907568671
9 7 8 - 1 - 9 0 7 5 6 8 - 6 7 - 1
eBook ISBN:9781908818782
9 7 8 - 1 - 9 0 8 8 1 8 - 7 8 - 2
Nanoscience has become one of the key growth areas in recent years. It can be integrated into imaging and therapy to increase the potential for novel applications in the field of… Read more
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Nanoscience has become one of the key growth areas in recent years. It can be integrated into imaging and therapy to increase the potential for novel applications in the field of photomedicine. In the past commercial applications of nanoscience have been limited to materials science research only, however, in recent years nanoparticles are rapidly being incorporated into industrial and consumer products. This is mainly due to the expansion of biomedical related research and the burgeoning field of nanomedicine. Applications of Nanoscience in Photomedicine covers a wide range of nanomaterials including nanoparticles used for drug delivery and other emerging fields such as optofluidics, imaging and SERS diagnostics. Introductory chapters are followed by a section largely concerned with imaging, and finally a section on nanoscience-enabled therapeutics.
Covers a comprehensive up-to-date information on nanoscience
Focuses on the combination of photomedicine with nanotechnology to enhance the diversity of applications
Pioneers in the field have written their respective chapters
Opens a plethora of possibilities for developing future nanomedicine
Easy to understand and yet intensive coverage chapter by chapter
Nanotechnology specialists, scientists, engineers, physicians with interests in the areas of nanoscience, chemistry, physics, photomedicine, imaging, drug delivery, and related technologies
2.5 Wide-field high-sensitivity imaging of single nanoparticles and viruses using self-assembled nanolenses
2.6 Evaporating continuous films
2.7 Conclusions
Acknowledgements
Conflicts of interest statement
3: Photoacoustic imaging in nanomedicine
Abstract
3.1 Introduction
3.2 Fundamentals of photoacoustic imaging
3.3 Photoacoustic imaging systems
3.4 Exogenous contrasts for PAT
3.5 Conclusion
4: Chemical imaging of biological systems with nonlinear optical microscopy
Abstract
4.1 Introduction
4.2 Absorption spectroscopy
4.3 Emission microscopy
4.4 Vibrational microscopy
4.5 Nonresonant nonlinear microscopy
4.6 Conclusion
5: Photoluminescent quantum dots in imaging, diagnostics and therapy
Abstract
5.1 Introduction
5.2 Quantum dot electronic structure
5.3 Quantum dot bioconjugates
5.4 Multi-scale imaging applications with quantum dots
5.5 Therapeutic applications with quantum dots
5.6 Remaining challenges
5.7 Concluding remarks
Acknowledgements
5.9 Appendix – glossary of terms
6: Cell theranostics with plasmonic nanobubbles
Abstract
6.1 Introduction
6.2 Basic properties of plasmonic nanobubbles
6.3 Diagnostic, therapeutic and theranostic properties of plasmonic nanobubbles
7: Near-infrared fluorescence nanoparticle-based probes: application to in vivo imaging of cancer
Abstract
7.1 Introduction
7.2 Development of near-infrared fluorescence nanoprobes
7.3 Near-infrared fluorescence nanoprobes for cancer molecular imaging
7.4 Conclusion and perspectives
8: Optofluidics
Abstract
8.1 Introduction
8.2 Optofluidic structures
8.3 Optofluidic detection methods
8.4 Optofluidic preconcentration, trapping, and manipulation of nanoparticles
8.5 Optofluidic control of flow
Acknowledgements
9: Optofluidic lab-on-a-chip devices for photomedicine applications
Abstract
9.1 Introduction
9.2 Detection of human cells
9.3 Detection of nucleic acids
9.4 Conclusion
10: Optogenetics: lights, camera, action! A ray of light, a shadow unmasked
Abstract
10.1 Introduction
10.2 Overview – from birth to cradle
10.3 Optogenetics
10.4 Light delivery
10.5 Applications
10.6 Challenges
10.7 Conclusion
11: Photonic control of axonal guidance
Abstract
11.1 Introduction
11.2 Optical tweezers for axonal manipulation
11.3 Optically-driven micro-motor for axonal guidance
11.4 Neuronal beacon for axonal navigation
11.5 Future outlook and conclusions
12: Gold nanorods in photomedicine
Abstract
12.1 Introduction
12.2 Therapeutic applications
12.3 Therapeutic delivery
12.4 Probing diseases
12.5 Conclusion
13: Gold nanoparticles and their applications in photomedicine, diagnosis and therapy
Abstract
13.1 Introduction
13.2 Synthesis and functionalization of gold nanoparticles
13.3 Photomedicine
13.4 Gold nanoparticles in photothermal therapy
13.5 Use of gold nanoparticles in rheumatoid arthritis
13.6 Conclusion
14: Targeted gold nanoshells
Abstract
14.1 Introduction
14.2 Gold-based nanoshells
14.3 Passive targeting gold nanospheres
14.4 Active-targeting ligands
14.5 Outlook
Acknowledgements
15: Nanotube- and graphene-based photomedicine for cancer therapeutics
Abstract
15.1 Introduction
15.2 Nanotechnology
15.3 Carbon nanotubes
15.4 Carbon nanotubes for photothermal therapy
15.5 Combination photothermal therapy and chemotherapy based on carbon nanotubes
15.6 Rise of graphene
15.7 Graphene-based photomedicine
15.8 Photothermally enhanced photodynamic therapy of cancer
15.9 Combination of photothermal and chemotherapy based on graphene
15.10 Conclusions and outlook
Acknowledgements
16: Nanomaterial-assisted light-induced poration and transfection of mammalian cells
Abstract
16.1 Introduction
16.2 Transfection of mammalian cells
16.3 Combining nanomaterials and light for cell transfection: principles, functionalization and toxicity
16.4 Examples of nanomaterial-assisted light-induced optoporation and transfection of cells
16.5 Conclusions
Acknowledgements
17: Upconverting nanoparticle-based multi-functional nanoplatform for enhanced photodynamic therapy: promises and perils
Abstract
17.1 Introduction
17.2 History
17.3 Advantages
17.4 Upconverting nanoparticles
17.5 Upconverting nanoparticles in photodynamic therapy
17.6 Challenges
17.7 Future
18: Light-controlled nanoparticulate drug delivery systems
Abstract
18.1 Introduction
18.2 Drug delivery systems based on photocleavage of molecules
18.3 Drug delivery systems controlled by triggered photoisomerization
18.4 Nanoparticles triggered by photo-oxidation reactions
18.5 Drug delivery nanoparticles employing photopolymerization
18.6 Drug delivery systems based on metal nanoparticles
18.7 Phototargeted nanoparticles
18.8 Conclusions
19: Light-activated antimicrobial nanoparticles
Abstract
19.1 Antimicrobial PDT
19.2 Photodynamic therapy and nanoparticles
19.3 Conclusions and future trends
20: Silica-based nanostructured materials for biomedical applications
Abstract
20.1 Silica nanoparticles for photomedicine
20.2 Silica nanomaterials for photodynamic therapy
20.3 Incorporation of antioxidants in silica nanoparticles
20.4 Silica encapsulation of ultraviolet filters
20.5 Conclusions and outlook
Acknowledgements
21: Silica-based nanoparticles for photodynamic therapy
Abstract
21.1 Introduction
21.2 Noncovalent encapsulation of photosensitizers in silica nanoparticles
21.3 Covalent encapsulation of photosensitizer in silica nanoparticles
21.4 Nanoparticles partly made with silica
21.5 Conclusion
22: Supramolecular drug delivery platforms in photodynamic therapy
Abstract
22.1 Introduction to photodynamic therapy photophysical chemistry
22.2 Ideal properties of photosensitizers and the photosensitizer dilemma
22.3 Supramolecular interaction as a solution to photosensitizer issues, overview of supramolecular processes
22.4 Liposomal systems
22.5 Micelles, polymersomes, reverse micelles, and micellar-like systems
22.6 Miscellaneous supramolecular systems
22.7 Conclusion and future outlook
Acknowledgements
23: Advancing photodynamic therapy with biochemically tuned liposomal nanotechnologies
Abstract
23.1 Introduction
23.2 Photophysical and photochemical properties of liposomal photosensitizers
23.3 Applications: liposomes for photodynamic therapy
23.4 Applications: theranostic (or image-guided) photodynamic therapy with liposomes
23.5 Photosensitizer release mechanisms
23.6 Future directions and perspective
Acknowledgements
24: Porphyrin nanoparticles in photomedicine
Abstract
24.1 Porphyrins
24.2 Nanoparticles with porphyrin components
24.3 Porphyrin self-assembled nanoparticles
24.4 Conclusion
Acknowledgements
Index
No. of pages: 220
Language: English
Published: February 3, 2015
Imprint: Chandos Publishing
Hardback ISBN: 9781907568671
eBook ISBN: 9781908818782
MH
Michael R. Hamblin
Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and is a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. He was trained as a synthetic organic chemist and received his PhD from Trent University in England. His research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer, and heart disease and in low-level light therapy (LLLT) for wound healing, arthritis, traumatic brain injury and hair-regrowth. He directs a laboratory of around a sixteen post-doctoral fellows, visiting scientists and graduate students. His research program is supported by NIH, CDMRP, USAFOSR and CIMIT among other funding agencies. He has published 252 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents. He is Associate Editor for 7 journals, on the editorial board of a further 12 journals and serves on NIH Study Sections. For the past 9 years Dr Hamblin has chaired an annual conference at SPIE Photonics West entitled "Mechanisms for low level light therapy" and he has edited the 9 proceedings volumes together with four other major textbooks on PDT and photomedicine. He has several other book projects in progress at various stages of completion. In 2011 Dr Hamblin was honored by election as a Fellow of SPIE.
Affiliations and expertise
Harvard Medical School, Cambridge, MA, USA
PA
Pinar Avci
Pinar Avci, MD is a Research Fellow in Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School Department of Dermatology, Boston USA. She received her MD degree in General Medicine from Semmelweis University, and is currently pursuing her PhD in Department of Dermatology, Venereology and Dermato-oncology, Semmelweis University, Budapest, Hungary. She is currently conducting research in the area of Photodynamic therapy (PDT) – a localized approach for treatment of cancer and infections and its effects in developing anti-tumor immunity.
Affiliations and expertise
Research Fellow, Department of Dermatology, Harvard Medical School, Cambridge, MA, USA