
Applications of Advanced Omics Technologies: From Genes to Metabolites
- 1st Edition, Volume 64 - May 8, 2014
- Imprint: Elsevier
- Editors: Virginia García-Cañas, Alejandro Cifuentes, Carolina Simó
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 6 2 6 5 0 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 6 2 6 6 9 - 1
The book contains contributions concerning the application of the new instrumental and methodological developments in omics technologies, including those related to Genomics, Tr… Read more

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Request a sales quoteThe book contains contributions concerning the application of the new instrumental and methodological developments in omics technologies, including those related to Genomics, Transcriptomics, Proteomics, Peptidomics and Metabolomics, Lipidomics and Foodomics.The16 chapters discuss in detail: innovative applications of functional gene microarrays for profiling microbial communities, microRNA profiling, novel genotyping applications using microarray technology in cancer research, next-generation sequencing applied to the study of human microbiome, emerging RNA-SEQ applications in food science, recent progress in plant proteomics, applications of gel-free proteomic approaches, the challenges and applications of proteomics tools for food authenticity, the role of salivary peptidomics in clinical applications, metabolomic approaches to the study of degenerative, cardiovascular and renal diseases, and neonatal medicine. Also covered are other omics applications such as profiling of genetically modified organisms, the fundamentals, applications and challenges of foodomics, and MS-based lipidomics. Moreover, this volume includes relevant and updated aspects on bioinformatics, data treatment, data integration and systems biology. This book complements the previous volume "Fundamentals of Advanced Omics Technologies: New Advances from Genes to Metabolites" that covered the fundamental aspects of these new omics technologies.
- Describes the latest applications of omics technologies
- Provides an excellent reference for applications of advanced omics techniques
- Includes advanced tools and methodologies for dealing with the data generated
Analytical scientists, PhD students and technicians in control laboratories, universities, hospitals, research laboratories and regulation agencies
- Dedication
- Contributors to Volume 64
- Series Editor's Preface
- Preface
- Part I: Genomics and Transcriptomics
- Chapter 1: Applications of Functional Gene Microarrays for Profiling Microbial Communities
- Abstract
- 1 Introduction
- 2 Comparison of Microarrays with High-Throughput Sequencing
- 3 Functional Gene Arrays
- 4 Key Issues in Microarray Application
- 5 Future Advancements
- 6 Conclusions
- Acknowledgments
- Chapter 2: microRNA Profiling: An Overview of Current Technologies and Applications
- Abstract
- 1 Introduction
- 2 miRNA Biogenesis and Nomenclature
- 3 Considerations for miRNA Profiling
- 4 miRNA Extraction
- 5 qPCR Analysis of miRNAs
- 6 Microarray Profiling of miRNAs
- 7 Small RNA-seq
- 8 In Silico miRNA Analysis Resources
- 9 miRNA Functional Analysis
- 10 Recent Developments in the Application of miRNA Profiling to Cancer Research
- 11 Conclusions
- Chapter 3: Application of Novel Genotyping Microarray Technologies in Cancer Research
- Abstract
- 1 Introduction
- 2 Cancer Genetics: From Biology to Clinical Practice
- 3 Genotyping Technologies
- 4 Next-Generation Genomic Techniques
- 5 Applications of Novel SNP Technologies in Cancer Research
- 6 Conclusions and Future Directions
- Chapter 4: Applications of Next-Generation Sequencing Technologies to the Study of the Human Microbiome
- Abstract
- 1 Introduction
- 2 Next-Generation Sequencing
- 3 Bioinformatics
- 4 The Microbiome in Health and Disease
- Chapter 5: Emerging RNA-Seq Applications in Food Science
- Abstract
- 1 Introduction
- 2 Overview of RNA-Seq Technology
- 3 Applications of RNA-Seq
- 4 RNA-Seq in Food Science
- 5 Future Outlooks and Conclusions
- Acknowledgments
- Chapter 1: Applications of Functional Gene Microarrays for Profiling Microbial Communities
- Part II: Proteomics and Peptidomics
- Chapter 6: Making Progress in Plant Proteomics for Improved Food Safety
- Abstract
- 1 Introduction
- 2 Current Technologies in Plant Proteomics Sample Treatment
- 3 The Power of Hexapeptide Ligand Libraries
- 4 Examples of Plant Proteomics Studies Focusing on Low-Abundance Species
- 5 Proteomics Applications in Food Security
- 6 The Innovative Involvement of CPLL in Plant Allergen Discovery
- 7 Toward Possible New Steps
- Chapter 7: Advantages and Applications of Gel-Free Proteomic Approaches in the Study of Prokaryotes
- Abstract
- 1 Introduction
- 2 Proteomic Workflows
- 3 Affinity Chromatography Applications
- 4 Gel-Free Peptide Chromatography and Mass Spectrometry
- 5 Labeling and Label-Free Approaches for Protein Quantification
- 6 Peptide Identification
- 7 Proteomic Data Postanalysis
- 8 State of Affairs in the Study of Prokaryotes via Gel-Free Proteomics
- 9 Conclusions and Future Prospects
- Acknowledgments
- Chapter 8: Proteomics Tools for Food Fingerprints: Addressing New Food Quality and Authenticity Challenges
- Abstract
- 1 Introduction
- 2 Proteomics
- 3 Proteomics for Addressing New Food Quality and Authenticity Challenges
- 4 Innovative Protein-Based Technologies
- 5 Concluding Remarks and Future Directions
- Chapter 9: Salivary Peptidomics Targeting Clinical Applications
- Abstract
- 1 Introduction
- 2 Sample Preparation for Salivary Peptidome
- 3 Methodologies for Salivary Peptidome Analysis
- 4 Functional Relevance of Salivary Peptidome
- 5 The Missing Link: Connecting Peptides to Peptidases
- 6 Impact of Diseases in the Human Salivary Peptidome
- 7 Future Perspective
- Acknowledgments
- Chapter 6: Making Progress in Plant Proteomics for Improved Food Safety
- Part III: Metabolomics
- Chapter 10: Metabolomics in the Study of Alzheimer's Disease
- Abstract
- 1 Introduction
- 2 Metabolomics in AD
- 3 Conclusions and Future Research
- Acknowledgments
- Chapter 11: Application of Metabolomics to Cardiovascular and Renal Disease Biomarker Discovery
- Abstract
- 1 Introduction
- 2 What to Expect from the “Omics”: Changing the Perspective
- 3 Metabolomics in CVD
- 4 Metabolomics in Renal Disease
- 5 Approaching the Cardiorenal Puzzle
- 6 Microvesicles: A Novel Source of Biomarkers
- Chapter 12: The Clinical Application of Proteomics and Metabolomics in Neonatal Medicine
- Abstract
- 1 Introduction
- 2 A Brief History of Newborn Screening
- 3 Clinical Correlates: What the Physician Needs to Know at the Bedside
- 4 Beyond Newborn Screening: Additional Clinical Applications and the Potential for the Future
- 5 Initial Emerging Avenues for Fetal and Neonatal Assessment with Proteomics and Metabolomics
- 6 Tailored Drug Therapy for the Neonate
- 7 Summary
- Chapter 10: Metabolomics in the Study of Alzheimer's Disease
- Part IV: Other Omics Strategies, Data Treatment, Integration and Systems Biology
- Chapter 13: Profiling of Genetically Modified Organisms Using Omics Technologies
- Abstract
- 1 Introduction
- 2 Debated Safety Issues on GMOs
- 3 Omics Profiling in GMO Analysis
- 4 Future Outlook and Conclusions
- Acknowledgments
- Chapter 14: MS-Based Lipidomics
- Abstract
- 1 Introduction
- 2 Sample Preparation
- 3 Lipid Analysis
- 4 Identification
- 5 Data Processing for MS-Based Lipidomics
- 6 Conclusions
- Chapter 15: Foodomics: Food Science and Nutrition in the Postgenomic Era
- Abstract
- 1 Introduction to Foodomics
- 2 Omics Tools Used in Foodomics
- 3 Data Analysis and Integration: Foodomics and Systems Biology
- 4 Present Applications of Foodomics
- 5 Future Trends and Opportunities for Foodomics
- Acknowledgments
- Chapter 16: Omics Data Integration in Systems Biology: Methods and Applications
- Abstract
- 1 Introduction
- 2 Integrated Database Resources
- 3 Integrative Omics Analysis
- 4 Tools for Integrative Visualization of Omics Data
- 5 Conclusions and Future Prospects
- Acknowledgments
- Chapter 13: Profiling of Genetically Modified Organisms Using Omics Technologies
- Index
- Edition: 1
- Volume: 64
- Published: May 8, 2014
- Imprint: Elsevier
- No. of pages: 496
- Language: English
- Hardback ISBN: 9780444626509
- eBook ISBN: 9780444626691
VG
Virginia García-Cañas
AC
Alejandro Cifuentes
CS