Anti-inflammatory Agents Part II

List of Contributors

Preface

Contents of Volume I

Biological Properties and Clinical Evaluation

Chapter 1 Introduction and Background to the Regulation of Inflammation and the Immune Response

I. The Cost and Benefit of Inflammation and Its Therapy

II. Local Hormones as Inflammagens and Mediators

III. Macromolecular Mediators of Inflammation (and Repair)

IV. Cellular Mediators of Inflammation

V. Tissue Components

VI. In Retrospect

VII. Strategies for Drug Intervention

VIII. The Double Standard

IX. In Prospect

X. A Critical Appraisal of the Factors Inherent in the Testing of New Compounds

XI. Targets in Inflammatory Therapy

XII. The Clinical Evaluation of Antiarthritic Drugs

XIII. Appendix: A Brief Bibliography of Inflammation

References

Chapter 2 Evaluation for Antiinflammatory Activity

Introduction

I. Method of Assay: The Modification of One of the Cardinal Signs of Inflammation

II. Method of Assay: The Modification of One of the Events Occurring during the Inflammatory Process

III. Method of Assay: The Possession of a Property That Has Been Associated with a Class of Drugs Known to Be Antiinflammatory

IV. Method of Assay: The Modification of Syndromes Purported to Be Animal Models for Human Rheumatoid Diseases

V. Summary

References

Chapter 3 Evaluation for Immunosuppressive and Antiallergic Activity

I. Introduction

II. Site of Action

III. Laboratory Evaluation

IV. Immediate-Type (Humoral) Hypersensitivity

V. Delayed-Type (Cellular) Hypersensitivity

VI. Addendum

References

Chapter 4 Assessment of the Toxicity of Antiinflammatory Drugs

I. Introduction

II. General Considerations of Toxicological Testing

III. Assessment of Pathophysiological Responses to Drugs by Organ Systems

IV. Cytotoxic Drugs

V. Conclusion

References

Chapter 5 Evaluation for Clinical Efficacy

I. Evaluation of Antietiological Agents (for Eradicating the Prime Cause)

II. Evaluation of Drugs That May Prevent Initial Tissue Injury

III. Evaluation of Classical Antiinflammatory Agents

IV. The Different Phases of a Clinical Trial

V. Appendix

References

Chapter 6 Drug Kinetic Studies with Nonsteroidal Antiinflammatory Agents in Animals and Man

I. Introduction

II. Comparison of Indomethacin and Phenylbutazone

III. Application to Newer Clinical Agents

References

Chapter 7 Inhibition of Blood Platelet Function

I. Introduction

II. Role of Platelets in Hemostasis and Thrombosis

III. Effects of Antiinflammatory Drugs on Adhesion of Platelets to Collagen and to Glass

IV. Effects of Antiinflammatory Drugs on the Platelet Release Reaction

V. Effects of Antiinflammatory Drugs on Platelet Aggregation

VI. Effects of Antiinflammatory Drugs In Vivo

VII. Mechanisms of Action

VIII. Conclusion

References

Chapter 8 Molecular and Cellular Pharmacology of the Antiinflammatory Drugs: Some In Vitro Properties Related to Their Possible Modes of Action

I. Introduction

II. Activities Involving Protein Binding

III. Prostaglandins

IV. Effects on Cells and Membranes

V. Evaluation

VI. Appendix

References

Chapter 9 Some Effects of Antiinflammatory Drugs on Connective Tissue Metabolism

I. Brief Review of Connective Tissue Structure and Metabolism

II. Effect of Antiinflammatory Drugs on Mucopolysaccharide Metabolism

III. Effect of Antiinflammatory Drugs on Collagen Metabolism

IV. Conclusions

References

Chapter 10 Metabolism of Selected Antiinflammatory Compounds

I. Introduction

II. Aspirin

III. Phenylbutazone and Some Other Noncarboxylic Acids

IV. Indomethacin

V. Fenamic Acids

VI. Methanesulfonanilides

VII. Concluding Remarks

References

Author Index

Subject Index