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Anesthesia and Analgesia in Laboratory Animals
- 3rd Edition - May 17, 2023
- Editors: Melissa Dyson, Paulin Jirkof, Jennie Lofgren, Elizabeth Nunamaker, Daniel Pang
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 2 1 5 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 2 2 0 - 1
Anesthesia and Analgesia in Laboratory Animals focuses on the special anesthetic, analgesic and postoperative care requirements associated with experimental intervent… Read more
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Request a sales quoteAnesthesia and Analgesia in Laboratory Animals focuses on the special anesthetic, analgesic and postoperative care requirements associated with experimental interventions. Fully revised and updated, this new edition provides the reader with agents, methods and techniques for anesthesia and analgesia that ensure humane, reproducible, and successful procedural outcomes. Sections cover ethical, regulatory and scientific considerations, principles of anesthesia and analgesia, anesthetic equipment and monitoring, periprocedural care, including dedicated chapters to the assessment and management of pain in laboratory species, and practical considerations by species, including relevant anatomy, physiology, and behavior of a broad range of lab animal species.
This will be a complete reference for veterinarians involved in lab animal research as well as senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research.
- Provides researchers with the most comprehensive and up-to-date review of the use of anesthesia and analgesia in laboratory animals
- Includes complete coverage of agents' impact in research outcomes
- Thoroughly updated with new material on ferrets, birds, reptiles, amphibians, fish and cephalopods
- Covers hot topic areas such as pain research, ethical issues, legal issues and imaging studies
- Cover image
- Title page
- Table of Contents
- American College of Laboratory Animal Medicine Series
- Copyright
- Contributors
- Preface
- Abbreviations
- Section I. Ethical, regulatory, and scientific considerations
- Chapter 1. Ethics
- I. Introduction
- II. Consequentialist ethics in laboratory animal use
- III. Minimizing harms and maximizing pleasures for animals in laboratories
- IV. The Three Rs approach to minimizing harms to animals
- V. Justifying harms to animals, beyond the Three Rs
- VI. Veterinarians as anesthesia and analgesia experts and advocates: responsibilities and authority
- VII. Significant unalleviated pain and distress (Category E experiments)
- VIII. Ethics of uncertainty
- IX. Critical anthropomorphism
- X. Conclusion
- Chapter 2. Regulatory issues
- I. Introduction
- II. Regulations, standards, and policies on humane animal care in the United States
- III. Drug enforcement regulations and policies
- IV. Occupational health and safety considerations
- V. International considerations
- Chapter 3. Optimizing anesthesia and analgesia for specific research projects
- I. General implications of anesthesia and analgesia on study design
- II. Specific implications of anesthesia and analgesia on study design
- III. Conclusions
- Section II. Principles of anesthesia and analgesia
- Chapter 4. Injectable anesthetics
- I. Introduction
- II. γ-aminobutyric acid receptor agonists
- III. NMDA-antagonists
- IV. Miscellaneous agents
- V. Anesthetic combinations
- VI. Injectable anesthetic delivery systems
- Chapter 5. Tranquilizers, sedatives, local anaesthetics and antimuscarinic agents
- I. Tranquilizers and sedatives
- II. Local anesthetics
- III. Muscarinic antagonists
- IV. Conclusion
- Chapter 6. Inhalant anesthetics and safety
- I. Veterinary pharmacology of inhalation anesthetics
- II. Single circuit and multi circuit design
- III. Vaporizers
- IV. Anesthesia machines and workstations
- V. Induction chambers
- VI. Choosing inhalants for research
- VII. Waste anesthetic gas
- VIII. Summary and conclusions of waste anesthetic gas
- Chapter 7. Pharmacology of Analgesics
- I. Introduction
- II. Nonsteroidal anti-inflammatory drugs
- III. Opioids
- IV. α2-adrenergic agonists
- V. N-methyl-D-aspartate receptor antagonists
- VI. Gabapentinoids
- VII. Future prospects
- Chapter 8. Neuromuscular blocking agents
- I. Introduction
- II. Indications for use of neuromuscular blocking agents
- III. Contraindications for use of NMBA
- IV. Welfare implications of using neuromuscular blocking agents
- V. Neuromuscular junction anatomy and physiology
- VI. Mechanism of action of NMBA
- VII. Clinical use and monitoring
- VIII. Monitoring of neuromuscular function
- IX. Clinical pharmacology and use of reversal agents
- X. Future and upcoming agents
- Section III. Anesthetic equipment and monitoring
- Chapter 9. Anesthesia delivery systems
- I. Introduction
- II. Anesthesia machine
- III. Patient interface
- Chapter 10. Monitoring of anesthesia
- I. Introduction
- II. Monitoring of the anesthetized patient
- III. Special circumstances
- IV. Summary and conclusions
- Section IV. Periprocedural care
- Chapter 11. General care: periprocedural management considerations for research animals
- I. Introduction
- II. Oversight, planning, and organization
- III. Medical recordkeeping and veterinary care
- IV. Interventions for care and well-being
- V. Humane endpoint considerations
- Chapter 12. Pain assessment in laboratory species
- I. Introduction
- II. Types of pain
- III. Why prevent pain?
- IV. Pain assessment
- V. Pain assessment methods
- VI. Challenges in assessment of pain
- VII. Documentation and record-keeping
- VIII. Summary
- Chapter 13. Basic considerations for pain management in laboratory animals
- I. Rationale for pain mitigation
- II. Considerations for prescription of analgesia
- III. Nonpharmacological treatments for pain
- IV. Operational aspects of pain management
- Section V. Practical considerations by species
- Chapter 14. Anesthesia and analgesia in laboratory rodents
- I. Introduction
- II. Pre-procedural considerations
- III. Anesthesia
- IV. Historic anesthetic regimens used for special purposes
- V. Use of neuromuscular blocking agents and antagonists
- VI. Anesthesia for specific situations
- VII. Post-procedural recovery and care
- VIII. Analgesia
- Chapter 15. Anesthesia and analgesia in rabbits
- I. Introduction
- II. Preoperative considerations
- III. Anesthesia
- IV. Anesthetic circuits, monitoring and support
- V. Postoperative analgesia
- Chapter 16. Anesthesia, restraint and analgesia in laboratory fishes
- I. Introduction
- II. Preprocedural considerations
- III. Restraint
- IV. Analgesia, anesthesia and balanced anesthesia
- V. Postprocedural recovery and care
- VI. Pain and welfare assessment
- Chapter 17. Anesthesia and analgesia in laboratory pigs
- I. Introduction
- II. Preprocedural considerations and planning
- III. Sedation
- IV. General anesthesia
- V. Animal preparation
- VI. Anesthetic monitoring and support
- VII. Common anesthetic emergencies
- VIII. Postprocedural recovery and care
- IX. Analgesia
- Chapter 18. Anesthesia and analgesia in nonhuman primates
- I. Introduction
- II. Preprocedural considerations
- III. Chemical restraint
- IV. Anesthesia
- V. Analgesia
- VI. Special considerations
- VII. Responding to emergencies
- VIII. Postprocedural recovery and care
- Chapter 19. Anesthesia and analgesia in dogs and cats
- I. Introduction
- II. Preprocedural considerations
- III. Chemical restraint (sedation)
- IV. General anesthesia
- V. Anesthetic management and monitoring
- VI. Common anesthetic emergencies
- VII. Anesthesia for specific situations
- VIII. Postprocedural recovery and care
- IX. Pain assessment and analgesia
- Chapter 20. Anesthesia and analgesia in ruminants
- I. Introduction
- II. Preprocedural considerations
- III. Pain assessment and the need for analgesia
- IV. Sedation and premedication
- V. Anesthesia
- VI. Maintenance of anesthesia
- VII. Anesthesia monitoring
- VIII. Intraoperative support
- IX. Analgesia
- Chapter 21. Analgesia and anesthesia in ferrets
- I. Introduction
- II. Preprocedural considerations
- III. Chemical restraint (sedation) principles
- IV. General anesthesia principles
- V. Support and monitoring of the patient
- VI. Drugs used for sedation and anesthesia
- VII. Common anesthetic emergencies and treatment
- VIII. Postanesthetic considerations
- IX. Analgesia
- X. Anesthesia and analgesia for specific situations
- Chapter 22. Anesthesia and analgesia in other mammals
- I. Marsupialia: marsupials
- II. Scandentia and Eulipotyphla: insectivores
- III. Rodentia: nontraditional species of laboratory rodents
- V. Xenarthra: edentates (nine-banded armadillo—Dasypus novemcinctus)
- VI. Chiroptera: bats
- VIII. Prosimii: gray mouse lemur (Microcebus murinus)
- Chapter 23. Anesthesia and analgesia in birds
- I. Avian physiology and anatomy relevant to anesthesia and analgesia
- II. Preprocedural considerations
- III. Preoperative management
- IV. Anesthetic agents
- V. Anesthetic monitoring, management and emergencies
- VI. Anesthetic recovery
- VII. Analgesia
- VIII. Anesthesia for specific situations
- Chapter 24. Anesthesia and analgesia in reptiles
- I. Introduction
- II. Reptilian anatomy and physiology of anesthetic and analgesic relevance
- III. Preprocedural considerations
- IV. Chemical restraint versus anesthesia
- V. Anesthesia
- VI. Anesthesia for specific situations
- VII. Postanesthetic recovery and care
- VIII. Analgesia
- IX. Euthanasia
- Chapter 25. Anesthesia and analgesia in amphibians
- I. Introduction
- II. Anatomy and physiology relevant to anesthesia
- III. Preprocedural considerations
- IV. Chemical restraint versus anesthesia
- V. Chemical restraint
- VI. Monitoring
- VII. Analgesia
- VIII. Anesthesia and analgesia for specific situations
- IX. Postprocedural recovery and care
- X. Euthanasia
- Chapter 26. Anesthesia and analgesia in invertebrates
- I. Introduction
- II. Anesthesia
- III. Pain and analgesia in invertebrates
- IV. Euthanasia
- Section VI. Special topics
- Chapter 27. Management of chronic pain
- I. Introduction
- II. Recognition and assessment of chronic pain
- III. Treatment
- Chapter 28. Anesthesia and analgesia in the fetus and neonate
- I. Introduction
- II. Anesthesia of the dam for fetal surgery
- III. Neuraxial analgesia/anesthesia
- IV. Prevention of post-operative pre-term labor
- V. Functional maturity of key organ systems in newborn animals
- VI. Anesthesia of neonatal animals
- VII. Supportive measures during neonatal anesthesia
- VIII. Postanesthetic period
- IX. Neonatal analgesia
- Chapter 29. Anesthesia for in vivo imaging studies: practical considerations for experimental outcomes and animal welfare
- I. Introduction
- II. Imaging modalities
- III. Animal preparation and experimental planning
- IV. Management of anesthesia in imaging studies
- V. Conclusions
- Chapter 30. Preclinical pain testing: a short guide to where we are and where we are going
- I. Why the need for animal use in pain research?
- II. Animal models (assays) of pain
- III. Pain measures
- IV. Organismic and environmental factors
- V. External and internal validity
- VI. The future of preclinical pain research
- Index
- No. of pages: 788
- Language: English
- Edition: 3
- Published: May 17, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128222157
- eBook ISBN: 9780128222201
MD
Melissa Dyson
PJ
Paulin Jirkof
JL
Jennie Lofgren
EN
Elizabeth Nunamaker
DP