Analytical Biotechnology

A selection of the contents. Preface. Process Control. Monitoring and control of recombinant protein production (K. Schügerl et al.). Rapid and quantitative analysis of bioprocesses using pyrolysis mass spectrometry and neural networks: application to indole production (R. Goodacre, D.B. Kell). Characterization of a sampling unit based on tangential flow filtration for on-line bioprocess monitoring (T. Buttler, L. Gorton, G. Marko-Varga). Automated monitoring of biotechnological processes using on-line ultrafiltration and column liquid chromatography (N.C. Van de Merbel et al.). On-line monitoring of penicillin V during penicillin fermentations: a comparison of two different methods based on flow-injection analysis (M. Carlsen et al.). Development of an on-line method for the monitoring of vicinal diketones and their precursors in beer fermentation (C. Mathis et al.). Monitoring of fermentation by infrared spectrometry. Alcoholic and lactic fermentations (D. Picque et al.). Chromatography and other Separation Techniques. Chromatographic analysis of biopolymers distribution in "poly-hemoglobin", an intermolecularly crosslinked hemoglobin solution (J. Simoni, G. Simoni, M. Feola). Application of multivariate mathematical-statistical methods for the comparison of the retention behaviour of porous graphitized carbon and octadecylsilica columns (E. Forgács, T. Cserháti, B. Bordás). Antibodies. Catalytic antibodies: new developments (R. Hilhorst). Biosensors. Measurements of nitric oxide in biological materials using a porphyrinic microsensor (T. Malinski et al.). Reusable fiber-optic-based immunosensor for rapid detection of imazethapyr herbicide (R.B. Wong, N. Anis, M.E. Eldefrawi). Biosensor monitoring of blood lactate during open-heart surgery (M. Kyröläinen et al.). Instrumental Techniques. Introduction to the dielectric estimation of cellular biomass in real time, with special emphasis on measurements at high volume fractions (C.L. Davey et al.). Spectral analysis of interactions between proteins and dye ligands (J. Hubble, A.G. Mayes, R. Eisenthal). Enzymatic Analysis. Preservation of shelf life of enzyme based analytical systems using a combination of sugars, sugar alcohols and cationic polymers or zinc ions (T.D. Gibson, J.N. Hulbert, J.R. Woodward). Colloidal Carbon Particles. Colloidal carbon particles as a new label for rapid immunochemical test methods: Quantitative computer image analysis of results (A. van Amerongen et al.). Author Index.