Amphibian Models of Development and Disease
- 1st Edition, Volume 145 - May 30, 2021
- Imprint: Academic Press
- Editor: Sergei Y. Sokol
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 8 3 3 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 6 8 3 4 - 9
Amphibian Models of Development and Disease, Volume 145 in the Current Topics in Developmental Biology series, highlights new advances in the field written by an intern… Read more
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Request a sales quoteAmphibian Models of Development and Disease, Volume 145 in the Current Topics in Developmental Biology series, highlights new advances in the field written by an international board of experts. New chapters in this release include Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells, Biomechanics of Amphibian Morphogenesis, Planar cell polarity during neural tube closure, Xenopus neural crest and its relevance to human disease, Endoderm organogenesis, From egg to embryo in marsupial frogs, Evo-devo lessons from the analysis of Xenopus genomes, Transcriptional regulation during zygotic genome activation, Proteomics and metabolomics for cell lineage analysis in frog embryos, and more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Current Topics in Developmental Biology series
- Includes the latest information on Amphibian Models of Development and Disease
Clinicians in the fields of endocrinology, rheumatology, orthopedics, pediatrics and dentistry; basic scientists in anatomy, cell and developmental biology; students and postdoctoral fellows who would like to enter these fields and make further discoveries as well as improve the treatment of major bone-related disorders
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Amphibian models: Pros and cons
- Looking ahead
- Acknowledgments
- Section I: From early development to morphogenesis and tissue patterning
- Chapter One: Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells
- Abstract
- 1: Introduction
- 2: MCC specification and differentiation
- 3: Radial intercalation in the Xenopus epithelium
- 4: Conclusions
- Acknowledgments
- Chapter Two: Xenopus neural tube closure: A vertebrate model linking planar cell polarity to actomyosin contractions
- Abstract
- 1: Introduction
- 2: Mechanisms leading to PCP
- 3: PCP and actomyosin contractility
- 4: The PCP pathway in neural tube closure
- 5: Conclusions
- Acknowledgments
- Chapter Three: Modeling endoderm development and disease in Xenopus
- Abstract
- 1: Introduction
- 2: Experimental advantages of Xenopus to study endoderm development
- 3: Endoderm formation
- 4: Mouth and pharynx development
- 5: Trachea, lungs, and esophagus development
- 6: Pancreas development
- 7: Liver development
- 8: Stomach and intestinal development
- 9: Future directions
- Acknowledgments
- Chapter Four: From egg to embryo in marsupial frogs
- Abstract
- 1: Introduction
- 2: Overview of reproduction and development in marsupial frogs
- 3: Patterns of gastrulation in frogs
- 4: Multinucleated oogenesis and nurse cells
- 5: Conclusion
- Acknowledgments
- Section II: Systems biology approaches in amphibians
- Chapter Five: LIM homeodomain proteins and associated partners: Then and now
- Abstract
- 1: Introduction
- 2: History and an overview of LIM-HD genes
- 3: Molecular interactions between LIM-HD and cofactors to form a regulatory complex
- 4: Overview of the role of LIM-HD proteins in development
- 5: Conclusion
- Acknowledgements
- Chapter Six: Control of zygotic genome activation in Xenopus
- Abstract
- 1: Introduction
- 2: On the biology of zygotic genome activation
- 3: Regulation of RNA polymerase II-mediated transcription
- 4: Conclusion
- Acknowledgments
- Chapter Seven: Mass spectrometry based proteomics for developmental neurobiology in the amphibian Xenopus laevis
- Abstract
- 1: Introduction
- 2: Mass spectrometry proteomics for Xenopus
- 3: HRMS proteomics for developmental neurobiology in Xenopus
- 4: Conclusions
- Acknowledgments
- Section III: Amphibian models for regeneration and disease
- Chapter Eight: Salamanders: The molecular basis of tissue regeneration and its relevance to human disease
- Abstract
- 1: Introduction
- 2: Limb regeneration
- 3: Regeneration of neural tissue
- 4: Cancer and regeneration: Similar pathways different outputs
- 5: Aging, cellular senescence and immune system: Their influence on tissue regeneration
- 6: Modern tools for studying salamanders
- 7: Potential for translation from salamanders to humans
- 8: Conclusion and perspectives
- Chapter Nine: Xenopus as a platform for discovery of genes relevant to human disease
- Abstract
- 1: Congenital malformations
- 2: Congenital heart disease
- 3: Heterotaxy can lead to a severe form of CHD
- 4: Patient-driven gene discovery
- 5: The challenges of patient-driven gene discovery efforts
- 6: Xenopus tools to study congenital disease
- 7: Xenopus as a system to understand human disease
- 8: Conclusion
- Author conflict of interest
- Chapter Ten: Xenopus, an emerging model for studying pathologies of the neural crest
- Abstract
- 1: Introduction
- 2: General considerations about Xenopus frog embryos as models for neural crest developmental studies
- 3: Congenital disorders caused by defects in early formation of the neural crest
- 4: Congenital disorders caused by defects in neural crest EMT and migration
- 5: Conclusion
- Edition: 1
- Volume: 145
- Published: May 30, 2021
- Imprint: Academic Press
- No. of pages: 362
- Language: English
- Hardback ISBN: 9780128168332
- eBook ISBN: 9780128168349
SS
Sergei Y. Sokol
Sergei Sokol is at Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, USA.
Affiliations and expertise
Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, NY, USARead Amphibian Models of Development and Disease on ScienceDirect