Limited Offer
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Aminoff's Diagnosis of Neuromuscular Disorders
- 4th Edition - January 5, 2024
- Authors: Michael J. Aminoff, Jeffrey W. Ralph, Francis Walker
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 7 1 0 6 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 7 1 0 7 - 5
Succinct yet comprehensive, Aminoff's Diagnosis of Neuromuscular Disorders, 4th Edition, provides expert information and guidance on the clinical, electrodiagnostic, and imaging a… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteSuccinct yet comprehensive, Aminoff's Diagnosis of Neuromuscular Disorders, 4th Edition, provides expert information and guidance on the clinical, electrodiagnostic, and imaging aspects of neuromuscular disorders. Fully updated, it reflects important advances in the field, including an improved understanding of the molecular and genetic basis of neuromuscular disease, an expanded use of next-generation genetic testing, refinements in electrodiagnosis, and the use of ultrasound imaging techniques to evaluate the peripheral nervous system. In-depth discussions of disease states, as well as the evidence supporting the use of electrodiagnostic and imaging techniques, moves this reference from simply answering the question “How?” to also answering “Why?”
- Describes the range of clinical manifestations of individual neuromuscular diseases; the power and limitations of electrodiagnostic techniques as they relate to neuromuscular disorders; the place of genetic studies in the diagnosis and prognostication of these diseases; and the scope and utility of newer imaging procedures in detecting and localizing the underlying pathologic process.
- Reviews neuromuscular physiology and the pathology of major diseases.
- Provides a readable, well-illustrated synthesis of clinical and investigative techniques in diagnosing neuromuscular diseases, with concise guidance on how to conduct clinical, electrodiagnostic, and ultrasound evaluations and the
findings in various disease states.
- Covers a wide variety of electrodiagnostic and ultrasound procedures, including techniques for evaluating different individual nerves.
- Features video clips of waveforms and of ultrasound images to illustrate key concepts.
- An ideal resource for neuromuscular specialists, clinical neurologists, physiatrists, rehabilitation specialists, clinical neurophysiologists, and electromyographers, as well as trainees and those preparing for board certification in neurology, PM&R, neuromuscular medicine, clinical neurophysiology, and electrodiagnostic medicine.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
clinical neurologists and physiatrists, neuromuscular clinicians, and clinical neurophysiologists and electromyographers. It will also be an important reference source for trainees and those preparing for board certification in neurology, physiatry (physical medicine and rehabilitation), neuromuscular medicine, clinical neurophysiology, and electrodiagnostic medicine..
- Cover image
- Title page
- Copyright
- Dedication
- Preface to the Fourth Edition
- Preface to the First Edition
- Contents
- Video Contents
- PART I Introduction
- 1 Diagnosis of Neuromuscular Disorders
- DIAGNOSTIC APPROACH
- NEUROMUSCULAR SYNDROMES
- NEUROMUSCULAR INVESTIGATIONS
- REFERENCES
- 2 Biopsies and Neuromuscular Disease
- INTRODUCTION
- MUSCLE BIOPSY
- PERIPHERAL NERVE BIOPSY
- SKIN BIOPSIES
- ACKNOWLEDGMENT
- REFERENCES
- 3 Neuromuscular Imaging
- PATHOLOGY
- COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING
- NEUROMUSCULAR ULTRASOUND
- DIAGNOSTIC APPLICATIONS OF ULTRASOUND IN NEUROMUSCULAR DISEASE
- REFERENCES
- PART II Basic Aspects
- 4 Genetic Evaluation of Neuromuscular Disorders
- THE HUMAN GENOME
- MODES OF INHERITANCE
- GENETIC VARIANTS
- GENETIC TESTING
- INTERPRETING GENETIC REPORTS
- RESOLUTION OF VARIANTS OF UNCERTAIN SIGNIFICANCE
- ACKNOWLEDGMENT
- REFERENCES
- 5 Aspects of Nerve and Muscle Physiology
- ELECTRICAL ACTIVITY OF NERVE AND MUSCLE
- OTHER ASPECTS OF NERVE PHYSIOLOGY
- OTHER ASPECTS OF MUSCLE PHYSIOLOGY
- REFERENCES
- 6 Properties and Functional Organization of Motor Units
- MUSCLE COMPONENT OF MOTOR UNITS
- NEURAL INFLUENCE ON THE PROPERTIES OF MUSCLE
- NEURONAL COMPONENTS OF MOTOR UNITS
- MOTOR UNIT ACTIVITY DURING GRADATION OF MUSCLE CONTRACTION
- RECRUITMENT ORDER OF MOTOR UNITS
- MOTOR UNITS AND AGING
- REFERENCES
- 7 Electrodiagnostic Apparatus
- BASIC ELECTRICAL THEORY
- ELECTRODIAGNOSTIC SYSTEMS
- RECORDING ELECTRODES
- AMPLIFIER AND PREAMPLIFIER
- DISPLAY SYSTEMS
- NOISE
- INTERFERENCE
- STIMULATOR AND STIMULATING ELECTRODES
- SAFETY CONSIDERATIONS
- REFERENCES
- 8 General Aspects of Needle Electromyography
- ELECTRICAL ACTIVITY RECORDED FROM MUSCLE
- PRACTICAL CONSIDERATIONS
- REFERENCES
- 9 Clinical Aspects of Needle Electromyography
- EXAMINATION PROCEDURE
- DISORDERS OF MUSCLE
- NEUROPATHIC DISORDERS
- DISORDERS OF NEUROMUSCULAR TRANSMISSION
- THE FLOPPY INFANT
- IDENTIFICATION OF MUSCLES FOR CHEMODENERVATION PROCEDURES
- NEUROPHYSIOLOGIC INVESTIGATION OF THE PELVIC FLOOR
- ELECTROMYOGRAPHY OF THE LARYNX AND UPPER ESOPHAGEAL SPHINCTER
- ELECTROMYOGRAPHY OF THE EXTRAOCULAR MUSCLES
- ELECTROMYOGRAPHY OF THE DIAPHRAGM
- REFERENCES
- 10 Nerve Conduction Studies: Basic Principles and Pathologic Correlations
- PRINCIPLES AND TECHNICAL ASPECTS
- ERRORS IN THE PERFORMANCE OF NERVE CONDUCTION STUDIES
- PHYSIOLOGIC FACTORS AFFECTING NERVE CONDUCTION STUDIES
- LIMITATIONS OF CONVENTIONAL NERVE CONDUCTION STUDIES
- CORRELATION OF NEUROPHYSIOLOGIC FINDINGS WITH UNDERLYING PATHOLOGY
- CLINICAL ELECTRODIAGNOSIS OFNERVE LESIONS
- REPORTING AND INTERPRETATION OF NERVE CONDUCTION STUDIES
- REFERENCES
- 11 Quantitative and Related Techniques of Electromyography and Electroneurography
- QUANTITATIVE ASPECTS OF ELECTROMYOGRAPHY
- CONDUCTION STUDIES IN DIFFERENT POPULATIONS OF NERVE FIBERS
- ELECTRICAL IMPEDANCE MYOGRAPHY
- REFERENCES
- 12 Other Neurophysiologic Techniques for the Evaluation of Neuromuscular Disorders
- BLINK REFLEX
- F RESPONSE
- H REFLEX
- SOMATOSENSORY EVOKED POTENTIALS
- MOTOR EVOKED POTENTIALS
- INTRAOPERATIVE MONITORING OF NERVES
- TECHNIQUES FOR EVALUATING SMALL NERVE FIBERS
- IMPEDANCE ELECTROMYOGRAPHY
- REFERENCES
- 13 Evaluation of the Autonomic Nervous System
- ANATOMY OF THE AUTONOMIC NERVOUS SYSTEM
- CLINICAL FEATURES OF DYSAUTONOMIA
- STUDIES OF AUTONOMIC FUNCTION
- CAUSES OF DYSAUTONOMIA
- REFERENCES
- PART III Generalized Neuromuscular Disorders
- 14 Myopathic Disorders and Myalgia
- INTRODUCTION
- MUSCULAR DYSTROPHIES
- CONGENITAL MYOPATHIES
- DISTAL MYOPATHIES
- MYOTONIC DISORDERS
- METABOLIC MYOPATHIES
- GLYCOGENOSES
- DISORDERS OF LIPID METABOLISM
- MITOCHONDRIAL MYOPATHIES
- RHABDOMYOLYSIS
- ASYMPTOMATIC OR PAUCI-SYMPTOMATIC HyperCKemia
- PARASPINAL MYOPATHIES
- INFLAMMATORY MYOPATHIES
- RIPPLING MUSCLE DISEASE
- INFECTIOUS AND PARAINFECTIOUS MYOPATHIES
- CRITICAL ILLNESS MYOPATHY
- AMYLOID MYOPATHY
- ENDOCRINE MYOPATHIES
- MYOPATHY SECONDARY TO DRUGS OR ALCOHOL
- MYOPATHY AND MALIGNANT DISEASE
- REFERENCES
- 15 Muscle Channelopathies
- CHLORIDE CHANNELOPATHIES: MYOTONIC DISORDERS
- SODIUM CHANNELOPATHIES: DISORDERS WITH MYOTONIA, PARALYSIS, OR BOTH
- OTHER CATION CHANNELOPATHIES: PARALYTIC SYNDROMES WITHOUT MYOTONIA
- DIAGNOSIS OF NONDYSTROPHIC MYOTONIAS
- DIAGNOSIS OF PERIODIC PARALYSIS
- TREATMENT OF MUSCLE CHANNELOPATHIES
- REFERENCES
- 16 Motor Neuron Disorders
- DEFINITIONS AND OVERVIEW
- AMYOTROPHIC LATERAL SCLEROSIS
- SPINAL MUSCULAR ATROPHY
- SPINOBULBAR MUSCULAR ATROPHY (KENNEDY DISEASE)
- NONHEREDITARY CAUSES OF MOTOR NEURON DISORDERS
- REFERENCES
- 17 Muscle Fiber and Motor Unit Hyperactivity States
- DISORDERS OF MUSCLE
- DISORDERS OF PERIPHERAL NERVE
- DISORDERS OF THE SPINAL CORD, BRAINSTEM, AND CEREBRAL CORTEX
- CRAMPS
- REFERENCES
- 18 Polyneuropathy and Mononeuropathy Multiplex
- OVERVIEW
- INHERITED NEUROPATHIES
- METABOLIC DISORDERS
- NEUROPATHIES Associated With INFECTIONS
- NEUROPATHIES Associated With INFLAMMATORY PROCESSES
- VASCULITIC AND OTHER ISCHEMIC NEUROPATHIES
- TOXIC NEUROPATHIES
- MALIGNANT DISEASE
- NEUROPATHY IN CRITICALLY ILL PATIENTS
- REFERENCES
- 19 Root and Plexus Lesions
- RADICULOPATHY
- POLYRADICULOPATHY
- PLEXUS LESIONS
- REFERENCES
- 20 Neuromuscular Transmission and Its Disorders
- PHYSIOLOGY OF NEUROMUSCULAR TRANSMISSION
- ELECTROPHYSIOLOGIC EVALUATION OF NEUROMUSCULAR TRANSMISSION
- DISORDERS OF NEUROMUSCULAR TRANSMISSION
- A PRACTICAL APPROACH TO EVALUATING NEUROMUSCULAR TRANSMISSION
- REFERENCES
- PART IV Focal Neuropathies
- 21 Traumatic Neuropathy and Surgical Interventions
- MECHANISM OF INJURY
- RESPONSES OF NERVE TO INJURY
- CLASSIFICATIONS OF NERVE INJURY
- PROGNOSIS
- AXONAL REGENERATION
- ELECTRODIAGNOSTIC EVALUATION
- IMAGING ASPECTS OF TRAUMATIC NEUROPATHY
- SURGICAL AND OTHER INTERVENTIONS
- REFERENCES
- 22 Median Neuropathies
- ANATOMY OF THE MEDIAN NERVE
- ANOMALOUS INNERVATION OF THE HAND MUSCLES
- CLINICAL ASPECTS OF MEDIAN NEUROPATHIES
- ELECTROPHYSIOLOGIC STUDIES OF THE MEDIAN NERVE
- ELECTROPHYSIOLOGIC ASPECTS OF MEDIAN NEUROPATHIES
- SONOGRAPHIC STUDIES OF THE MEDIAN NERVE
- REFERENCES
- 23 Ulnar Neuropathies
- ANATOMY OF THE ULNAR NERVE
- CLINICAL ASPECTS OF ULNAR NEUROPATHIES
- ELECTROPHYSIOLOGIC STUDIES OF THE ULNAR NERVE
- ELECTROPHYSIOLOGIC ASPECTS OF ULNAR NEUROPATHIES
- ULTRASOUND IN ULNAR NEUROPATHY
- REFERENCES
- 24 Radial Neuropathies
- ANATOMY OF THE RADIAL NERVE
- CLINICAL ASPECTS OF RADIAL NEUROPATHIES
- ELECTROPHYSIOLOGIC STUDIES OF THE RADIAL NERVE
- ELECTROPHYSIOLOGIC ASPECTS OF RADIAL NEUROPATHIES
- IMAGING ASPECTS OF RADIAL NEUROPATHIES
- DIAGNOSIS OF RADIAL NEUROPATHIES
- RADIAL NEUROPATHY CASE VIGNETTE
- REFERENCES
- 25 Disturbances of Other Nerves in the Upper Extremities
- MUSCULOCUTANEOUS NERVE
- SUPRASCAPULAR NERVE
- AXILLARY NERVE
- LONG THORACIC NERVE
- REFERENCES
- 26 Fibular (Peroneal) Neuropathies
- ANATOMY OF THE FIBULAR (PERONEAL) NERVE
- CLINICAL ASPECTS OF FIBULAR NEUROPATHIES
- NEUROPHYSIOLOGIC STUDIES OF THE FIBULAR NERVE
- NEUROPHYSIOLOGIC ASPECTS OF FIBULAR NEUROPATHIES
- REFERENCES
- 27 Tibial and Sural Neuropathies
- ANATOMY OF THE TIBIAL NERVE
- CLINICAL ASPECTS OF TIBIAL NEUROPATHIES
- ELECTROPHYSIOLOGIC STUDIES OF THE TIBIAL NERVE
- ELECTROPHYSIOLOGIC ASPECTS OF TIBIAL NEUROPATHIES
- IMAGING ASPECTS OF TIBIAL NEUROPATHIES
- DIAGNOSIS OF TIBIAL NEUROPATHY
- SURAL NERVE
- REFERENCES
- 28 Sciatic Neuropathies
- ANATOMY OF THE SCIATIC NERVE
- CLINICAL ASPECTS OF SCIATIC NEUROPATHIES
- NEUROPHYSIOLOGIC STUDIES OF THE SCIATIC NERVE
- NEUROPHYSIOLOGIC ASPECTS OF SCIATIC NEUROPATHIES
- REFERENCES
- 29 Disturbances of Other Nerves in the Lower Extremities
- FEMORAL NERVE
- SAPHENOUS NERVE
- LATERAL FEMORAL CUTANEOUS NERVE
- REFERENCES
- 30 Facial Neuropathies
- ANATOMY
- CAUSES OF FACIAL NEUROPATHY
- EXAMINATION OF THE FACIAL MUSCLES AND NERVE
- BELL PALSY
- OTHER ISOLATED FACIAL PALSIES
- REFERENCES
- 31 Disturbances of Other Cranial Nerves and the Phrenic Nerve
- TRIGEMINAL NERVE
- VAGUS NERVE
- ACCESSORY NERVE
- HYPOGLOSSAL NERVE
- PHRENIC NERVE
- REFERENCES
- PART V Central Nervous System
- 32 Electrophysiologic Evaluation of Selected Aspects of the Central Nervous System
- RECORDING METHODOLOGY
- TREMOR AND RELATED PHENOMENA
- MYOCLONUS
- OTHER TYPES OF ABNORMAL MOVEMENT
- UPPER MOTOR NEURON LESIONS
- REFERENCES
- APPENDIX 1 Glossary of Terms in Neuromuscular and Electrodiagnostic Medicine and Ultrasound
- APPENDIX 2 Nerve Reference Values forUltrasonography
- APPENDIX 3 Videos
- Index
- No. of pages: 720
- Language: English
- Edition: 4
- Published: January 5, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780323871068
- eBook ISBN: 9780323871075
MA
Michael J. Aminoff
Dr. Michael J. Aminoff, Distinguished Professor Emeritus in neurology at the University of California San Francisco, is an internationally recognized neurologist, clinical investigator, and author. His published contributions led to the award of a Doctor of Science degree by the University of London in 2000. He is one of the two editors-in-chief of the four-volume Encyclopedia of the Neurological Sciences (2003; 2014) as well as one of the series editors of the multivolume Handbook of Clinical Neurology. He was editor-in-chief of the journal Muscle & Nerve from 1998 to 2007 and has served on numerous other editorial boards. He was a director of the American Board of Psychiatry and Neurology for eight years and served as board chair in 2011. In 2006, he received the Lifetime Achievement Award from the American Association of Neuromuscular & Electrodiagnostic Medicine and, in 2007, the A.B. Baker Award for Lifetime Achievement in Neurological Education from the American Academy of Neurology. In 2019 he received the Robert S. Schwab Award for outstanding contributions to research in peripheral clinical neurophysiology from the American Clinical Neurophysiology Society.
Affiliations and expertise
Distinguished Professor Emeritus in Neurology; University of California San FranciscoJR
Jeffrey W. Ralph
Dr. Jeffrey W. Ralph directs the neuromuscular medicine fellowship program at the University of California San Francisco (UCSF). He completed a neurology residency as well as fellowship training in neuromuscular medicine and clinical neurophysiology at UCSF. Dr. Ralph is an expert in the electrodiagnosis of neuromuscular diseases and in the clinical management of these diseases, especially peripheral neuropathies, and since 2004 has directed the Neuropathy Center at UCSF Medical Center. His research has addressed treatments for neuropathy caused by HIV/AIDS and muscle channelopathies.
Affiliations and expertise
Clinical Professor; Director, Neuromuscular Medicine Fellowship Program; University of California San FranciscoFW
Francis Walker
Dr. Francis O. Walker joined the faculty of Wake Forest University School of Medicine in 1984 and is currently Emeritus Professor of Neurology. He has published widely on clinical neuropharmacology, neurophysiology, and neuromuscular imaging and has helped in the training of numerous fellows and residents. He has served on several editorial boards, helped create self-assessment and certifying examinations in clinical neurophysiology, and held leadership positions in medical societies including a term as president of the American Association of Neuromuscular and Electrodiagnostic Medicine. Dr. Walker has been a pioneer in the development of ultrasound as a means of evaluating the neuromuscular system, and he is a co-editor of the book Neuromuscular Ultrasound.
Affiliations and expertise
Emeritus Professor of Neurology; Wake Forest University School of Medicine