Alzheimer's Disease
Understanding Biomarkers, Big Data, and Therapy
- 1st Edition - August 28, 2021
- Imprint: Academic Press
- Author: Ahmed Moustafa
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 3 3 4 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 3 3 5 - 3
Nearly 44 million people have Alzheimer’s or related dementia worldwide, according to the Alzheimer’s Disease International organization. That number is expected to double every 20… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteNearly 44 million people have Alzheimer’s or related dementia worldwide, according to the Alzheimer’s Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer’s and other forms of dementia.
First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer’s disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer’s disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer’s diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer’s disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer’s disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.
First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer’s disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer’s disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer’s diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer’s disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer’s disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.
- Reviews recent developments of cognitive and clinical studies
- Covers factors underlying the transition from mild cognitive impairment to Alzheimer’s disease
- Discusses different neural biomarkers underlying the development and treatment of Alzheimer’s disease
- Provides a comparison of the effectiveness of various types of treatments
Advanced students and researchers in cognitive and behavioral neuroscience, psychology, psychiatry, psychotherapy, neurology
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Acknowledgments
- Part I: Mental health in dementia
- Chapter 1. Measures of depression in Alzheimer’s disease
- Abstract
- Introduction
- Measures of depression in AD
- Discussion and conclusion
- References
- Chapter 2. The nature of depression in dementia: a narrative review
- Abstract
- Introduction: the diagnosis, prevalence, and impact of depression in dementia
- Methods
- Depression as a risk factor for dementia
- Subtypes of depression in dementia
- Depression and insight
- Depression in subtypes of dementia: relation to insight
- Conclusions and future work
- References
- Chapter 3. Stress and anxiety in dementia
- Abstract
- Dementia background
- Mental health in dementia
- Anxiety and dementia
- Stress and dementia
- Conclusions
- References
- Part II: Advanced topics in dementia research
- Chapter 4. Alzheimer’s disease in the pupil: pupillometry as a biomarker of cognitive processing in Alzheimer’s disease
- Abstract
- Introduction
- Method
- Discussion
- References
- Chapter 5. Cognitive and neural correlates of vitamin D deficiency: focus on healthy aging and Alzheimer’s disease
- Abstract
- Introduction
- Animal studies on cognitive function and vitamin D levels
- Healthy aging, dementia, and Alzheimer’s disease
- Conclusion
- Future implications
- Ethics approval and consent to participate
- Consent for publication
- Availability of data and material
- Competing interests
- Funding
- Authors’ contributions
- References
- Chapter 6. The effect of Alzheimer’s disease on the thalamus
- Abstract
- Introduction
- The effects of Alzheimer’s disease on the thalamus
- Thalamus’s link to other parts of the brain
- Prefrontal-striatal loops and the medial prefrontal cortex
- Discussion
- Future work
- Conclusion
- References
- Chapter 7. Using big data methods to understand Alzheimer’s disease
- Abstract
- Introduction
- What is Alzheimer’s disease?
- Big data methods
- Big data analysis
- Example: the Alzheimer’s Disease Neuroimaging Initiative
- Conclusion
- References
- Chapter 8. Operational aspects of deep learning solutions for Alzheimer’s disease
- Abstract
- Introduction
- Traditional Alzheimer’s CAD method trends
- Alzheimer’s in the deep learning context
- Advantages of using deep learning
- Limitations of using deep learning
- Conclusion
- References
- Part III: Treatment of dementia
- Chapter 9. Treatment of depression in Alzheimer’s disease
- Abstract
- Introduction
- Treatment
- Conclusions
- References
- Chapter 10. Developing a Vulnerability to Negative Affect in Dementia Scale (VNADS) for music interventions
- Abstract
- Introduction
- Method
- Results
- Discussion
- Funding
- Conflict of interests
- Acknowledgments
- References
- Chapter 11. Using music to improve mental health in people with dementia
- Abstract
- Introduction
- Music therapy
- Nontherapist-led music interventions
- Theories of how music therapies and interventions work
- Conclusions and future studies
- References
- Chapter 12. The efficacy of donepezil for the treatment of Alzheimer’s disease
- Abstract
- Introduction
- The effects of donepezil in Alzheimer’s disease
- Combined treatments involving donepezil
- Conclusion
- References
- Index
- Edition: 1
- Published: August 28, 2021
- Imprint: Academic Press
- No. of pages: 254
- Language: English
- Paperback ISBN: 9780128213346
- eBook ISBN: 9780128213353
AM
Ahmed Moustafa
Dr. Ahmed Moustafa is a Professor of Psychology and Computational Modeling at School of Psychology, Bond University, Gold Coast, Queensland, Australia. Prior to moving to Bond University, Ahmed was an associate professor in Psychology and Neuroscience at Marcs Institute for Brain, Behavior, and Development & School of Psychology, Western Sydney University. Ahmed is trained in computer science, psychology, neuroscience, and cognitive science. His early training took place at Cairo University in mathematics and computer science. Before joining Western Sydney University as a lab director, Ahmed spent 11 years in America working on several psychology and neuroscience projects. Ahmed conducts research on computational and neuropsychological studies of addiction, schizophrenia, Parkinson’s disease, PTSD, depression, Alzheimer’s disease. He has published over 240 papers in high-ranking journals including Science, PNAS, Journal of Neuroscience, Brain, Neuroscience and Biobehavioral Reviews, Nature (Parkinson’s disease), Neuron, among others. Ahmed has obtained grant funding from Australia, USA, Qatar, UAE, Turkey, and other countries. Ahmed has recently published ten books: (1) Computational models of brain and behavior; (2) Social Cognition in Psychosis, (3) computational Neuroscience Models of the Basal Ganglia, (4) Cognitive, Clinical, and Neural Aspects of Drug Addiction; (5) The Nature of Depression: An updated review; (6) Big data in psychiatry and neurology; (7) Alzheimer’s Disease: Understanding Biomarkers, Big Data, and Therapy. Elsevier; (8) Cognitive and Behavioral Dysfunction in Schizophrenia; (9) Female Pioneers from Ancient Egypt and the Middle East; and (10) Mental health effects of COVID-19. In the last 10 years, Ahmed has published collaboratively with 71 colleagues, has more than 510 co-authors, from 35 institutions in 14 countries. Ahmed is now Editor-in-Chief of Discover Psychology, a new journal by Springer Nature.
Affiliations and expertise
School of Psychology, Faculty of Society and Design, Bond University, Gold Coast, Queensland, AustraliaRead Alzheimer's Disease on ScienceDirect