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African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance

Part 1. Cancer Chemoresistance, Screening Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products

  • 1st Edition, Volume 111 - June 18, 2024
  • Latest edition
  • Editors: Victor Kuete, Jean-Pierre Jacquot
  • Language: English

African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cu… Read more

Description

African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products, Volume 111 offers an overview of the potential of African medicinal plants as a source of anticancer agents to overcome with an emphasis on cancer drug resistance. Based on the collected data, the book also offers a rational classification basis for the cytotoxic activity of natural products. The general knowledge of state-of-the-art of cancer drug resistance globally and the screening methods for cytotoxic agents are described.

This book clearly identifies the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle cancers and their refractory phenotypes. The book appears a unique tool for Scientists for anticancer drug discovery from the exceptional flora of Africa.

Key features

  • Provides the first of its type reference to focus on the potential of African plants as an alternative medicine to tackle cancers and their recalcitrant phenotypes
  • Analyzes the recorded data to propose a rational basis for the classification of naturally occurring cytotoxic agents
  • Clearly identifies and discusses plants and phytochemicals that could be useful in the development of new cytotoxic drugs to overcome cancer and cancer drug resistance

Readership

Research scientists, Students, Herbalists, Pharmaceutical industries, General public, University libraries

Table of contents

1. Cancer, global burden, and drug resistance
Hermann Fongang

2. Screening methods of anticancer agents from natural source
Aimé G. Fankam and Victor Kuete

3. Established anticancer agents from plants
Armel J. Seukep and Victor Kuete

4. African medicinal plants and their derivative as the source of potent anti-leukemic products: rationale classification of naturally occurring anticancer agents
Victor Kuete

5. Potential of African medicinal plants against breast cancer and resistant phenotypes
Victor Kuete

6. Fighting colorectal cancer and its drug resistance with the resources of the flora of Africa
Victor Kuete

7. African medicinal plants and their constituents can fight glioblastoma and its drug resistance
Armelle T. Mbaveng and Victor Kuete

8. Fighting melanoma and resistant phenotypes African medicinal plants and their phytoconstituents
Brice E. N. Wamba, Armelle T. Mbaveng and Victor Kuete

9. Potential of African plants and their derived phytochemicals against hepatocellular carcinoma
Victor Kuete

10. Potential of African medicinal plants and their constituents to fight prostate cancer: An overview
Victor Kuete

11. Review of the potential of African medicinal plants and their derived products against pancreatic cancer
Victor Kuete

12. Activity of African medicinal plants against cervical cancer cells
Paul Nayim, Armelle T. Mbaveng and Victor Kuete

13. African medicinal plants and their phytochemicals can be used to combat lung cancer
Victor Kuete

14. Modes and mechanisms of action of potent cytotoxic plant-derived products from the flora of Africa
Victor Kuete

Product details

  • Edition: 1
  • Latest edition
  • Volume: 111
  • Published: June 18, 2024
  • Language: English

About the editors

VK

Victor Kuete

Professor Victor Kuete is a distinguished Cameroonian scientist and Full Professor of Pharmacognosy at the University of Dschang, where he also serves as Director of the Centre for Study, Research, and Development of Natural Resources and Technologies. His career spans over two decades of groundbreaking research in natural product pharmacology, with a particular focus on African medicinal plants as sources of antimicrobial, antiviral, and anticancer agents. Kuete’s research program emphasizes the mechanisms of action of bioactive compounds, especially against multidrug-resistant (MDR) phenotypes, and has contributed significantly to the global understanding of ethnopharmacology. He has authored more than 500 scientific publications, over 120 book chapters, and several influential books, including Medicinal Plant Research in Africa (2013), Biodiversity, Natural Products and Cancer Treatment (2014), Toxicological Survey of African Medicinal Plants (2014), and African Medicinal Spices and Vegetables (2017). His more recent works, such as African Plants to Fight Bacterial Resistance (2023) and African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and Their Chemoresistance (2024–2025), further consolidate his reputation as a leading voice in pharmacognosy. Internationally, Kuete has been awarded numerous prestigious fellowships, including TWAS (2007), AUF (2008), DAAD (2009), Alexander von Humboldt (2012–2014, 2015–2018), and Tubitak (2016). These fellowships facilitated collaborations with leading scientists across Europe, Asia, and Africa, strengthening his global research network. His work has been widely cited, with over 26,000 citations and an h-index above 95, placing him among the top 100 African scientists according to the AD Scientific Index. Beyond research, Professor Kuete plays a vital role in mentorship and academic leadership, having supervised dozens of Master’s and PhD theses, many of whose graduates now hold senior academic positions across Africa. He also serves as Editor-in-Chief of Investigational Medicinal Chemistry and Pharmacology, alongside editorial roles in several international journals, reinforcing his influence in shaping the field of ethnopharmacology and drug discovery. Professor Kuete’s career exemplifies the integration of traditional African medicine with modern pharmacological science, positioning him as a global leader in the search for novel therapeutic agents to address pressing health challenges such as cancer, infectious diseases, and drug resistance.

Affiliations and expertise
Department of Biochemistry, Faculty of Sciences, University of Dschang, Dschang, Cameroon

JJ

Jean-Pierre Jacquot

Professor Jacquot has contributed to the elucidation of redox regulation in plants. Study of the thioredoxin and glutaredoxin systems and their molecular targets. His technical competence includes: plant biochemistry, genetic engineering, site directed mutagenesis, protein structure function relationship. He has 230 articles published in peer reviewed international journals. 180 accessible in Pubmed, 228 in ISI web. He has also been the Series Editor for Advances in Botanical Research (Elsevier) since 2011 and Editorial Board member of The Journal of Biological Chemistry from 2008-2013. He has been a senior member of Institut Universitaire de France since 2007 and received Gay-Lussac von Humboldt Prize Bundes Republik Deutschland Académie des sciences française, mention Biology 2009-2010. His past and present administrative duties include Member of Conseil National des Universités section 66 (2005-2007and 2011-today), Director of Structure Fédérative 4242 Ecosystèmes forestiers, Agroressources, Bioprocédés et Alimentation (EFABA) (since 2004), Director of Pôle de recherches A2F (Agronomie Agroalimentaire Forêt), Université de Lorraine (2006-2011, 2012-today) and Head of the group «Stress response and redox regulation » of UMR Interactions Arbres Microorganismes till 2012.
Affiliations and expertise
Universite Henri Poincare, Membre de L'Institut Universitaire de France, Nancy University, France

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