African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance

Part 1. Cancer Chemoresistance, Screening Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products

1st Edition, Volume 111 - June 18, 2024
Editors: Victor Kuete, Jean-Pierre Jacquot
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 9 3 3 8 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 9 3 3 9 - 9

African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cu… Read more

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African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products, Volume 111 offers an overview of the potential of African medicinal plants as a source of anticancer agents to overcome with an emphasis on cancer drug resistance. Based on the collected data, the book also offers a rational classification basis for the cytotoxic activity of natural products. The general knowledge of state-of-the-art of cancer drug resistance globally and the screening methods for cytotoxic agents are described.

This book clearly identifies the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle cancers and their refractory phenotypes. The book appears a unique tool for Scientists for anticancer drug discovery from the exceptional flora of Africa.

Cover image
Title page
Table of Contents
Series Page
Copyright
Contributors
Preface
Chapter One: Cancer, global burden, and drug resistance
Abstract
Abbreviations
1 Introduction
2 Types of cancer
3 Clinical features of cancer
4 Diagnostic of cancer
5 Treatment of cancer
6 Prevention of cancer
7 Incidence and global burden of cancer
8 Cancer drug resistance
9 Drug resistance in hematological cancer cells and cancer burdens
10 Drug resistance of carcinoma and economic burden
11 Drug resistance of other types of cancer cell lines and economic burden
12 Conclusion
References
Chapter Two: Screening methods of anticancer agents from natural source
Abstract
Abbreviations
1 Introduction
2 History of methods used in anticancer drugs screening
3 Advanced in screening methods and anticancer agents
4 Methods used in mechanistic studies of natural products as anticancer agents
5 Recommendations for appropriate screening methods
6 Conclusion
References
Chapter Three: Established anticancer agents from plants
Abstract
Abbreviations
1 Introduction
2 History of medicinal plants and cancer management
3 Insight into the mechanisms of action of anticancer phytochemicals
4 Established plant-derived anticancer drugs and phytochemicals
5 Plant-derived anticancer compounds currently in use or tested in clinical trials
6 Overcoming obstacles in the development of plant-derived anticancer agents
7 Conclusion
References
Chapter Four: African medicinal plants and their derivatives as the source of potent anti-leukemic products: Rationale classification of naturally occurring anticancer agents
Abstract
Abbreviations
1 Introduction
2 Clinical feature and classification of leukemia
3 Human leukemia cancer cell lines
4 Leukemia and drug resistance
5 Rationale basis of the classification of the cytotoxic activity of botanicals and phytochemicals on leukemia and other cancer cell lines
6 African plant extracts and their effects on MDR leukemic cell lines
7 Phytochemicals identified in African plants and their effects on MDR leukemia cell lines
8 Cytotoxicity of botanicals and phytochemicals from the flora toward other leukemia cell lines
9 Conclusion
References
Chapter Five: Potential of African medicinal plants against breast cancer and resistant phenotypes
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of breast cancer
3 Breast cancer and drug resistance
4 Human breast cancer cell lines
5 Chemotherapy of breast cancer
6 African plant extracts and their effects on MDR breast cancer cell lines
7 Phytochemicals identified in African plants with their effects on MDR breast cancer cell lines
8 Cytotoxicity of botanicals and phytochemicals from the flora towards MCF-7 cell line
9 Conclusion
References
Chapter Six: Fighting colorectal cancer and its drug resistance with the resources of the flora of Africa
Abstract
1 Introduction
2 Clinical features and classification of breast cancer
3 Colorectal cancer and drug resistance
4 Colorectal cancer cell lines
5 Chemotherapy of colorectal cancer
6 African plant extracts and their effects on MDR colorectal cancer cell lines
7 Phytochemicals identified in African plants with the effects on MDR colorectal cancer cell lines
8 Cytotoxicity of botanicals and phytochemicals from the flora on other colon cancer cell lines
9 Conclusion
References
Chapter Seven: African medicinal plants and their constituents can fight glioblastoma and its drug resistance
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of glioblastoma
3 Glioblastoma and drug resistance
4 Glioblastoma cell lines
5 Chemotherapy of glioblastoma
6 African plant extracts and their effects on MDR glioblastoma cancer cell lines
7 Phytochemicals identified in African plant with the effects on MDR glioblastoma cell lines
8 Conclusion
References
Chapter Eight: Fighting melanoma and resistant phenotypes African medicinal plants and their phytoconstituents
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of melanoma
3 Melanoma and drug resistance
4 Chemotherapy of melanoma
5 African plant extracts and the effects on melanoma cancer cell lines
6 Phytochemicals identified in African plants with their effects on melanoma cancer cell lines
7 Conclusion
References
Chapter Nine: Potential of African plants and their derived phytochemicals against hepatocellular carcinoma
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of hepatocellular carcinoma
3 Hepatocellular carcinoma and drug resistance
4 Hepatocellular carcinoma cancer cell lines
5 Chemotherapy of hepatocellular carcinoma
6 African plant extracts and their effects on MDR Hepatocarcinoma cancer cell lines
7 Phytochemicals identified in African plant with their effects on MDR Hepatocarcinoma cancer cell lines
8 Conclusion
References
Chapter Ten: Potential of African medicinal plants and their constituents to fight prostate cancer: An overview
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of prostate cancer
3 Prostate cancer and drug resistance
4 Prostate cancer cell lines
5 Chemotherapy of prostate cancer
6 African plant extracts and their effects on MDR prostate cancer cell lines
7 Phytochemicals identified in African plants with their effects on prostate cancer cell lines
8 Conclusion
References
Chapter Eleven: Review of the potential of African medicinal plants and their derived products against pancreatic cancer
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of pancreatic cancer
3 Pancreatic cancer and drug resistance
4 Pancreatic cancer cell lines
5 Chemotherapy of pancreatic cancer
6 African plant extracts and their effects on pancreatic cancer cell lines
7 Phytochemicals identified in African plants with their effects on pancreatic cancer cell lines
8 Conclusion
References
Chapter Twelve: Activity of African medicinal plants against cervical cancer cells
Abstract
Abbreviations
1 Introduction
2 Cervical cancer and drug resistance
3 Cervical cancer cell lines used to screen the potential of African medicinal plants
4 African plant extracts and their cytotoxicity on cervical cancer cell lines
5 Phytochemicals isolated from African plants and the cytotoxicity on cervical cancer cell lines
6 Modes of action of African medicinal plants and their phytoconstituents on cervical cancer cell lines
7 Conclusion
References
Chapter Thirteen: African medicinal plants and their phytochemicals can be used to combat lung cancer
Abstract
Abbreviations
1 Introduction
2 Clinical features and classification of lung cancer
3 Lung cancer and drug resistance
4 Lung cancer cell lines
5 Chemotherapy of lung cancer
6 African plant extracts and their effects on lung cancer cell lines
7 Phytochemicals identified in African plants with their effects on lung cancer cell lines
8 Conclusion
References
Chapter Fourteen: Modes and mechanisms of action of potent cytotoxic plant-derived products from the flora of Africa
Abstract
Abbreviations
1 Introduction
2 Modes of action of plant products from the flora of Africa
3 Mechanisms of actions of plant products from the flora of Africa
4 Conclusion
References

Victor Kuete

Professor Victor Kuete is a scholar scientist at the University of Dschang, Cameroon. He has been a fellow of The Third World Academy of Science (TWAS; University of Pretoria, South Africa) in 2007, the French-speaking Countries’ Organization (AUF; University of Marseille, France in 2008, The German Academic Exchange Service (DAAD; University of Mainz-Germany) in 2009, the University of Mainz-Germany (in 2010), Alexander von Humboldt fellow (University of Mainz-Germany) from 2012-2014, The Scientific and Technological Research Council of Turkey (TUBITAK; Eskisehir) in 2015. He has also been the grantee of The Alexander von Humboldt (2015-2018) and The International Foundation for Science (2008-2009; 2012-2013). His Research Program is focused on Pharmacognosy, and he mainly investigates African medicinal plants, phytochemicals isolated from medicinal plants such as terpenoids, phenolics, and alkaloids as well as synthetics, as potential antimicrobial, antiviral, and anti-cancer agents. He has a Google Scholar Hirsch index (h-index) of 84 (more than 18,000 citations; 2024) and is the author of >500 Scientific publications including several books and book chapters related to Medicinal Chemistry. Prof. Victor Kuete is the Editor-In-Chief of Investigational Medicinal Chemistry and Pharmacology, Associate Editor of the Journal of Ethnopharmacology, Section Editor of BMC Complementary and Alternative Medicine; Associate Editor of Evidenced-Based Complementary and Alternative Medicine, Editorial board member of Phytomedicine and several other journals. He has been recognized as the best Cameroon Scientist in 2022 and 2023 and is amongst the most renowned African Scientists by the AD Scientific Ranking for Scientists.

Affiliations and expertise

Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon

Jean-Pierre Jacquot

Professor Jacquot has contributed to the elucidation of redox regulation in plants. Study of the thioredoxin and glutaredoxin systems and their molecular targets. His technical competence includes: plant biochemistry, genetic engineering, site directed mutagenesis, protein structure function relationship. He has 230 articles published in peer reviewed international journals. 180 accessible in Pubmed, 228 in ISI web. He has also been the Series Editor for Advances in Botanical Research (Elsevier) since 2011 and Editorial Board member of The Journal of Biological Chemistry from 2008-2013. He has been a senior member of Institut Universitaire de France since 2007 and received Gay-Lussac von Humboldt Prize Bundes Republik Deutschland Académie des sciences française, mention Biology 2009-2010. His past and present administrative duties include Member of Conseil National des Universités section 66 (2005-2007and 2011-today), Director of Structure Fédérative 4242 Ecosystèmes forestiers, Agroressources, Bioprocédés et Alimentation (EFABA) (since 2004), Director of Pôle de recherches A2F (Agronomie Agroalimentaire Forêt), Université de Lorraine (2006-2011, 2012-today) and Head of the group «Stress response and redox regulation » of UMR Interactions Arbres Microorganismes till 2012.

Affiliations and expertise

Universite Henri Poincare, Membre de L'Institut Universitaire de France, Nancy University, France

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health