African Flora to Fight Bacterial Resistance, Part I

Standards for the Activity of Plant-Derived Products

1st Edition, Volume 106 - February 24, 2023
Editor: Victor Kuete
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 8 1 6 - 2
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 8 1 7 - 9

African Flora to Fight Bacterial Resistance, Part One: Standards for the Activity of Plant-Derived Products offers a glimpse into the potential of African medicinal plants to… Read more

African Flora to Fight Bacterial Resistance, Part I

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African Flora to Fight Bacterial Resistance, Part One: Standards for the Activity of Plant-Derived Products offers a glimpse into the potential of African medicinal plants to fight bacterial infections, with an emphasis on bacterial drug resistance. Sample chapters cover the Global Burden of bacterial infections and drug resistance, Bacterial drug resistance towards natural products, Harvesting and Processing Medicinal plants for antibacterial testing, Screening methods for antibacterial agents from plant source, Established antibacterial drugs from plants, Potential of African medicinal plants against Enterobacteria: classification of plants antibacterial agents, and much more.

Based on collected data, the book offers a rationale classification basis for the antibacterial activity of plant-based products. General knowledge of state-of-the-art of drug resistance is globally described, with the book clearly identifying the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals.

Cover image
Title page
Table of Contents
Series page
Copyright page
Contributors
Preface
Chapter One: Global burden of bacterial infections and drug resistance
Abstract
Nomenclature
1 Introduction
2 Overview of the global burden of bacterial infections
3 Nosocomial infections and drug resistance
4 Drug resistance of Mycobacteria and related burden
5 The burden of Entrerobacteriacae infections and drugs resistance
6 Helicobacter pylori and the gastric ulcer
7 The burden of Gram-positive bacterial infection and drug resistance
8 Pseudomonas infections and drug resistance
9 Gonorrheal infections and drug resistance
10 Syphilis infection and drug resistance
11 Chlamydial infections and drug resistance
12 Conclusion
References
Chapter Two: Bacterial drug resistance towards natural products
Abstract
Nomenclature
1 Introduction
2 Mechanisms of bacterial resistance
3 Molecular targets of antimicrobial, emphasis on antibacterial phytochemicals
4 Resistance to antibacterial natural products
5 Conclusion
References
Further reading
Chapter Three: Harvesting and processing medicinal plants for antibacterial testing
Abstract
Nomenclature
1 Introduction
2 Preparation of herbarium specimen for plant identification
3 Cultivation and collection of medicinal plants
4 Extraction of plants for antibacterial and other pharmacological testing
5 Isolation and characterization of antibacterials from medicinal plants
6 Quality control of medicinal plants for antibacterial screenings
7 Conclusion
References
Chapter Four: Screening methods for antibacterial agents from plant source
Abstract
Nomenclature
1 Introduction
2 History of methods used for antibacterial screenings
3 Advanced in screening methods
4 Interpreting the antibacterial activity of medicinal plants
5 Some recommendations on antibacterials screenings
6 Conclusion
References
Chapter Five: Established antibacterial drugs from plants
Abstract
Nomenclature
1 Introduction
2 Plants in medicine
3 Major groups of plant-based antibacterial compounds
4 Mechanistic studies of antibacterial phytochemicals
5 Established plant-derived antibacterial drugs and phytochemicals
6 Toxicity and safety implications of herbal medicines
7 Patented plant-derived antibacterial compounds
8 Conclusion
References
Chapter Six: Potential of African medicinal plants against Enterobacteria: Classification of plants antibacterial agents
Abstract
Nomenclature
1 Introduction
2 Enterobacteria used for the antibacterial screening of African medicinal plants
3 Rationale basis of the classification of the antibacterial activity of botanicals and phytochemicals on Enterobacteria
4 African plant extracts and their effects on MDR bacteria
5 Antibiotic modullation effect of botanical from African flora towards MDR enterobacteria
6 Role of efflux pumps inhibition on the activity of African medicinal plants and derived phytochemicals towards MDR enterobacteria
7 Conclusion
References
Chapter Seven: African plants acting on Pseudomonas aeruginosa: Cut-off points for the antipseudomonal agents from plants
Abstract
Nomenclature
1 Introduction
2 Morphology, identification, and epidemiology of Pseudomonas aeruginosa
3 Drug resistance of Pseudomonas aeruginosa
4 The role of efflux systems in bacterial drug resistance
5 Rationale classification of antipseudomonal botanicals and phytochemicals
6 Modes of action of African plants constituents acting on P. aeruginosa
7 African medicinal plant with antibiotic-potentiation effects against Pseudomonas aeruginosa strains
8 Role of efflux pumps inhibition on the activity of African medicinal plants and derived phytochemicals against Pseudomonas aeruginosa
9 Conclusion
References
Chapter Eight: Fighting Gram-positive bacteria with African medicinal plants: Cut-off values for the classification of the activity of natural products
Abstract
Nomenclature
1 Introduction
2 Features of bacterial strains used for the antibacterial screening of African medicinal plants
3 The rational basis of the classification of the antibacterial activity of botanicals and phytochemicals on Gram-positive bacteria
4 African plant extracts and their effects on MDR Gram-positive bacteria
5 Antibiotic-modulation effects of botanical from African flora towards MDR Gram-positive bacteria
6 Role efflux pumps inhibition on the activity of African medicinal plants and derived phytochemicals towards MDR Gram-positive bacteria
7 Conclusion
References
Chapter Nine: Potential of African flora to combat tuberculosis and drug resistance of Mycobacteria: Rationale classification of antimycobacterial agents from a natural source
Abstract
Nomenclature
1 Introduction
2 African flora as an established plant-based phytomedicine
3 Selection of plants species to investigate antimycobacterial activity
4 Antimycobacterial plants and phytoconstituents
5 Effect of African plants or derived products in combination with antibiotics toward resistant strains of Mycobacterium tuberculosis
6 Mechanism of action of botanicals and phytochemicals from African flora towards resistant strains of Mycobacterium tuberculosis
7 Rationale classification of antimycobacterial agents from plants
8 Conclusion
References
Chapter Ten: Anti-Helicobacter pylori activities of African medicinal plants
Abstract
Nomenclature
1 Introduction
2 Drug resistance of Helicobacter pylori
3 Helicobacter pylori strains used in the antibacterial screening of African medicinal plant and phytochemicals
4 Inhibitory potential of African plant extracts on drug-sensitive and drug-resistant strains of Helicobacter pylori strains
5 Inhibitory potential of phytochemical identified in African plant on drug-sensitive and drug-resistant strains of Helicobacter pylori strains
6 Conclusion
References
Further reading

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Victor Kuete