Advances in Virus Research

1st Edition, Volume 87 - June 25, 2013
Editors: Karl Maramorosch, Frederick A. Murphy
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 4 0 7 6 9 8 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 4 0 7 8 4 7 - 5

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virolo… Read more

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Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

Series Page

Contributors

Chapter One. Mechanisms of Reovirus Bloodstream Dissemination

1 Introduction

2 Dynamics of Reovirus Infection in the Intestine and Lung

3 Hematogenous Spread of Reovirus

4 Neural Dissemination of Reovirus

5 Function of Hematogenous and Neural Spread in Reovirus Pathogenesis

6 Unanswered Questions and Future Directions

Acknowledgments

References

Chapter Two. Molecular Biology and Epidemiology of Dianthoviruses

1 Introduction

2 Dianthoviruses

3 Economic Importance of Diseases Caused by Dianthoviruses

4 Molecular Biology of Dianthovirus

5 Transmission Studies and Epidemiology

6 Effects on Environment

7 Concluding Remarks and Perspectives

Acknowledgments

References

Chapter Three. Viral and Nonviral Elements in Potexvirus Replication and Movement and in Antiviral Responses

1 Introduction

2 Elements That Regulate Potexvirus Replication

3 Elements That Regulate Potexvirus Movement

4 Elements Involved in Antiviral Responses

5 Conclusions

Acknowledgments

References

Chapter Four. Influenza Virus Transcription and Replication

1 Introduction

2 Molecular Biology of Influenza Virus Transcription and Replication

3 Structural Elements of the Influenza Virus Transcription–Replication Machine

4 Mechanisms of Influenza Virus Transcription and Replication

5 Role of Host Cell Factors

6 Outlook

Acknowledgments

References

Chapter Five. The Molecular Biology of Ilarviruses

1 Introduction

2 Virion and Genome Structure

3 Taxonomy and Genetic Diversity

4 Genome Expression

5 CP–RNA Interaction and Genome Activation

6 Virus Movement Within and Among Plants

7 Host Responses

8 Synergy Among Ilarviruses

9 Some Conclusions and Many Questions

Acknowledgments

References

Chapter Six. Genetic Variation and HIV-Associated Neurologic Disease

1 Introduction

2 Overview of HIV-1 CNS Pathogenesis

3 Clinical Diagnoses of HIV-1 CNS Infection

4 The Evolution and Adaptation of HIV-1 and the Establishment of Molecular Diversity

5 Molecular Diversity of HIV-1 Env and Neurologic Disease

6 Genetic Diversity Within HIV-1 Tat, Vpr, and the LTR, and Its Contribution to the Onset and Severity of HIV-1-Associated Neurological System Disease

7 Sequence Variation of Specific Transcription Factor-Binding Sites Within the HIV-1 LTR and Its Correlation with Nervous System Disease

8 Host Genetic Determinants of HIV-1 Infection and CNS Disease

9 Conclusion

Acknowledgments

References

Index

Karl Maramorosch

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Affiliations and expertise

Professor, Rutgers University, New Brunswick, NJ, USA

Frederick A. Murphy

Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases” and “new and emerging zoonoses” and “the threat posed by bioterrorism.” Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology” at http://www.utmb.edu/virusimages/.

Affiliations and expertise

professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston.

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Advances in Virus Research

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Karl Maramorosch

Frederick A. Murphy