Advances in Parasitology

Chapter One. Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps

• 1. Introduction
• 2. Trypanosoma cruzi, an ‘all-wheel drive’ parasite
• 3. Diagnostic Applications for Chagas disease: Present Knowledge
• 4. Diagnostic Applications for Chagas Disease: Pending Issues
• 5. Diagnostic Applications for Chagas Disease: The Road Ahead
• 6. Concluding Remarks

Chapter Two. Host–Parasite Relationships and Life Histories of Trypanosomes in Australia

• 1. Parasite Diversity and Community Relationships
• 2. The History of Trypanosomes in Australia
• 3. Evolutionary Relationships of Australian Trypanosomes
• 4. Trypanosome Host–Parasite Interactions in Australia
• 5. Future Research

Chapter Three. The Compatibility Between Biomphalaria glabrata Snails and Schistosoma mansoni: An Increasingly Complex Puzzle

• 1. Introduction
• 2. The Genetic Determinism of the Compatibility/Incompatibility of Biomphalaria glabrata and Schistosoma mansoni
• 3. Crosses and Genetic Approaches for Identifying Compatibility/Incompatibility-Linked Loci
• 4. Use of Molecular Comparative Approaches on Compatible and Incompatible Strains of Biomphalaria glabrata to Identify Candidate Genes
• 5. Use of Molecular Comparative Approaches on Strains of Schistosoma mansoni and the Discovery of Schistosoma mansoni Polymorphic Mucins
• 6. Other Putative Effector and/or Antieffector Systems Could Play Roles in Compatibility
• 7. The Compatibility Polymorphism Can Be Explained by a Combination of Matching Phenotype Status and Virulence/Resistance Processes
• 8. A Snail's History of Interaction With a Schistosome Can Influence a Subsequent Infection
• 9. Epigenetics Appear to Make the System Even More Complex
• 10. Conclusion

Chapter Four. Targeting the Parasite to Suppress Malaria Transmission

• 1. Background
• 2. The Parasite Life Cycle
• 3. Important Lessons Learnt From Previous Control Efforts
• 4. Transmission-Blocking Antiparasitic Drugs
• 5. Transmission-Blocking Antiparasitic Vaccines
• 6. Genetically Modified Mosquitoes
• 7. Paratransgenic Delivery Systems
• 8. How Do We Analyse the Impact of Transmission Blocking Interventions?

Chapter Five. The Role of Spatial Statistics in the Control and Elimination of Neglected Tropical Diseases in Sub-Saharan Africa: A Focus on Human African Trypanosomiasis, Schistosomiasis and Lymphatic Filariasis

• 1. Introduction
• 2. Overview of Neglected Tropical Diseases
• 3. Statistical Methods for Disease Risk Mapping
• 4. Common Issues in Spatial Analysis
• 5. Sources of Spatially Referenced Data
• 6. Conclusions

Chapter Six. Is Predominant Clonal Evolution a Common Evolutionary Adaptation to Parasitism in Pathogenic Parasitic Protozoa, Fungi, Bacteria, and Viruses?

• 1. Introduction
• 2. The Model of Predominant Clonal Evolution and Its Last Developments
• 3. Evidence for Predominant Clonal Evolution Features in Various Kinds of Micropathogens
• 4. The ‘Starving Sex’ Hypothesis
• 5. A debate in the debate: unisex/selfing/inbreeding versus ‘strict’ clonality
• 6. How can clones survive without recombination?
• 7. Meiosis genes and experimental evolution: what do they tell us about predominant clonal evolution?
• 8. Is predominant clonal evolution an ancestral or convergent character?
• 9. Can predominant clonal evolution features be explained by natural selection? In-built mechanisms favouring clonality
• 10. Identical multilocus genotypes are a relative notion: implications for the semiclonal/epidemic clonality model
• 11. Genomics and the predominant clonal evolution model
• 12. Relevance of the predominant clonal evolution model for taxonomy and applied research
• 13. Conclusion