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Advances in Microbial Physiology

1st Edition - April 21, 2022

Editors: Robert K. Poole, David J. Kelly

Hardback ISBN:

9 7 8 - 0 - 3 2 3 - 9 8 8 6 9 - 8

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 8 8 7 0 - 4

Advances in Microbial Physiology, Volume 150 in this important serial, highlights new advances in the field with this new volume including content by an international board of… Read more

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Advances in Microbial Physiology, Volume 150 in this important serial, highlights new advances in the field with this new volume including content by an international board of authors. Chapters in this new release include Organization of respiratory chains in the bacterial cell, Anaerobic methane oxidizing archaea, Dawn of the DedA: the structure and function of the DedA family of integral membrane proteins associated with bacterial viability and antimicrobial resistance, Nickel, an essential virulence determinant of Helicobacter pylori: trafficking pathways and their targeting by bismuth, Dissimilatory sulfur compounds oxidation in thermophilic and chemolithoautotrophic bacteria belonging to the Aquificales order, and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Nickel, an essential virulence determinant of Helicobacter pylori: Transport and trafficking pathways and their targeting by bismuth
Abstract
1: Introduction
2: A handful of nickel-dependent enzymes
3: Nickel, a virulence determinant in H. pylori
4: The H. pylori urease
5: The [NiFe] hydrogenase and the crosstalk between the hydrogenase and urease maturation machineries
6: Nickel uptake in H. pylori
7: Mechanism of nickel efflux in H. pylori
8: H. pylori nickel chaperones and storage proteins
9: Acquisition during evolution of nickel related proteins by gastric Helicobacter species
10: Regulation of nickel transport and trafficking in H. pylori
11: The metal bismuth, a component of a treatment against H. pylori infection
12: Conclusions and perspectives
Acknowledgments
References
Chapter Two: Neisseria gonorrhoeae physiology and pathogenesis
Abstract
1: Introduction
2: Pathogenesis
3: Physiology
4: Conclusions and outlook
References
Chapter Three: Defenses of multidrug resistant pathogens against reactive nitrogen species produced in infected hosts
Abstract
1: Introduction
2: Pathogens are exposed to reactive nitrogen species in infected hosts
3: Bacterial targets of RNS and responses
4: Defenses of major human pathogens against RNS
5: Effect of nitrosative stress analyzed by whole genome and proteomic approaches
6: Conclusions and future perspectives
Acknowledgments
References
Chapter Four: Metabolic potential of anaerobic methane oxidizing archaea for a broad spectrum of electron acceptors
Abstract
1: Introduction
2: Metabolic flexibility of anaerobic methanotrophic archaea
3: Possible mechanisms of electron acceptor reduction
4: Environmental implications and potential application
5: Knowledge gaps and future work
Acknowledgments
References
Chapter Five: How Streptomyces thrive: Advancing our understanding of classical development and uncovering new behaviors
Abstract
1: Introduction
2: Classical Streptomyces development
3: Alternative developmental strategies and behaviors
4: Volatile emissions: Environmental and behavioral impacts
5: Phage defense strategies of Streptomyces
6: Conclusions
References

Robert K. Poole

Professor Robert Poole is West Riding Professor of Microbiology at the University of Sheffield. He has >35 years’ experience of bacterial physiology and bioenergetics, in particular O2-, CO- and NO-reactive proteins, and has published >300 papers (h=48, 2013). He was Chairman of the Plant and Microbial Sciences Committee of the UK Biotechnology and Biological Sciences Research Council and has held numerous grants from BBSRC, the Wellcome and Leverhulme Trusts and the EC. He coordinates an international SysMO systems biology consortium. He published pioneering studies of bacterial oxidases and globins and discovered the bacterial flavohaemoglobin gene (hmp) and its function in NO detoxification He recently published the first systems analyses of responses of bacteria to novel carbon monoxide-releasing molecules (CORMs) and is a world leader in NO, CO and CORM research.

Affiliations and expertise

West Riding Professor of Microbiology, Department of Molecular Biology and Biotechnology, University of Sheffield, UK

David J. Kelly

Professor David Kelly is Emeritus Professor of Microbial Physiology at the University of Sheffield. He has >35 years research expertise in bacterial physiology and biochemistry, membrane protein transport processes and bioenergetics, and has worked with the zoonotic food-borne pathogen Campylobacter jejuni for >25 years. His laboratory has been engaged in a major program to study C. jejuni physiology, in particular the responses to oxygen, many aspects of carbon metabolism and functional analysis of the electron transport chains. He has long-standing interests in membrane transport mechanisms and in the 1990s discovered an entirely new class of periplasmic binding-protein dependent prokaryotic solute transporters, the TRAP transporters, now known to be common in a diverse range of bacteria and archaea. He has published >150 papers (h=42, 2021), held numerous grants, served on grant committees and has been a regular invited speaker at national and international conferences.

Affiliations and expertise

Professor of Microbiology, Department of Molecular Biology and Biotechnology, University of Sheffield, UK