Advances in Metabolic Disorders

Contributors

Prologue to International Studies in the Epidemiology of Diabetes

International Studies in the Epidemiology of Diabetes

Comparison of Diabetes Prevalence Rates in Oxford (1946) and Sudbury (1964)

I. Introduction

II. Materials and Methods

III. Results

IV. Discussion

V. Summary

References

The Incidence of Diabetes Mellitus in Rochester, Minnesota, 1945-1969

I. Introduction

II. Background

III. Methods

IV. Results

V. Discussion

References

Diabetes in American Indians

I. Introduction

II. The Tribes

III. Previous Rarity of Diabetes

IV. The Massive Epidemic

V. Statistics of the Indian Health Service

VI. Special Features in Diabetes

VII. Etiology

VIII. Summary

References

Incidence of Diabetes Among the Pima Indians

I. Introduction

II. Methods

III. Results and Discussion

IV. Summary

References

Blood Sugar and Serum Insulin Levels in Jamaica, West Indies

I. Introduction

II. The Population Sample

III. Methods

IV. Results

V. Discussion

VI. Subsequent Studies

VII. Summary

References

Variations in Incidence of Diabetes Among 10,000 Adult Israeli Males and the Factors Related to their Development

I. Materials and Methods

II. Results

III. Discussion

Appendix: The Variables Examined

References

Epidemiology of Diabetes in South Africa

I. The Peoples of South Africa

II. Early Reports from Natal

III. Studies in the Transvaal

IV. Definitive Studies in Natal

V. Cape Town Studies

VI. Some Comparisons and Discussion

VII. Further Findings and Analyses

VIII. Metabolic Considerations

IX. Some Conclusions

References

Prevalence of Diabetes in India

I. Introduction

II. Materials and Methods

III. Results and Discussion

IV. Summary

References

Vascular Complications in Diabetes in Japan

I. Introduction

II. Frequency and Clinical Features of Diabetes Mellitus in Japan

III. Causes of Death in Diabetic Patients

IV. Vascular Complications in Diabetic Patients: Clinical Observations

V. Summary

References

Editor's Comment

Preliminary Studies of the Prevalence and Mortality of Diabetes Mellitus in Japanese in Japan and on the Island of Hawaii

I. Introduction

II. Prevalence of Diabetes Mellitus in Japanese in Hiroshima and on the Island of Hawaii

III. Mortality of Diabetes Mellitus in Japanese and Caucasians on the Island of Hawaii and Japanese in Japan

IV. Discussion

V. Summary

References

The High Prevalence of Diabetes Mellitus in Nauru, a Central Pacific Island

I. Introduction

II. Epidemiology of Diabetes in the Pacific Region

III. The Present Study

IV. Results

V. Comments and Conclusions

References

The Relationships of Diabetes, Blood Lipids, and Uric Acid Levels in Polynesians

I. Introduction

II. Screening Methods

III. Results from the 1962-1965 Studies: Low-Risk and High-Risk Population Samples in the Pacific

IV. New Zealand Maori Studies—1968-1969 and 1974

V. Tokelau Island Migrant Study

VI. Body Mass and Diabetes in New Zealand Maori and Tokelauans

VII. Diabetes in the Kingdom of Tonga—1973 Survey

VIII. Discussion

IX. The Pacific Needs

References

HLA Studies in Diabetes Mellitus: A Review

I. Introduction

II. HLA and Disease Association Studies

III. HLA and Insulin-Dependent Diabetes Mellitus

IV. Possible Clinical Implications of the HLA-IDDM Association

V. Mechanism of the HLA-IDDM Association

VI. HLA and the Other Types of Diabetes Mellitus

VII. Summary and Conclusions

References

Epilogue

Text

The Central Nervous System, Pancreatic Hormones, Feeding, and Obesity

I. Introduction

II. Pancreatic Hormone Secretion

III. Innervation of the Islets of Langerhans

IV. Neural Regulation of Pancreatic Hormone Secretion

V. Ventral Hypothalamus: Central Control of Glucose Regulation

VI. Ventral Hypothalamus: Central Regulation of Feeding

VII. Body Weight Set Point

VIII. Insulin and Body Weight

IX. CSF Insulin and Body Weight: A Theory

References

The Role of Insulin Resistance in the Pathogenesis of Diabetes Mellitus

I. Introduction

II. Measurement of Plasma Insulin Concentrations in Patients with Diabetes Mellitus

III. Insulin Action in Vivo

IV. Insulin Action in Vitro

V. Summary

References

The Pancreas in Idiopathic Diabetes

I. Introduction

II. Gross Pancreatic Alterations

III. Hyalinization of the Pancreatic Islets

IV. Vascular Lesions

V. Pancreatic Fibrosis

VI. Fatty Atrophy

VII. Vacuolization ("Hydropic Degeneration") of the B Cells

VIII. Hypertrophy of the Islets

IX. Inflammatory Lesions of the Islets

X. Regeneration and Ductal Proliferation

XI. Fat Deposits in B Cells

XII. Degranulation of B Cells

XIII. Quantitative Changes of the Islets of Langerhans

XIV. Estimation of Islet Volume

XV. Differential Counts of the Islets of Langerhans

XVI. Quantitative Estimation of Islet Tissue

XVII. Pathogenetic Considerations of Idiopathic Diabetes

References

Somatostatin

I. Introduction

II. Isolation and Characterization

III. Localization and Action

IV. Mode of Action

V. Clinical Applications

VI. Analogs of Somatostatin

VII. Side Effects and Toxicity of Somatostatin

VIII. Conclusions

References

Dental Maturity as a Measure of Somatic Development in Children

I. Introduction

II. The Eruption Curve of the Permanent Teeth

III. Correlation between Height Development and Dental Maturity in Healthy Girls

IV. Correlation between Dental Development and Sexual Maturation in Normal Girls

V. Correlation between Somatomedin A in Serum, Dental Maturity, and Height Development

VI. Genetic Regulation of Dental Maturity and Height Development

VII. Clinical Application of the Tooth Eruption Curve of the Permanent Teeth

VIII. Conclusions

Appendix

References

Subject Index

Contents of Previous Volumes