Advances in Immunology
- 1st Edition, Volume 148 - November 12, 2020
- Imprint: Academic Press
- Editor: Frederick W. Alt
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 7 4 2 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 7 4 3 - 7
Advances in Immunology, Volume 148 offers the latest release in a long-established and highly respected publication, presenting current developments and comprehensive review… Read more
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Request a sales quoteAdvances in Immunology, Volume 148 offers the latest release in a long-established and highly respected publication, presenting current developments and comprehensive reviews in immunology. Sections in this new volume include chapters on histone deacetylases as targets in autoimmune and autoinflammatory diseases, the role of NK cell as central communicators in cancer immunity, and the mechanism and regulation of class switch recombination by transcriptional control element.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding, respected serial on the subject matter
- Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies
Immunologists and infectious disease specialists, cell biologists and hematologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Preserving immune homeostasis with A20
- Abstract
- 1: Introduction
- 2: A20 and human disease
- 3: Cell autonomous roles of A20
- 4: A20, Ubiquitin, and immune signaling
- 5: Physiological integration of A20 functions
- 6: Regulation of A20
- 7: A20 binding partners
- 8: Future directions
- Chapter Two: Unexplored horizons of cDC1 in immunity and tolerance
- Abstract
- 1: Introduction
- 2: Molecules required for human cDC1 development
- 3: C type lectins
- 4: C type lectin receptors
- 5: Chemokine receptor
- 6: Nectin and the nectin-like molecule (Necl) superfamily
- 7: Cytokine dependent hematopoietic cell linker (CLNK)
- 8: Nucleic acid sensor and nucleotide receptors
- 9: Indoleamine-2,3-dioxygenase
- 10: SERPINB9
- 11: Immunostimulatory or regulatory receptors and ligands
- 12: Check point inhibitors
- 13: Molecules associated with antigen presentation
- 14: Toll like receptors
- 15: Molecules upregulated after DC activation: Cytokines and chemokines
- 16: cDC1 and lymphocyte interaction
- 17: Conclusion
- Chapter Three: IgE and mast cells: The endogenous adjuvant
- Abstract
- 1: Overview
- 2: Biology of mast cells and IgE
- 3: Mast cell activation pathways
- 4: Immunomodulatory functions of mast cells
- 5: Mast cells and IgE in food allergy
- 6: Immunomodulatory roles of IgE antibodies and mast cells
- 7: Silencing of the IgE: mast cell axis to restore immune homeostasis
- 8: Summary and conclusions
- Acknowledgment
- Edition: 1
- Volume: 148
- Published: November 12, 2020
- Imprint: Academic Press
- No. of pages: 160
- Language: English
- Hardback ISBN: 9780128207420
- eBook ISBN: 9780128207437
FA
Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USARead Advances in Immunology on ScienceDirect