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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wi… Read more
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Series Page
Contributors
Chapter One. The Interdisciplinary Science of T-cell Recognition
1 Introduction
2 The First Level of Complexity: The Kinetics and Structural Basis of TCR–pMHC Engagement
3 The Second Level of Complexity: The TCR–CD3 Complex and Approaches to Answers of How It Works
4 The Third Level of Complexity: Antigen Recognition and the Immunological Synapse
5 Perspective
Acknowledgments
References
Chapter Two. Residual Immune Dysregulation Syndrome in Treated HIV infection
1 The Role of Activation and Inflammation in the Natural History of Infection
2 Inflammatory and Coagulation Indices Predict Morbidity in Treated HIV Infection
3 Persistent CD4 + T Cell Lymphopenia Predicts Clinical Outcomes During ART
4 Immune Activation/Inflammation Predicts Morbidity and Mortality During ART
5 Failure to Restore Circulating CD4 + T Cells in HIV Infection
6 The LN in Treated HIV Infection
7 The Gut in Treated HIV Infection
8 Other Possible Drivers of Residual Immune Dysregulation in Treated HIV Infection
9 Therapeutic Approaches
10 Summary
Acknowledgment
References
Chapter Three. Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells
1 Introduction
2 Stability and Plasticity of Regulatory T Cells
3 A Transient Flexibility Model for Regulatory T Cell Plasticity
4 Differences in Foxp3/FOXP3 Between Mice and Humans
5 Significance and Future Directions
Acknowledgments
References
Chapter Four. Logic of the Inflammation-Associated Transcriptional Response
1 Dynamic of Inflammatory Gene Expression—Bursts and Noise
2 Control of Inflammation by RNA Elongation
3 Pharmacological Targeting of RNA Elongation by BET Antagonists
4 Targeting of Inflammation by Pathogen-Derived Chromatin Modifiers
5 Concluding Remarks
References
Chapter Five. Structural Basis of Signal Transduction in the TNF Receptor Superfamily
1 Introduction
2 NF-κB Activation
3 TNFR1 and Fas-Induced Apoptosis
4 TNFR1-Induced Programmed Necrosis
5 Conclusions
Acknowledgment
References
Index
Contents of Recent Volumes
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