Advances in Antiparasitic Therapies and Drug Delivery

1st Edition - November 21, 2023
Editors: Prashant Kesharwani, Neelima Gupta
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 1 7 8 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 1 7 9 - 8

Advances in Antiparasitic Therapies and Drug Delivery systematically discusses the fundamentals, principles, and methods of molecular mixing and reaction process intensifi… Read more

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Advances in Antiparasitic Therapies and Drug Delivery systematically discusses the fundamentals, principles, and methods of molecular mixing and reaction process intensification. The book demonstrates, in detail, the implementation approach, process, and effectiveness of Higee chemical reaction engineering through novel industrial case studies that help industrial technicians to select reaction intensification technology route more scientifically. Sections cover the innovation and development process of Higee chemical reaction engineering, hydrodynamics behavior in Higee reactors, equipment design principles and methods, multiphase reaction of liquid-liquid, gas-liquid, gas-solid, gas-liquid-solid and reactive crystallization process intensification principles and effectiveness.

The book is a systematic summary of several national award and key projects, such as the State Technological Innovation Award, State Science and Technology Advancement Award, National Natural Science Foundation of China, National key R&D Program of China, National ‘‘863’’ Program of China, National ‘‘973’’ Program of China and also some international cooperation.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. An introduction to the pathophysiology of parasitic infection
Abstract
Introduction
Parasitic infections
Conclusion
Acknowledgment
Declarations of Interest
Funding
References
Chapter 2. Traditional medicine and natural products as antiparasitic agents
Abstract
Abbreviation
Introduction
Human parasitic diseases
Alkaloids
Essential oils
Quinones
Phenolics
Terpenes
Green nanoparticles as antiparasitic agents
Conclusion
References
Chapter 3. Antiparasitic drugs: a definition and scope
Abstract
Introduction
Antiprotozoal agents
Antihelminthic agents
Ectoparasiticides
References
Chapter 4. Ectoparasitic and endoparasitic drug delivery approaches for therapy
Abstract
Introduction
Chiggers
Bed bugs
Lice
Scabies
Demodex
Controlled drug delivery systems
Hydrogel
Microspheres
Microemulsion
Nanoemulgel
Discussion and conclusion
References
Chapter 5. Microneedles in antiparasitic drug delivery applications
Abstract
Introduction
Overview of antiparasitic drugs and challenges
Discussion and conclusion
References
Chapter 6. Nanotechnology: an approach to faster diagnosis of parasitic infections
Abstract
Introduction
Ectoparasites
Helminth parasites
Protozoan parasite
Correlation of nanotechnology and parasitic-induced diseases diagnosis: current and future perspectives
Conclusion
Acknowledgment
Declarations of Interest
Funding
Author Contributions
Reference
Chapter 7. Nanomedicine for parasitic helminth infections
Abstract
Abbreviations
Introduction
A brief overview through helminth and parasitic worms
Anthelmintic/nanotechnology and nanomedicine
Conclusion
References
Chapter 8. Pathogenesis, treatments, and challenges associated with malaria and nanomedicines for antimalarial therapy
Abstract
Abbreviations
Introduction
Pathogenesis of malaria
Current treatment options for malaria
Challenges in malaria management
Nanomedicines for antimalarial therapy
Conclusion
References
Chapter 9. Repurposing antiparasitic drugs for the treatment of other diseases
Abstract
Introduction
Search methods
Antiparasitic drug; kinds of pharmacological aspect
Evidences of antiparasitic drugs in the treatment of inflammatory disease
Conclusion
References
Chapter 10. Marketed antiparasitic nanotechnology-based products and drawbacks
Abstract
Abbreviations
Introduction
Method of research
Nanotechnology-based products
Fungizone
Abelcet
AmBisome
Amphotec
Challenges of antiparasitic products based on nanotechnology
Regulatory concerns
Developmental and manufacturing cost
Scale-up issues
Conclusion
Acknowledgment
Funding
Declarations of interest
References
Chapter 11. Fighting parasites during the post-antibiotic era
Abstract
Introduction
Method of research
Antibiotic therapy of parasitic infections
Novel treatments of parasitic infections post-antibiotics
Conclusion and future perspectives
Funding
References
Chapter 12. Antimicrobial resistance and recent advancement to combat parasitic infections; development of resistance to antihelminthic/antiprotozoal and antimalarial drugs
Abstract
Antiparasitic control agents
Development of resistance in Plasmodium falciparum
Antiparasitic agents for amebiasis and other parasites
Chemotherapeutic agents against Leishmaniasis
Resistance against antiparasitic agents in other parasites
Chemotherapeutic agents against trypanosomes (Table 12.5)
The emergence of resistance toward antiparasitic agents
Selection pressure of the drug
Factors related to antiparasitic agents
Ecological and geographical factors
Drug pressure
Refugia parasites
Competition or fitness
Evading the action of the drugs
Measures to combat antiparasitic resistance
References
Chapter 13. Aptamers as an emerging concept for the management of parasitic diseases
Abstract
Introduction
SELEX technology
Increasing efficacy of the aptamers
Applications of aptamers
Aptamers targeting Plasmodium spp
Aptamers targeting Cryptosporidium parvuum
References
Chapter 14. Where do we stand? Insight on patented products and those under clinical trials
Abstract
Introduction
Search methods
Novel antiparasitic drug properties
Recent clinical trial on antiparasitics drugs
Recent FDA-approved drugs; what are their features?
Consideration of future antiparasitic drugs
Conclusion
References
Chapter 15. Challenges and opportunities in antiparasitic drug discovery and delivery
Abstract
Introduction
Discussion and conclusion
References
Chapter 16. The future of antiparasitic therapy
Abstract
Introduction
Parasites and human health
Antiparasitic drugs
Improving healthcare through antiparasitic therapy
Role of clinician in drug therapy
References
Index

Prashant Kesharwani

Dr. Prashant Kesharwani is an assistant professor of pharmaceutics at School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 300 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Neelima Gupta

Prof. Neelima Gupta presently works as a vice chancellor of Dr. Harisingh Gour Vishwavidyalaya Sagar (A Central University), Madhya Pradesh, India. She is a global leader having visited the five continents of the world, including countries like the United States, UK, Japan, Germany, France, Poland, Hong Kong, Thailand, Egypt, China, Singapore, Egypt, and Australia. She is the recipient of more than 70 awards and has published 216 research papers, is the author/editor of 9 books, and has adjudicated more than 150 PhD theses in India and abroad. She has worked extensively on parasite taxonomy, aquatic toxicology, and pollution load of the Ramganga (Kalagarh to Kannauj) and Ganga (Haridwar to Kanpur) rivers, and fish health. Research contributions include morpho-molecular–SEM taxonomy and protein profile based on 60 species of 22 genera (51 new species, 3 subspecies), and 7 GenBank submissions (GenBank: NIH genetic sequence database). She is a pioneer in the Atmanirbhar Bharat Movement launched by the Government of India.

Affiliations and expertise

Vice Chancellor, Dr. Harisingh Gour Sagar University (A Central University), Sagar, Madhya Pradesh, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health