Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A

1st Edition, Volume 184 - November 6, 2021
Imprint: Academic Press
Editors: Rajesh S. Bhosale, Vijai Singh
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 3 9 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 4 0 - 8

Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A Volume 184, highlights many aspects of AIE materials that can he… Read more

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Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A Volume 184, highlights many aspects of AIE materials that can help future investigators, researchers, students and stakeholders perform research with ease. Emitting light is a fascinating photophysical phenomenon, its different forms have brought the attention of various disciplines of natural sciences for centuries. In the modern era of scientific generation, short-lived fluorescence light and its long-lived counterpart phosphorescence light has been employed for several chemo-sensing, bio-sensing, and bioimaging applications. The aggregation induced emission (AIE) phenomenon has appeared as a wand of modern science to convert aggregation-caused quenching (ACQ) materials into AIE active materials for a wide range of biomedical applications including biosensing, bioimaging and localization of molecules for better understanding of molecular mechanisms. This volume covers a wide range of topics which are not currently available in a single volume, including ACQ & AIE concept development; intracellular pH, temperature and viscosity sensing; imaging of cell membrane, lipid droplet, lysosome, and mitochondria; biosensing and Imaging of bacteria; nucleus and nucleic acid imaging.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Introduction to aggregation induced emission (AIE) materials
Abstract
1: Introduction
2: Conceptual aspects ACQ and AIE
3: Design principal of AIE molecules
4: AIE active molecules for biomedical applications
5: Conclusion and future prospects
References
Chapter Two: Aggregation induced emission (AIE) molecules for measurement of intracellular temperature, pH, and viscosity sensing
Abstract
1: Introduction
2: Application of AIE molecules for intracellular temperature sensing
3: Application of AIE active molecules for pH sensing
4: AIE active molecules for viscosity sensing
5: Conclusion
Acknowledgments
References
Chapter Three: Advances in aggregation induced emission (AIE) materials in biosensing and imaging of bacteria
Abstract
1: Introduction
2: Aggregation induced materials
3: Photodynamic inactivation
4: Natural biocompatible AIE materials
5: Applications in biosensing
6: Potential application of AIEgens in imaging and killing of bacteria
7: Toxicology aspects of AIEgens
8: Future perspectives
Acknowledgments
References
Chapter Four: Aggregation-induced emission materials for cell membrane imaging
Abstract
Graphical abstract
1: Introduction
2: Difficulties in using traditional fluorescent sensors
3: Aggregation-induced emission (AIE) phenomenon
4: Mechanism of aggregation induced emission (AIE) effect
5: Examples of cell membrane imaging
6: Conclusion
7: Future scope
References
Chapter Five: Aggregation-induced emission luminogens for lipid droplet imaging
Abstract
Graphical abstract
1: Introduction
2: Significance of lipid drops study in different organisms
3: Biosynthesis of lipid drops
4: Advancement and challenges in lipid research
5: Recent progress of lipid-specific probes with aggregation-induced emission
6: Conclusions
7: Future remarks
Acknowledgments
References
Chapter Six: AIE materials for lysosome imaging
Abstract
1: Introduction
2: Lysosome viscosity tracing probes
3: Lysosome imaging for detection of other analytes
4: Conclusions
Acknowledgment
References
Chapter Seven: Aggregation induced emission (AIE) materials for mitochondria imaging
Abstract
1: Introduction
2: Tetraphenylethene based AIEgens
3: TPA derivatives for the mitochondria detecting
4: Miscellaneous AIEgens probe for mitochondria imaging
5: Future prospectus
Acknowledgments
References
Chapter Eight: AIE materials for nucleus imaging
Abstract
1: Introduction
2: AIEgens for nucleus imaging
3: Conclusion and future prospects
Acknowledgments
References
Chapter Nine: Aggregation induced emission molecules for detection of nucleic acids
Abstract
1: Introduction
2: Mechanism of action of AIE molecules for nucleic acids detection AIE for DNA detection
3: AIE for RNA detection
4: Conclusion and future perspectives
Acknowledgment
References
Index

Rajesh S. Bhosale

Dr. Rajesh S. Bhosale is an Associate Professor at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He did his PhD (2009) from University of Geneva (Switzerland) under the supervision of Prof. Stefan Matile. Thereafter, he did first post-doctoral research as SNSF postdoctoral fellow from top institutes of World i.e. MIT-Massachusetts Institute of Technology, Cambridge, USA in the group of Prof. Timothy M. Swager and second post-doctoral research as DFG postdoctoral fellow from FRIAS-Freiburg Institute for Advanced Studies, Germany in the group of Prof. Aurelio Mateo-alonso. Where he was excelled in challenging multistep chemical synthesis, electrochemical, photophysical and self-assembly properties study of small molecules, macromolecules and polymer chromophoric systems. He also served as RMIT research associate in the group of Prof. M. Lakshmi Kantam at CSIR-IICT, Hyderabad and in July 2015 he becomes a CSIR scientist pool officer. His research interests are focused on building AIE active novel molecules.

Affiliations and expertise

Associate Professor, Department of Chemistry, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

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