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Advanced Free Radical Reactions for Organic Synthesis
1st Edition - January 14, 2004
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Free radical reactions have become increasingly important and a very attractive tool in organic synthesis in the last two decades, due to their powerful, selective, specific, and… Read more
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Free radical reactions have become increasingly important and a very attractive tool in organic synthesis in the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Advanced Free Radical Reactions for Organic Synthesis reviews information on all types of practical radical reactions, e.g. cyclizations, additions, hydrogen-atom abstractions, decarboxylation reactions. The book usefully provides experimental details for the most important reactions as well as numerous references to the original literature. By covering both the fundamentals and synthetic applications it is therefore suitable for both new and experienced researchers, chemists, biochemists, natural product chemists and graduate students. This title is the definitive guide to radical chemistry for all scientists.
Introduces and reviews the use of radicals to perform synthetic transformations
Practical details are provided for the most important methods
Numerous references to the original literature
New and experienced researchers, chemists, biochemists, natural product chemists and graduate students
1. What are Free Radicals? General Aspects of Free Radicals -Aspects of free radicals -Types of free radicals -Reaction style of radicals -Orientation in radical additions -Reactivity in radical additions -Reaction patterns of radicals -Generation of radicals Familiar and Close Radicals in Our Lives Stable Free Radicals Physical and Chemical Characteristics of Free Radicals -Orbital interactions between radicals and olefins -Baldwin's rule -Rate constants in radical reactions
2. Functional Group Conversion Radical Coupling Reactions Radical Reduction Conversion to Hydroxy Group and Other Functional Groups
3. Intramolecular Radical Cyclizations Cyclization to Small-Sized Rings -Cyclization onto olefinic group and acetylenic group by sp3 carbon-centered radicals -Cyclization onto Olefinic Group and Aromatic Group by sp2 Carbon-Centered Radicals -Generation of sp carbon-centered radicals. -Cyclization onto carbonyl group by sp3 or sp2 carbon-centered radicals and other related cyclizations Cyclization to Medium-Sized and Large-Sized Rings Ring Expansions Cyclization to Spiro Skeleton Tandem Cyclization to Polycyclic Rings
4. Intermolecular Radical Addition Reactions Addition to Olefins -Reductive conditions -Oxidative conditions -Photochemical conditions -Addition-elimination reactions Allylation Reactions Addition-Cyclization Reactions Reactions with Carbon Monoxide Addition to Acetylenes
6. Intramolecular Hydrogen-Atom Abstraction Hydrogen-atom Abstraction by Oxygen-Centered Radicals: Barton Reaction Hydrogen-atom Abstraction by Nitrogen-Centered Radicals: Hofmann-Löffler-Freytag Reaction Hydrogen-atom Abstraction by Carbon-Centered Radicals
7. Synthetic Uses of Free Radicals for Nucleosides and Sugars: Barton-McCombie Reaction
8. Barton Decarboxylation Reaction with N-hydroxy-2-thiopyridone Reduction Conversion to Halides Conversion to Chalcogenides Conversion to Other Functional Groups Carbon-Carbon Bond Formation -Intramolecular radical cyclization -Intermolecular coupling reaction -Intermolecular addition reaction -Alkylation of aromatics -Others
9. Free Radical Reactions with Metal Hydrides
10. Stereochemistry in Free Radical Reactions Reduction Carbon-Carbon Bond Formation
11. Free Radicals Related to Biology Vitamin B12 Ene-diyne Reactions: Bergman Cyclization Radical 1,2-Acyloxy Transfer
12. Free Radicals for Green Chemistry Design of Free Radical Precursors Application of Free Radicals to Environmentally Benign Synthesis