Advanced Biosensors for Virus Detection
Smart Diagnostics to Combat SARS-CoV-2
- 1st Edition - March 4, 2022
- Editors: Raju Khan, Arpana Parihar, Ajeet Kumar Kaushik, Ashok Kumar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 4 9 4 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 9 8 9 - 9
Advanced Biosensors for Virus Detection: Smart Diagnostics to Combat Against the SARS-CoV2 Pandemic covers the development of biosensor-based approaches for the diagnosis and progn… Read more
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Request a sales quoteAdvanced Biosensors for Virus Detection: Smart Diagnostics to Combat Against the SARS-CoV2 Pandemic covers the development of biosensor-based approaches for the diagnosis and prognosis of viral infections, specifically coronaviruses. The book discusses wide-ranging topics of available biosensor-based technologies and their application for early viral detection. Sections cover the emergence of SARS-CoV, MERS-CoV and SARS-CoV2, the global health response, the impact on affected populations, state-of-the art biomarkers, and risk factors. Specific focus is given to COVID-19, with coverage of genomic profiling, strain variation and the pathogenesis of SARS-CoV2.
In addition, current therapeutics, nano-abled advancements and challenges in the detection of SARS-CoV2 and COVID-19 management are discussed, along with the role of nanomaterials in the development of biosensors and how biosensors can be scaled up for clinical applications and commercialization.
- Deals with biosensors-based approaches that could be exploited to design and develop high throughput, rapid and cost-effective diagnostics technologies for the early detection of viral infections
- Illustrates the development of multiplexed, miniaturized analytical systems for point-of-care applications
- Provides information about fabrication protocols for various biosensor based diagnostic approaches that could be directly implemented to develop a novel biosensor
- Includes the past, present and future status of biosensors, along with information about biosensors currently under clinical trials
Virologists, clinicians, biomedical engineers, pathologists, molecular biologists, medical practitioners, analytical chemists and academics
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Acknowledgments
- Chapter 1. The emergence of severe acute respiratory syndrome-coronavirus 2 epidemic and pandemic
- Abstract
- 1.1 Introduction
- 1.2 Severe acute respiratory syndrome-coronavirus 2: the member of the coronavirus family
- 1.3 Virion structure of severe acute respiratory syndrome-coronavirus 2
- 1.4 Pathophysiology of severe acute respiratory syndrome-coronavirus 2 infection
- 1.5 Transmissibility of severe acute respiratory syndrome-coronavirus 2
- 1.6 Origin and etiology of severe acute respiratory syndrome-coronavirus 2
- 1.7 From epidemic to pandemic
- 1.8 Perspective
- References
- Chapter 2. Lesson learned from coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2) and socioeconomic impact of (SARS-CoV-2) pandemic
- Abstract
- 2.1 Introduction
- 2.2 Coronaviruses and family
- 2.3 Diagnostics
- 2.4 Therapeutics
- 2.5 Vaccines
- 2.6 World health response to coronavirus disease
- 2.7 Public health response to coronavirus disease
- 2.8 Human–animal nexus
- 2.9 What we learned from pandemic and future
- 2.10 Conclusion
- Acknowledgment
- Conflicts of interest
- References
- Chapter 3. Structure, genomic analysis, and pathogenesis of SARS-CoV-2
- Abstract
- 3.1 Classification of coronaviruses
- 3.2 Morphology and structure of SARS-CoV-2
- 3.3 Nonstructural proteins
- 3.4 Genomic analysis
- 3.5 Pathogenesis of coronavirus 19
- 3.6 Extrapulmonary manifestations of coronavirus 19
- 3.7 Conclusion
- Acknowledgment
- References
- Chapter 4. COVID-19 diagnosis: approaches and challenges
- Abstract
- 4.1 Introduction
- 4.2 Sample collection
- 4.3 qRT-PCR for detection of SARS-CoV-2 RNA
- 4.4 Cartridge-based nucleic acid amplification tests
- 4.5 Pooling of specimens for nucleic acid amplification test
- 4.6 Isothermal assays
- 4.7 Rapid antigen detection test
- 4.8 Quality control of COVID-19 testing
- 4.9 Conclusion
- References
- Chapter 5. Current therapeutic choices for coronavirus disease 2019: a state-of-the-art review
- Abstract
- 5.1 Introduction
- 5.2 Pathophysiology of coronavirus disease
- 5.3 Therapeutics of proven utility, targeting stage of infection and viremia
- 5.4 Therapeutics of limited or unproven utility, targeting stage of Infection and viremia
- 5.5 Therapeutics of proven utility, targeting cytokine storm
- 5.6 Therapeutics of limited utility, targeting cytokine storm
- 5.7 Therapeutics of limited or uncertain utility, targeting post-coronavirus disease complications
- 5.8 Conclusion
- References
- Chapter 6. Genomic, proteomic biomarkers and risk factors associated with COVID-19
- Abstract
- 6.1 Introduction
- 6.2 Biomarkers
- 6.3 Proteomic Biomarkers for COVID-19
- 6.4 Genetic biomarkers
- 6.5 Conclusion and future perspective
- References
- Chapter 7. Biological/synthetic receptors (antibody, enzyme, and aptamer) used for biosensors development for virus detection
- Abstract
- 7.1 Introduction
- 7.2 Types of bioreceptors
- 7.3 Properties of biosensors based on bioreceptors
- 7.4 Examples of biosensors for detection of coronavirus disease 2019 based on different bioreceptors
- 7.5 Future prospects
- 7.6 Conclusion
- References
- Chapter 8. Potential electrochemical biosensors for early detection of viral infection
- Abstract
- 8.1 Introduction
- 8.2 Types of viral infections and their detection
- 8.3 Conclusion
- References
- Chapter 9. Optical biosensors for SARS-CoV-2 detection
- Abstract
- 9.1 Introduction
- 9.2 Biosensors: an introduction to optical biosensors
- 9.3 Surface-plasmon resonance-based biosensors
- 9.4 Localized surface plasmon resonance-based optical biosensors
- 9.5 Surface-enhanced Raman scattering-based optical biosensors
- 9.6 Optical lateral flow assay for SARS-CoV-2-detection
- 9.7 Challenges in developing optical biosensors
- 9.8 Conclusion and future perspectives
- Acknowledgments
- References
- Chapter 10. Recent developments of molecular/biosensor diagnostics for SARS-CoV-2 detection
- Abstract
- 10.1 Introduction
- 10.2 Nucleic acid-based detection
- 10.3 Serological testing
- 10.4 Biosensors for COVID-19 diagnostics
- 10.5 Electrical and piezoelectric biosensors
- 10.6 Future directions
- 10.7 Conclusions
- Acknowledgments
- References
- Chapter 11. Role of magnetic nanoparticles in development of biosensors for viral infection diagnostics
- Abstract
- 11.1 Introduction
- 11.2 Capture, preconcentration, extraction
- 11.3 Multiple detections with immunomagnetic separation
- 11.4 Labeling
- 11.5 Magnetic label
- 11.6 Fluorometric label
- 11.7 Labeling based on the enzyme-like activity of magnetic nanoparticles
- 11.8 Dual role of magnetic nanoparticles and application in microfluidics
- 11.9 Conclusion and perspective
- References
- Chapter 12. Advances in nanomaterials-based biosensors for the development of virus detection
- Abstract
- 12.1 Introduction
- 12.2 Fundamental principles
- 12.3 Gold nanoparticles-based biosensor
- 12.4 Quantum dots-based nanomaterials
- 12.5 Upconversion nanoparticles
- 12.6 Conclusion and future perspective
- Abbreviations
- References
- Chapter 13. Multiplexed biosensors for virus detection
- Abstract
- 13.1 Introduction
- 13.2 Biosensors
- 13.3 Application of multiplex biosensors on detection of viruses
- 13.4 Conclusion
- 13.5 Future perspectives
- References
- Chapter 14. Electrical biosensors for virus detection
- Abstract
- 14.1 Introduction
- 14.2 Electrical biosensor
- 14.3 Electrode-based biosensor
- 14.4 Transistor-based biosensor
- 14.5 Biorecognition elements
- 14.6 Electrical biosensor measurement techniques
- 14.7 Recent development in electrical biosensor
- 14.8 Conclusion and future scope
- Abbreviations
- References
- Chapter 15. Diagnostic biosensors for coronaviruses and recent developments
- Abstract
- 15.1 Introduction
- 15.2 Traditional detection methods
- 15.3 Biosensors in coronavirus detection
- 15.4 Conclusions and future perspectives
- References
- Chapter 16. Fluorescence-based biosensors for SARS-CoV-2 viral infection diagnostics
- Abstract
- 16.1 Introduction
- 16.2 Fluorescence-based strategies in biosensors
- 16.3 Fluorescence-based biosensors in viral diagnostic applications
- 16.4 Advances in fluorescence-based biosensors for SARS-CoV-2 viral infection diagnostics
- 16.5 Conclusion
- References
- Chapter 17. Miniaturized analytical system for point-of-care coronavirus infection diagnostics
- Abstract
- 17.1 Introduction
- 17.2 Current diagnostic techniques
- 17.3 Potential point-of-car miniaturized biosensor
- 17.4 Conclusion
- Acknowledgments
- References
- Chapter 18. Microfluidic devices with integrated biosensors for coronavirus infection diagnostics
- Abstract
- 18.1 Introduction to coronavirus
- 18.2 Available detection methods for SARS-CoV-2 virus
- 18.3 Microfluidic-based biosensor system
- 18.4 Commercially available biosensor systems
- 18.5 Conclusion
- Acknowledgment
- Conflicts of interest
- References
- Chapter 19. Approaches for fabrication of point-of-care biosensors for viral infection
- Abstract
- 19.1 Introduction
- 19.2 Methodology for fabrication of biosensor
- 19.3 Fabrication of electrochemical biosensor
- 19.4 Fabrication of optical biosensor
- 19.5 Fabrication of paper-based biosensor
- 19.6 Fabrication of microfluidic and lab-on-a-chip biosensor
- 19.7 Fabrication of molecularly imprinted polymer-based biosensor
- 19.8 Fabrication of magnetic biosensor
- 19.9 Fabrication of three-dimensional printing biosensor
- 19.10 Conclusion
- Acknowledgments
- References
- Chapter 20. Currently available biosensor-based approaches for severe acute respiratory syndrome-coronavirus 2 detection
- Abstract
- 20.1 Introduction
- 20.2 Diagnostic approaches for viral diseases
- 20.3 Biosensors in the detection of respiratory viruses
- 20.4 Present diagnostic methods for severe acute respiratory syndrome-coronavirus 2 detection
- 20.5 Advantages offered by biosensors
- 20.6 Concluding remark
- Abbreviations
- References
- Chapter 21. Biosensors-based approaches for other viral infection detection
- Abstract
- 21.1 Introduction
- 21.2 Appropriate target sites for the detection of viruses
- 21.3 Importance of biosensor in the diagnostics
- 21.4 Detection of mammalian viruses by a biosensor
- 21.5 Importance and significance of biological analytes
- 21.6 Future scopes
- Abbreviations
- References
- Further reading
- Chapter 22. Scaling up of biosensors for clinical applications and commercialization
- Abstract
- 22.1 Introduction
- 22.2 Commercialization of biosensors
- 22.3 Future outlook
- References
- Chapter 23. Future aspects of biosensor-based devices in disease detection
- Abstract
- 23.1 Introduction
- 23.2 Need for advanced nanobiosensors
- 23.3 Detection of metabolites and metals by nanobiosensors
- 23.4 Applications of nanobiosensors in the detection of noncommunicable diseases
- 23.5 Applications of nanobiosensors in the detection of infectious diseases
- 23.6 Advanced biosensing applications toward disease detection
- 23.7 Conclusion
- Acknowledgment
- References
- Further reading
- Index
- No. of pages: 476
- Language: English
- Edition: 1
- Published: March 4, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780128244944
- eBook ISBN: 9780323859899
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Raju Khan
Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.
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Arpana Parihar
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Ajeet Kumar Kaushik
Dr. Ajeet Kaushik is Associate Professor at the NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, USA. He is the recipient of various reputed awards for his service in the area of nano-biotechnology for health care. He has edited seven books, written more than 100 international research peer reviewed publications, and has three patents in the area of nanomedicine and smart biosensors for personalized health care. In the course of his research, Dr. Kaushik has been engaged in the design and development of various electro-active nanostructures for electrochemical biosensor and nanomedicine for health care. His research interests include nanobiotechnology, analytical systems, design and develop nanostructures, nano-carries for drug delivery, nano-therapeutics for CNS diseases, on-demand site-specific release of therapeutic agents, exploring personalized nanomedicines, biosensors, point-of-care sensing devices, and related areas of health care monitoring.
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