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Adenosine A2A Receptor Antagonists

1st Edition - September 19, 2023

Editors: Jiang-Fan Chen, Akihisa Mori

Hardback ISBN:

9 7 8 - 0 - 4 4 3 - 1 8 6 6 7 - 7

eBook ISBN:

9 7 8 - 0 - 4 4 3 - 1 8 6 6 8 - 4

Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting… Read more

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Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry – agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors – biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson’s disease therapy, and much more.

Cover image
Title page
Table of Contents
Series Page
Copyright
Contributors
Preface
Chapter One: A2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists
Abstract
1 Introduction
2 A2AAR agonists
3 Positive allosteric enhancers (PAMs)
4 A2AAR antagonists and inverse agonists
5 Negative allosteric enhancers (NAMs)
6 A2AAR partial agonists
7 Conclusions
References
Chapter Two: Adenosine A2A receptor and glia
Abstract
1 Preface
2 A2AR in astrocytes
3 Astrocyte A2AR and Alzheimer’s disease
4 Astrocyte A2AR and PD
5 A2AR and microglia
6 Microglial A2A receptor and process retraction
7 Microglial A2A receptor and neuroinflammation
8 Microglial A2AR and AD
9 Microglial adenosine A2AR and PD
10 Microglial adenosine A2A receptor and stroke
11 Microglial A2AR in other diseases
12 Role of other microglial adenosine A1 and A3 receptors
13 A2AR and oligodendrocytes
14 Perspective
References
Chapter Three: The adenosine A2A receptor in the basal ganglia: Expression, heteromerization, functional selectivity and signalling
Abstract
Abbreviations
1 Introduction
2 Expression of A2AR in the basal ganglia
3 Functional selectivity and signalling of A2AR
4 Heteromer expression in neurological diseases affecting the basal ganglia and in alterations of the reward circuits by drugs of abuse
5 Concluding remarks
Conflict of interests
References
Chapter Four: How and why the adenosine A2A receptor became a target for Parkinson’s disease therapy
Abstract
1 Introduction
2 The relevance of the adenosinergic system and the A2A adenosine receptor
3 Adenosine A2A receptors and motor function
4 Adenosine A2A antagonists and dyskinesia
5 Adenosine A2A antagonists and motor function in Parkinson’s disease
6 Other potential mechanisms of action of A2A adenosine antagonists
7 Adenosine antagonists and non-motor symptoms of Parkinson’s disease
8 Exploring the future potential of adenosine A2A antagonists in Parkinson’s disease
References
Chapter Five: Adenosine A2A antagonists and Parkinson’s disease
Abstract
1 Introduction
2 Receptor agonists
3 Inverse agonists
4 Receptor antagonists
References
Chapter Six: Effects of adenosine A2A receptors on cognitive function in health and disease
Abstract
1 Introduction
2 Effects of A2A receptor modulation on normal cognitive function
3 Effects of A2A receptor modulation on cognitive impairments in aging and disease
4 Effects of A2A receptor modulation on cognitive impairments in stress
5 Effects of A2A receptor modulation on drug use and addiction
6 Conclusions
References
Chapter Seven: Adenosine A2A receptors and sleep
Abstract
1 Introduction
2 Adenosine and its receptors
3 The role of adenosine and A2ARs in sleep-wake regulation
4 Conclusion
References
Chapter Eight: Adenosine A2A signals and dystonia
Abstract
Body
References
Chapter Nine: A2AR antagonist treatment for multiple sclerosis: Current progress and future prospects
Abstract
Abbreviation
1 Introduction
2 Adenosine metabolism
3 A2AR distribution in MS/EAE pathology
4 The confusing effect of A2AR signaling in MS/EAE
5 A2AR signaling in macrophages and dendritic cells
6 The complex effects of A2AR signaling in T cells
7 A2AR signaling is essential for maintaining the suppressive capacity of Tregs
8 A2AR antagonist attenuates the pro-inflammation phenotype of microglia
9 A2AR antagonist inhibits the activation of astrocytes
10 The A2AR antagonist protects oligodendrocytes from damage
11 A2AR antagonist protects against lymphocyte infiltration into the CNS across the BBB
12 A2AR antagonist suppresses T-cell infiltration by decreasing the ChP gateway activity
13 Safety of the A2AR antagonist in clinical trials
14 The limitations of current studies on the potential efficacy of A2AR antagonists in MS pathology
15 Conclusion
References
Chapter Ten: A2AR and traumatic brain injury
Abstract
1 Preface
2 A2AR modulation of neuroinflammation at the early stage of TBI
3 A2AR modulation of glutamate excitotoxicity at the early stage of TBI
4 A2AR modulation of aberrant proteins
5 A2AR modulation of cognitive dysfunction after TBI
6 A2AR modulation of chronic neuroinflammation in TBI
7 A2AR modulation of other long-lasting consequences of TBI
References
Chapter Eleven: Chemobrain: An accelerated aging process linking adenosine A2A receptor signaling in cancer survivors
Abstract
1 Introduction
2 Adenosine A2AR in cognitive function
3 Findings of cognitive dysfunction in chemobrain
4 Chemobrain as an accelerated aging phenotype in adult and pediatric cancer
5 The adenosine A2A receptor as a potential mechanism of accelerated aging in chemobrain and cancer
6 Concluding remarks
References