Actin Cytoskeleton in Cancer Progression and Metastasis – Part C
- 1st Edition, Volume 360 - May 4, 2021
- Editors: Fernando Aranda Vega, Lorenzo Galluzzi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 1 3 8 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 1 3 9 - 4
Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles… Read more
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Request a sales quoteActin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more.
- Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology
- Offers a wide range of perspectives for basic and translational research
- Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Advanced undergraduates, graduates, academics and researchers in the area of cancer biology
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Force balancing ACT-IN the tumor microenvironment: Cytoskeletal modifications in cancer and stromal cells to promote malignancy
- Abstract
- 1: Overview
- 2: Actin cytoskeleton
- 3: Measuring intracellular and extracellular forces
- 4: Utilizing force measurements to distinguish non-invasive and invasive cancer cells
- 5: Utilizing force measurements to study tumor and stromal cell crosstalk
- 6: Conclusions
- 7: Experimental challenges and future research efforts
- Chapter Two: Novel facets of glioma invasion
- Abstract
- 1: Introduction
- 2: Routes of glioma cell invasion
- 3: Modes of glioma cell invasion
- 4: The impact of tumor metabolism on cell invasion
- 5: The extracellular matrix of the glioma microenvironment
- 6: Involvement of proteases and the tumor microenvironment in glioma cell invasion
- 7: The actin cytoskeleton and its related membrane protrusions in glioma cell invasion
- 8: Can glioma cell invasion and the actin cytoskeleton be targeted?
- 9: Conclusions and future prospects
- Acknowledgments
- Chapter Three: Actin dynamics during tumor cell dissemination
- Abstract
- 1: Introduction
- 2: Tumor dissemination and metastasis
- 3: Cancer cell migration
- 4: Actin structures in cancer cell migration
- 5: The cell cycle and cancer cell invasion
- 6: Imaging advances and future directions in studying tumor cell invasion
- 7: Conclusion
- Acknowledgments
- Chapter Four: The multiple roles of actin-binding proteins at invadopodia
- Abstract
- 1: Introduction
- 2: Invadopodial actin assemblies
- 3: Actin machineries at the cell leading edge
- 4: Actin-binding proteins in invadopodia morphogenesis
- 5: Actin polymerization-based protrusion at invadopodia
- 6: Concluding remarks
- Acknowledgments
- Chapter Five: Cancer type-specific alterations in actin genes: Worth a closer look?
- Abstract
- 1: Introduction
- 2: The human actin gene/protein family: A tale of functional redundancy and distinction
- 3: Actin: Basic structure-function relationships as a context for interpreting actin mutations in cancer
- 4: Actin gene alterations and actin mutants: Do they occur in cancer?
- 5: Alterations in actin genes in patient cancer genomes: An untapped resource
- 6: Summary, conclusions, and perspectives
- No. of pages: 192
- Language: English
- Edition: 1
- Volume: 360
- Published: May 4, 2021
- Imprint: Academic Press
- Hardback ISBN: 9780128241387
- eBook ISBN: 9780128241394
FA
Fernando Aranda Vega
Fernando Aranda holds a BSc in Biology (2006) and Biochemistry (2007) from the University of Navarra. Then, he specialized in different strategies of Cancer Immunotherapy with a MSc in Biomedical Research (2008), and a PhD Degree (2012) from the University of Navarra (Pamplona) – Cima University of Navarra. More than 12 years in translational research focus on antitumor immune responses and Cancer Immunotherapy. Author of 64 publications indexed in PubMed in prestigious international journals, with h-index 30 and 4,296 cites (October 2022). He completed the Program of Sara Borrell (ISCIII) -competitive Postdoctoral contract- in the Group of Immune Receptors of the Innate and Adaptive System (IDIBAPS), Barcelona (2016-2018). Co-author of 1 invention patent: Composition based on the fibronectin domain A for the treatment of melanoma - WO/2011/101332. In 2012, Fernando Aranda obtained a Scientific Award, "Profesor Durantez" II Edición, for the best scientific article in Tumor Immunology by Fundación LAIR. Recently, Fernando Aranda awarded a competitive Research Fellow contract “Miguel Servet tipo I” by Instituto de Salud Carlos III, to continue his independent researcher career (IP) in cancer immunotherapy issues. Specifically, he is involved in Translational Immunotherapy of Peritoneal Carcinomatosis. Currently, Fernando Aranda leads a research group in cooperation with Dr. Pedro Berraondo.
Affiliations and expertise
Fernando Aranda Vega, CIMA Universidad de Navarra, Program of Immunology and Immunotherapy, SpainLG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USARead Actin Cytoskeleton in Cancer Progression and Metastasis – Part C on ScienceDirect