Actin Cytoskeleton in Cancer Progression and Metastasis - Part B
- 1st Edition, Volume 356 - October 12, 2020
- Imprint: Academic Press
- Editors: Lorenzo Galluzzi, Fernando Aranda Vega
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 8 3 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 8 4 - 4
Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the ro… Read more
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Request a sales quoteActin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more.
- Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology
- Offers a wide range of perspectives for basic and translational research
- Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Advanced undergraduates, graduates, academics and researchers in the area of cancer biology
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Two sides of the coin: Cytoskeletal regulation of immune synapses in cancer and primary immune deficiencies
- Abstract
- 1: Immune cells on the move—Requirement for actin cytoskeleton dynamics
- 2: Actin in cell-cell contacts: Immunological synapses
- 3: Primary immunodeficiency diseases reveal the critical role of actin regulators in immune cells
- 4: Actin in cell transformation
- 5: Clinical relevance and therapy
- Acknowledgments
- Chapter Two: Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes
- Abstract
- 1: Introduction
- 2: Actin cytoskeleton remodeling in mounting tumor resistance to cytotoxic lymphocytes
- 3: Neutralizing lymphocyte-mediated cytotoxicity by vesicular trafficking
- 4: Tumor cell-secreted exosomes impair immune synapse functions
- 5: Clinical potential of targeting tumor synaptic defense mechanisms and conclusion
- Acknowledgments
- Chapter Three: Actin regulators in cancer progression and metastases: From structure and function to cytoskeletal dynamics
- Abstract
- 1: Introduction
- 2: Nucleating factors (NFs) and their dysfunction in cancer
- 3: Dysfunction of nucleation-promoting factors (NPFs) in cancer
- 4: Prospective: Targeting the actin cytoskeleton as a therapeutic approach
- 5: Concluding remarks
- Chapter Four: Actin cytoskeleton in mesenchymal-to-amoeboid transition of cancer cells
- Abstract
- 1: Introduction
- 2: Modes of tumor cells migration
- 3: Small GTPases as main regulators of migration
- 4: Migration plasticity of cancer cells
- 5: Regulation of migration plasticity
- 6: Conclusions and open questions
- Acknowledgments
- Chapter Five: The microenvironment and cytoskeletal remodeling in tumor cell invasion
- Abstract
- 1: Introduction
- 2: ECM stiffness
- 3: ECM topography
- 4: Mimicking the physical parameters of ECM
- 5: Conclusion
- Chapter Six: Myosins: Driving us towards novel targets and biomarkers in cancer
- Abstract
- 1: The myosin super-family
- 2: The role of myosins in health and diseases
- 3: Myosins in cancer
- 4: Conclusion
- Funding
- Edition: 1
- Volume: 356
- Published: October 12, 2020
- No. of pages (Hardback): 330
- No. of pages (eBook): 330
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128212837
- eBook ISBN: 9780128212844
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USAFA
Fernando Aranda Vega
Fernando Aranda holds a BSc in Biology (2006) and Biochemistry (2007) from the University of Navarra. Then, he specialized in different strategies of Cancer Immunotherapy with a MSc in Biomedical Research (2008), and a PhD Degree (2012) from the University of Navarra (Pamplona) – Cima University of Navarra. More than 12 years in translational research focus on antitumor immune responses and Cancer Immunotherapy. Author of 64 publications indexed in PubMed in prestigious international journals, with h-index 30 and 4,296 cites (October 2022). He completed the Program of Sara Borrell (ISCIII) -competitive Postdoctoral contract- in the Group of Immune Receptors of the Innate and Adaptive System (IDIBAPS), Barcelona (2016-2018). Co-author of 1 invention patent: Composition based on the fibronectin domain A for the treatment of melanoma - WO/2011/101332. In 2012, Fernando Aranda obtained a Scientific Award, "Profesor Durantez" II Edición, for the best scientific article in Tumor Immunology by Fundación LAIR. Recently, Fernando Aranda awarded a competitive Research Fellow contract “Miguel Servet tipo I” by Instituto de Salud Carlos III, to continue his independent researcher career (IP) in cancer immunotherapy issues. Specifically, he is involved in Translational Immunotherapy of Peritoneal Carcinomatosis. Currently, Fernando Aranda leads a research group in cooperation with Dr. Pedro Berraondo.
Affiliations and expertise
Fernando Aranda Vega, CIMA Universidad de Navarra, Program of Immunology and Immunotherapy, SpainRead Actin Cytoskeleton in Cancer Progression and Metastasis - Part B on ScienceDirect