A Review on Diverse Neurological Disorders

Pathophysiology, Molecular Mechanisms, and Therapeutics

1st Edition - June 1, 2024

Editors: Abhai Kumar, Rameshwar Nath Chaurasia, Sunny Ohia, Debasis Bagchi

Paperback ISBN:

9 7 8 - 0 - 3 2 3 - 9 5 7 3 5 - 9

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 5 7 3 6 - 6

According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease,… Read more

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According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease, strokes, and headaches. Neurological disorders also include brain injuries, neuroinfections, multiple sclerosis and Parkinson disease. A Review on Diverse Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics covers the major topics related to neurological disorders, current challenges in diagnosis and intervention. This book is organized into four distinct sections, starting with an introduction, providing a general overview of the epidemiology of neurological disorders, pathogenesis and management. The second section presents the aspects of brain diseases due to infection of bacteria, parasite, fungus and viruses. The third section discusses neurodegenerative disorders due to comorbid factors like diabetes, hypertension, hyperlipidemia and post traumatic brain injuries. The last section covers prevention through application of bioactive compounds and neuroprotective agents.

1. Neurological Disorders: Epidemiology, Pathophysiology and Burden of Disease

2. Diverse Neurological Diseases: Bacterial, Fungal, Virus and Parasitic Infections

3. Tuberculosis of Central Nervous System

4. Tetanus, Diphtheria and other bacterial infection of Central Nervous System

5. Pathogenesis and Treatment of Syphilis

6. Fungal infection of Central Nervous System

7. Acute Viral Encephalitis, Bacterial Meningitis and Cerebral Malaria

8. Herpes Virus Infections of the Nervous System

9. Neurological complications of COVID-19 infections

10. Pathogenesis and treatment of RABIES

11. Helminth infection of Central Nervous System

12. Neuroinflammation, Hippo Signaling Pathogenesis in Zika Virus Replication

13. Neurodegeneration in Autoimmune Central Nervous System Infection

14. HIV Infection, Type 1 Interferons, and Immune Competence: Correlating Brain Immunity to Neurodegeneration

15. Diverse Neurodegenerative Disorders

16. Alzheimer’s and Parkinson’s Disease: An Overview

17. Ataxia and Motor Neuron Diseases

18. An Overview on Huntington’s Disease

19. Multiple System Atrophy

20. Progressive Supranuclear Palsy

21. Inflammation and Neurodegeneration in Multiple Sclerosis

22. Autophagy and Mitophagy in Amyotrophic Lateral Sclerosis (ALS)

23. Epilepsy and Neurodegeneration

24. Stroke, Cerebrovascular Injury and Neurodegeneration

25. Synaptic Plasticity, TNFa and IL-1b: Neurological and Psychiatric Disorders

26. Application of optical coherence tomography in multiple sclerosis

27. Influence of Axonal Pathology in Traumatic Brain Injury

28. Diabetic Retinopathy, Glaucoma and Diverse Ocular Neurodegenerative Disorders

29. Molecular Mechanisms in Neurodegeneration

30. Neuroinflammation: Role of Adhesion Molecules and Signaling Networks in Neurovascular Systems

31. Neurodegeneration and Motor Deficits

32. Stress in Neurodegeneration

33. Diverse Stress and Neurodegeneration: An Overview

34. Stress Granule Dynamics in Neurodegeneration

35. Advancing Age and Neurodegeneration

36. Brain Ageing and Neurodegenerative Diseases

37. Environmental Neurotoxicants, microRNAs, and Advancing Age in Neurodegeneration

38. Advancing Age, Insomnia, Nutraceuticals, and Neuroprotection

39. Neuroprotection and Bioactive compounds

40. Novel Therapeutics for Diverse Neurological Disorders

41. Vitamins, Micronutrients, Antioxidants, and Nutraceuticals in Neuroprotection: An Overview
Commentary

Abhai Kumar

Abhai Kumar, Ph.D., received his PhD degree in Biotechnology in 2008 from CSIR –Indian Institute of Toxicology Research, Lucknow, India. Dr. Abhai is currently working as Principal Research Scientist at Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Dr. Abhai served as Postdoctoral Fellow at University of Pittsburgh, Pittsburgh, USA from 2008 to 2010. Dr. Abhai identified several novel drug targets during his work at University of Pittsburgh, USA. He worked at India most prestigious institute National Institute of Immunology, New Delhi on glycoproteomics for drug targets of cancer. Dr. Abhai has published more than 35 research articles in journal of high repute and wrote more than 15 book chapter in various prestigious international books, Dr. Abhai has edited two books on neurodegeneration and diseases of elderly population published from Taylor and Francis and Nova Science, USA respectively. He is reviewer of several journals and member of editorial board of International journals. He is also working as ex-officio member of ‘Chand Foundation’ a voluntary organization dealing with mental health of elderly people in India. Dr. Abhai research interests include neurodegenerative disorders, free radicals, human diseases, anti-ageing and anti-inflammatory pathophysiology, and cognition.

Affiliations and expertise

Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Rameshwar Nath Chaurasia

Rameshwar Nath Chaurasia MBBS, MD, DM, MAMS received his D.M. in Neurology in 2009 from King George Medical University, Lucknow, India. He did his MBBS and M.D.(Medicine) from Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. At present he is Professor & Head in the Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi. He served in the University at various administrative posts like Student Advisor, Anti Ragging Committee of University team, Deputy Chief Proctor etc.,He also served as founder Nodal officer of Ayushman Bharat Yojana (Biggest Health Scheme Yojana in World) in Sir Sundar Lal Hospital, I.M.S. BHU. He is Executive Council Member of AIIMS, Gorakhpur, Uttar Pradesh, India. Dr. Chaurasia received various awards/prizes from different Scientific/Non-scientific organizations and Societies for creating awareness about various neurological diseases in societies. His passion is to serve the needy people of India living in remote areas of different states of India by arranging health camps with the help of National Medicos Organization and Sewa Bharati of India. He also got teacher awards on teacher’s day from Governor and Chief Minister of Uttar Pradesh, India in 2017 and 2021 respectively. Dr R N Chaurasia has contributed >90 research papers in various peer reviewed national and international journals. He also contributed >10 book chapters in various books. He is reviewer of many national and international peer reviewed journals (>6). His main area of research is in the field of stroke, Epilepsy, cognitive science and CNS infections. He is member of various academic bodies in the field of neurosciences like Indian Academy of Neurology, Neurological Society of India, International Parkinson and Movement Disorder Society & American Academy of Neurology etc.

Affiliations and expertise

Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Sunny Ohia

Sunny Ohia, Ph.D., FARVO, FAS is a Professor of Pharmacology in the College of Pharmacy and Health Sciences at Texas Southern University. Dr. Ohia has over 28 years of experience in higher education having served as a member of faculty in five universities in Canada and the United States (U.S.). He holds other academic appointments as adjunct professor of ophthalmology and visual sciences at the University of Nebraska Medical Center, Omaha and as an adjunct professor of integrative biology and pharmacology at the University of Texas Health Sciences Center in Houston. Dr. Ohia is a Fellow of the Nigerian Academy of Science and a Fellow of the Association for Research in Vision and Ophthalmology. He is the author of more than 250 original papers, book chapters, books, and abstracts and, holds three U.S. and five international Patents for his scientific work. Dr. Ohia received his Ph.D. in pharmacology from the University of Glasgow, in Scotland, United Kingdom. Dr. Ohia completed postdoctoral research training fellowships in neuroscience and in ophthalmology/visual sciences at Memorial University of Newfoundland, Canada and the University of Louisville, School of Medicine, KY, respectively.

Affiliations and expertise

Professor, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA

Debasis Bagchi

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Affiliations and expertise

Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USA